Open Access

Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signal

  • Authors:
    • Mei Xiang
    • Zihong Chen
    • Donghong Yang
    • Haiwen Li
    • Yufang Zuo
    • Jingjing Li
    • Wendian Zhang
    • Hechao Zhou
    • Danxian Jiang
    • Zumin Xu
    • Zhonghua Yu
  • View Affiliations

  • Published online on: June 12, 2017     https://doi.org/10.3892/ol.2017.6372
  • Pages: 1933-1938
  • Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is one of the leading causes of cancer‑associated mortality, worldwide. The overall survival rate remains low, but progress has been made in improving the diagnosis and treatment of lung cancer over the past decades. Niclosamide, a salicylanilide derivative used for the treatment of tapeworm infections, is safe, well tolerated, inexpensive and readily available. Previous studies have identified niclosamide as a potential anticancer agent. The present study demonstrated that niclosamide enhanced the effect of irradiation by inhibiting the hypoxia‑inducible factor‑1α/vascular endothelial growth factor signaling pathway. These findings suggest that niclosamide may be a promising candidate for clinical evaluation as part of a combined regimen for the treatment of non‑small cell lung cancer.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xiang M, Chen Z, Yang D, Li H, Zuo Y, Li J, Zhang W, Zhou H, Jiang D, Xu Z, Xu Z, et al: Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signal. Oncol Lett 14: 1933-1938, 2017
APA
Xiang, M., Chen, Z., Yang, D., Li, H., Zuo, Y., Li, J. ... Yu, Z. (2017). Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signal. Oncology Letters, 14, 1933-1938. https://doi.org/10.3892/ol.2017.6372
MLA
Xiang, M., Chen, Z., Yang, D., Li, H., Zuo, Y., Li, J., Zhang, W., Zhou, H., Jiang, D., Xu, Z., Yu, Z."Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signal". Oncology Letters 14.2 (2017): 1933-1938.
Chicago
Xiang, M., Chen, Z., Yang, D., Li, H., Zuo, Y., Li, J., Zhang, W., Zhou, H., Jiang, D., Xu, Z., Yu, Z."Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signal". Oncology Letters 14, no. 2 (2017): 1933-1938. https://doi.org/10.3892/ol.2017.6372