Role of angiomotin family members in human diseases (Review)
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- Published online on: April 23, 2024 https://doi.org/10.3892/etm.2024.12546
- Article Number: 258
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Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
Angiomotin (Amot) family members, including Amot, Amot‑like protein 1 (Amotl1) and Amot‑like protein 2 (Amotl2), have been found to interact with angiostatins. In addition, Amot family members are involved in various physiological and pathological functions such as embryonic development, angiogenesis and tumorigenesis. Some studies have also demonstrated its regulation in signaling pathways such as the Hippo signaling pathway, AMPK signaling pathway and mTOR signaling pathways. Amot family members play an important role in neural stem cell differentiation, dendritic formation and synaptic maturation. In addition, an increasing number of studies have focused on their function in promoting and/or suppressing cancer, but the underlying mechanisms remain to be elucidated. The present review integrated relevant studies on upstream regulation and downstream signals of Amot family members, as well as the latest progress in physiological and pathological functions and clinical applications, hoping to offer important ideas for further research.
