ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway

  • Authors:
    • Yikun Qu
    • Chunfang Hao
    • Jian Xu
    • Zhuoxin Cheng
    • Weiqun Wang
    • Hong Liu
  • View Affiliations

  • Published online on: August 7, 2017     https://doi.org/10.3892/mmr.2017.7180
  • Pages: 5036-5042
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Abstract

Breast cancer is a very common malignant tumor, whose incidence ranks the first among various types of cancer in women worldwide. An important hallmark of cancer is the activation of oncogenes, which lead to overgrowth of cancer cells. Therefore, it is necessary to identify the critical genes involved in regulating the progression of breast cancer and elucidate the corresponding molecular mechanisms. The present study demonstrated that integrin‑linked kinase (ILK) overexpression promoted cell proliferation and growth in MCF‑7 cells, while ILK knockdown led to growth arrest in MDA‑MB‑231 cells. In addition, activation of the phosphoinositide 3‑kinase (PI3K)/Akt pathway was positively regulated by ILK, suggesting that the regulatory effects of ILK on cell growth and proliferation may be at least in part mediated by PI3K/Akt signaling. These results indicated that ILK promoted cell proliferation and growth in breast cancer cells through activation of the PI3K/Akt pathway, suggesting that ILK may be considered to be a potential therapeutic target for the therapy of breast cancer in the future.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Qu Y, Hao C, Xu J, Cheng Z, Wang W and Liu H: ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway. Mol Med Rep 16: 5036-5042, 2017
APA
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., & Liu, H. (2017). ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway. Molecular Medicine Reports, 16, 5036-5042. https://doi.org/10.3892/mmr.2017.7180
MLA
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., Liu, H."ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway". Molecular Medicine Reports 16.4 (2017): 5036-5042.
Chicago
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., Liu, H."ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway". Molecular Medicine Reports 16, no. 4 (2017): 5036-5042. https://doi.org/10.3892/mmr.2017.7180