Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer

  • Authors:
    • Changcai Teng
    • Hong Zheng
  • View Affiliations

  • Published online on: August 3, 2017     https://doi.org/10.3892/ol.2017.6714
  • Pages: 4277-4281
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRs) serve important roles in cancer genesis and progression. The expression of miR‑1908 has been reported in a number of types of cancer; however, the clinical significance of miR‑1908 in human ovarian cancer (OC) remains unclear. A total of 491 patients with OC from The Cancer Genome Atlas project cohort were selected and divided into two groups according to the median expression level of miR‑1908. Univariate and multivariate analyses, using the Kaplan‑Meier method and Cox regression, were performed to identify the characteristics that predict OC prognosis. Bioinformatics tools were used to identify potential targets of miR‑1908. It was identified that the low expression of miR‑1908 is associated with a poor prognosis for OC (P<0.05). The potential target genes of miR‑1908 included podocan‑like 1, JunB AP‑1 transcription factor subunit, homeobox B8, SET binding factor 1 and sirtuin 2; high expression of these five genes additionally predicted a poor prognosis. These results suggest that miR‑1908 may be a suitable target for the development of novel approaches in OC diagnosis and therapy in the future.
View Figures
View References

Related Articles

Journal Cover

October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Teng C and Teng C: Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer. Oncol Lett 14: 4277-4281, 2017
APA
Teng, C., & Teng, C. (2017). Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer. Oncology Letters, 14, 4277-4281. https://doi.org/10.3892/ol.2017.6714
MLA
Teng, C., Zheng, H."Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer". Oncology Letters 14.4 (2017): 4277-4281.
Chicago
Teng, C., Zheng, H."Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer". Oncology Letters 14, no. 4 (2017): 4277-4281. https://doi.org/10.3892/ol.2017.6714