Involvement of neurokinin 1 receptor within the cerebrospinal fluid‑contacting nucleus in visceral pain

  • Authors:
    • Chao Zhang
    • Ying Li
    • Xin Wang
    • Yan Fei
    • Licai Zhang
  • View Affiliations

  • Published online on: April 21, 2017     https://doi.org/10.3892/mmr.2017.6499
  • Pages: 4300-4304
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Abstract

Studies have shown that the cerebrospinal fluid‑contacting nucleus (CSF‑CN) may be associated with the transduction and regulation of pain signals. However, the role of the CSF‑CN remains to be elucidated. Emerging evidence has suggested that neurokinin 1 receptor (NK1R) is important in the development of visceral pain and hyperalgesia, however, whether NK1R exists in the CSF‑CN and its exact role in visceral pain remain to be fully elucidated. In the present study, double‑labeled immunofluorescence staining and western blot analysis were performed to investigate this. It was revealed that NK1R was distributed in the CSF‑CN. Following the induction of visceral pain by formalin instillation, NK1R in the CSF‑CN was upregulated. In addition, by observing the behaviors of rats subjected to visceral pain, it was found that visceral pain was relieved by lateral intracerbroventricular injection of the NK1R antagonist, RP67580. These data provided a broader understanding of the role of NK1R in the CSF‑CN and demonstrated that the CSF‑CN was involved in acute visceral pain via the regulation of NK1R.
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June-2017
Volume 15 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang C, Li Y, Wang X, Fei Y and Zhang L: Involvement of neurokinin 1 receptor within the cerebrospinal fluid‑contacting nucleus in visceral pain. Mol Med Rep 15: 4300-4304, 2017
APA
Zhang, C., Li, Y., Wang, X., Fei, Y., & Zhang, L. (2017). Involvement of neurokinin 1 receptor within the cerebrospinal fluid‑contacting nucleus in visceral pain. Molecular Medicine Reports, 15, 4300-4304. https://doi.org/10.3892/mmr.2017.6499
MLA
Zhang, C., Li, Y., Wang, X., Fei, Y., Zhang, L."Involvement of neurokinin 1 receptor within the cerebrospinal fluid‑contacting nucleus in visceral pain". Molecular Medicine Reports 15.6 (2017): 4300-4304.
Chicago
Zhang, C., Li, Y., Wang, X., Fei, Y., Zhang, L."Involvement of neurokinin 1 receptor within the cerebrospinal fluid‑contacting nucleus in visceral pain". Molecular Medicine Reports 15, no. 6 (2017): 4300-4304. https://doi.org/10.3892/mmr.2017.6499