Open Access

Diverse gene expression patterns in response to anticancer drugs between human and mouse cell lines revealed by a comparative transcriptomic analysis

  • Authors:
    • Yong Guo
    • Zhuoran Liang
    • Xiaoliang Hou
    • Zhi Zhang
  • View Affiliations

  • Published online on: August 4, 2017     https://doi.org/10.3892/mmr.2017.7176
  • Pages: 4469-4474
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to perform comparative genomics using gene expression profile datasets of mice and humans who had been treated with anticancer drugs, to determine the similarities and differences in the antitumor mechanisms in the two mammals. This involved data mining of antitumor gene expression regulation, and screening of genetic loci from experimental mouse models of antitumor targets, to provide a theoretical basis of drug design. Subsequently, 9 overlapping genes with opposite expression patterns were identified across mouse and human cell lines that were treated with a specific cyclin‑dependent kinase 4/6 inhibitor, PD0332991. These genes included LIM homeobox 2, adenomedullin, bone marrow stromal cell antigen 1, caveolin 1, histone cluster 1 (HIST1) H2B family member C, HIST1 H3 family member F, low density lipoprotein‑receptor related protein 11, prolyl 4‑hydroxylase subunit α1 and torsin family 3 member A. In addition, the janus kinase‑signal transducer and activator of transcription signaling pathway, Toll‑like receptor signaling pathway, T cell receptor signaling pathway and the nucleotide‑binding oligomerization domain‑like receptor signaling pathway were identified as candidate pathways for explaining antitumor mechanisms.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Guo Y, Liang Z, Hou X and Zhang Z: Diverse gene expression patterns in response to anticancer drugs between human and mouse cell lines revealed by a comparative transcriptomic analysis. Mol Med Rep 16: 4469-4474, 2017
APA
Guo, Y., Liang, Z., Hou, X., & Zhang, Z. (2017). Diverse gene expression patterns in response to anticancer drugs between human and mouse cell lines revealed by a comparative transcriptomic analysis. Molecular Medicine Reports, 16, 4469-4474. https://doi.org/10.3892/mmr.2017.7176
MLA
Guo, Y., Liang, Z., Hou, X., Zhang, Z."Diverse gene expression patterns in response to anticancer drugs between human and mouse cell lines revealed by a comparative transcriptomic analysis". Molecular Medicine Reports 16.4 (2017): 4469-4474.
Chicago
Guo, Y., Liang, Z., Hou, X., Zhang, Z."Diverse gene expression patterns in response to anticancer drugs between human and mouse cell lines revealed by a comparative transcriptomic analysis". Molecular Medicine Reports 16, no. 4 (2017): 4469-4474. https://doi.org/10.3892/mmr.2017.7176