Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma

  • Authors:
    • Susumu Matsukuma
    • Oh Takahashi
    • Yoshitaka Utsumi
    • Masaki Tsuda
    • Kosuke Miyai
    • Kenji Okada
    • Hiroaki Takeo
  • View Affiliations

  • Published online on: August 23, 2017     https://doi.org/10.3892/ol.2017.6804
  • Pages: 4918-4922
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Herein is described a unique case of esophageal cancer mimicking acantholytic squamous cell carcinoma (SCC). The patient succumbed to the disease within one month of diagnosis. Autopsy revealed a 10‑cm esophageal tumor, characterized by prominent acantholysis‑like areas composed of discohesive cancer cells, along with nested growth of SCC. These discohesive cancer cells focally exhibited pagetoid extension into adjacent esophageal epithelium, comprised ~60% of the esophageal tumor volume and had widely metastasized to the lungs, chest wall, liver, spleen, right adrenal gland, bones and lymph nodes. No metastases of SCC were observed. SCC cells were immunohistochemically positive for keratin 5/6 and E‑cadherin and were negative for mucin and carcinoembryonic antigen (CEA). However, the discohesive cancer cells exhibited negativity for keratin 5/6, positivity for mucin and CEA, and diminished or no immunostaining for E‑cadherin. Thus, these discohesive cells represented true adenocarcinomatous differentiation rather than acantholytic SCC cells. It was concluded that this tumor was an esophageal adenosquamous carcinoma with ‘pseudo’‑acantholytic adenocarcinoma components, which should be considered as a rare but distinctive type of aggressive cancer.
View Figures
View References

Related Articles

Journal Cover

October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Matsukuma S, Takahashi O, Utsumi Y, Tsuda M, Miyai K, Okada K and Takeo H: Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. Oncol Lett 14: 4918-4922, 2017
APA
Matsukuma, S., Takahashi, O., Utsumi, Y., Tsuda, M., Miyai, K., Okada, K., & Takeo, H. (2017). Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. Oncology Letters, 14, 4918-4922. https://doi.org/10.3892/ol.2017.6804
MLA
Matsukuma, S., Takahashi, O., Utsumi, Y., Tsuda, M., Miyai, K., Okada, K., Takeo, H."Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma". Oncology Letters 14.4 (2017): 4918-4922.
Chicago
Matsukuma, S., Takahashi, O., Utsumi, Y., Tsuda, M., Miyai, K., Okada, K., Takeo, H."Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma". Oncology Letters 14, no. 4 (2017): 4918-4922. https://doi.org/10.3892/ol.2017.6804