Open Access

Common mental disorders and association with telomere length (Review)

  • Authors:
    • E. Vakonaki
    • K. Tsiminikaki
    • S. Plaitis
    • P. Fragkiadaki
    • D. Tsoukalas
    • I. Katsikantami
    • G. Vaki
    • M. N. Tzatzarakis
    • D. A. Spandidos
    • A. M. Tsatsakis
  • View Affiliations

  • Published online on: January 8, 2018     https://doi.org/10.3892/br.2018.1040
  • Pages:111-116
  • Copyright: © Vakonaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Telomeres are repeated 5'-TTAGGG-3' sequences at the end of chromosomes, which maintain genomic stability. Their length is related to a number of diseases that affect humans. Apart from cancer, cardiovascular diseases, diabetes and other, telomere length has been associated with chronic diseases. Chronic mental illness includes various types of mental disorders with the most common being depression, schizophrenia and stress‑anxiety. The aim of this review is to summarize the current state of knowledge on the role of telomeres in these disorders and to compare telomere length variations in patients receiving medication and patients not taking treatment. Most studies report reduced telomere length in patients suffering from mental disorders, compared to the general population. Since the factors that can affect telomere length are various, more experiments and investigations are required to understand the general impact of different factors on telomere length.

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February 2018
Volume 8 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
APA
Vakonaki, E., Tsiminikaki, K., Plaitis, S., Fragkiadaki, P., Tsoukalas, D., Katsikantami, I. ... Tsatsakis, A.M. (2018). Common mental disorders and association with telomere length (Review). Biomedical Reports, 8, 111-116. https://doi.org/10.3892/br.2018.1040
MLA
Vakonaki, E., Tsiminikaki, K., Plaitis, S., Fragkiadaki, P., Tsoukalas, D., Katsikantami, I., Vaki, G., Tzatzarakis, M. N., Spandidos, D. A., Tsatsakis, A. M."Common mental disorders and association with telomere length (Review)". Biomedical Reports 8.2 (2018): 111-116.
Chicago
Vakonaki, E., Tsiminikaki, K., Plaitis, S., Fragkiadaki, P., Tsoukalas, D., Katsikantami, I., Vaki, G., Tzatzarakis, M. N., Spandidos, D. A., Tsatsakis, A. M."Common mental disorders and association with telomere length (Review)". Biomedical Reports 8, no. 2 (2018): 111-116. https://doi.org/10.3892/br.2018.1040