Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors

  • Authors:
    • Dong‑Shu Zheng
    • Liang‑Shu Chen
  • View Affiliations

  • Published online on: August 3, 2017     https://doi.org/10.3892/etm.2017.4883
  • Pages: 3273-3278
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Abstract

Nasopharyngeal carcinoma (NPC) is a malignant disease that threatens the health of humans. To find effective agents for the inhibition of Epstein‑Barr virus (EBV) infection, which is associated with NPC, a phytochemical investigation of Ganoderma lucidum was carried out in the present study. Five triterpenoids were identified, including ganoderic acid A (compound 1), ganoderic acid B (compound 2), ganoderol B (compound 3), ganodermanontriol (compound 4), and ganodermanondiol (compound 5), on the basis of spectroscopic analysis. An inhibition of EBV antigens activation assay was implemented to elucidate the triterpenoids from G. lucidum and potentially prevent NPC. All the triterpenoids showed significant inhibitory effects on both EBV EA and CA activation at 16 nmol. At 3.2 nmol, all the compounds moderately inhibited the activation of the two antigens. The activity of telomerase was inhibited by these triterpenoids at 10 µM. Molecular docking demonstrated that compound 1 was able to inhibit telomerase as a ligand. In addition, the physicochemical properties of these compounds were calculated to elucidate their drug‑like properties. These results provided evidence for the application of these triterpenoids and whole G. lucidum in the treatment of NPC.

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October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zheng DS and Zheng DS: Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Exp Ther Med 14: 3273-3278, 2017
APA
Zheng, D., & Zheng, D. (2017). Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Experimental and Therapeutic Medicine, 14, 3273-3278. https://doi.org/10.3892/etm.2017.4883
MLA
Zheng, D., Chen, L."Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors". Experimental and Therapeutic Medicine 14.4 (2017): 3273-3278.
Chicago
Zheng, D., Chen, L."Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3273-3278. https://doi.org/10.3892/etm.2017.4883