1. The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
    Marjorie Reyes-Farias et al, 2019, IJMS CrossRef
  2. PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer
    Reem Saleh et al, 2019, Cancers CrossRef
  3. Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer—Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy
    Andreas Schneeweiss et al, 2019, Cancers CrossRef
  4. In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds
    Sean N. O’Byrne et al, 2020, Molecules CrossRef
  5. Rosemary Extract Inhibits Proliferation, Survival, Akt, and mTOR Signaling in Triple-Negative Breast Cancer Cells
    Alina Jaglanian et al, 2020, IJMS CrossRef
  6. Spotlight on AKT: Current Therapeutic Challenges
    Ina Landel et al, 2020, ACS Med. Chem. Lett. CrossRef
  7. In Silico Screening Anticancer of Six Triterpenoids toward miR-494 and TNF-α Targets
    Vikra Ardiansyah Zaini et al, 2020, J. Kim. Sains Apl. CrossRef
  8. Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer.
    Rajani Rai et al, 2020, Cancers (Basel) CrossRef

  9. Regulation of Autophagy by Non-Steroidal Anti-Inflammatory Drugs in Cancer


    Xiangjie Fu et al, 2020, CMAR CrossRef
  10. Characterization of the in vitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line
    Higor Lopes Nunes et al, 2020, Journal of Toxicology and Environmental Health, Part A CrossRef
  11. Bromosulfophthalein Suppresses Inflammatory Effects in Lipopolysaccharide-Stimulated RAW264.7 Macrophages
    Fuai Cui et al, 2020, Immunopharmacology and Immunotoxicology CrossRef
  12. Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity
    Indiwari Gopallawa et al, 2020, WJBC CrossRef
  13. Vav1 Down-Modulates Akt2 Expression in Cells from Pancreatic Ductal Adenocarcinoma: Nuclear Vav1 as a Potential Regulator of Akt Related Malignancy in Pancreatic Cancer
    Silvia Grassilli et al, 2020, Biomedicines CrossRef
  14. Methionine Supplementation Affects Metabolism and Reduces Tumor Aggressiveness in Liver Cancer Cells
    Farida Tripodi et al, 2020, Cells CrossRef
  15. Onosma bracteata Wall. induces G0/G1 arrest and apoptosis in MG-63 human osteosarcoma cells via ROS generation and AKT/GSK3β/cyclin E pathway.
    Ajay Kumar et al, 2021, Environ Sci Pollut Res Int CrossRef
  16. KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity
    Xizi Jiang et al, 2020, Cell Biosci CrossRef
  17. Deciphering the Importance of Glycosphingolipids on Cellular and Molecular Mechanisms Associated with Epithelial-to-Mesenchymal Transition in Cancer
    Cécile Cumin et al, 2021, Biomolecules CrossRef
  18. Inhibition of PI3K Isoform p110γ Increases Both Anti-Tumor and Immunosuppressive Responses to Aggressive Murine Head and Neck Squamous Cell Carcinoma with Low Immunogenicity
    Kelvin Anderson et al, 2021, Cancers CrossRef
  19. Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
    Sarah Christine Elisabeth Wright et al, 2021, Cancers CrossRef
  20. AKT Inhibitors: The Road Ahead to Computational Modeling-Guided Discovery
    Amit Kumar Halder et al, 2021, IJMS CrossRef
  21. Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling
    Diem Thi Ngoc Huynh et al, 2021, Cancers CrossRef
  22. Fuzheng Jiedu Xiaoji formulation inhibits hepatocellular carcinoma progression in patients by targeting the AKT/CyclinD1/p21/p27 pathway
    Xue Yang et al, 2021, Phytomedicine CrossRef
  23. OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo
    Leilei Ding et al, 2021, DDDT CrossRef
  24. Recent Updates on the Involvement of PI3K/AKT/mTOR Molecular Cascade in the Pathogenesis of Hyperproliferative Skin Disorders.
    Laura Mercurio et al, 2021, Front Med (Lausanne) CrossRef
  25. Kisspeptin-10 Administration Regulates mTOR and AKT Activities and Oxidative Stress in Mouse Cardiac Tissue
    H. Akkaya, 2021, J Evol Biochem Phys CrossRef
  26. Aldo-Keto Reductase 1C3 Mediates Chemotherapy Resistance in Esophageal Adenocarcinoma via ROS Detoxification
    Chenghui Zhou et al, 2021, Cancers CrossRef
  27. Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2
    Rizwan Ali et al, 2021, Cells CrossRef
  28. Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component
    Shirong Zhang et al, 2021, Front. Oncol. CrossRef
  29. Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network
    Milad Ghomlaghi et al, 2021, IJMS CrossRef
  30. Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis
    Alison L Kearney et al, 2021 CrossRef
  31. Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer
    Huayi Li et al, 2021, Cancers CrossRef
  32. The Green Anti-Cancer Weapon. The Role of Natural Compounds in Bladder Cancer Treatment
    Paulina Wigner et al, 2021, IJMS CrossRef
  33. Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention
    Nazanin Momeni Roudsari et al, 2021, Pharmaceutics CrossRef
  34. Kir4.1 may represent a novel therapeutic target for diabetic retinopathy (Review)
    Xiaoyu Li et al, 2021, Exp Ther Med CrossRef
  35. Insights into Mechanisms of Tumorigenesis in Neuroendocrine Neoplasms
    Lorenza Pastorino et al, 2021, IJMS CrossRef
  36. null
    Adriana Monroy et al, 2021 CrossRef
  37. Aloe-Emodin-Mediated Photodynamic Therapy Induces Apoptosis in Basal Cell Carcinoma Cells via Activation of ERK/JNK Signaling Pathway
    Woodvine Otieno Odhiambo et al, 2021, International Journal of Photoenergy CrossRef
  38. The Potential of Hsp90 in Targeting Pathological Pathways in Cardiac Diseases
    Richard J. Roberts et al, 2021, JPM CrossRef
  39. Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders
    Xufen Yu et al, 2021, J. Med. Chem. CrossRef
  40. A Century of Fractionated Radiotherapy: How Mathematical Oncology Can Break the Rules
    Nima Ghaderi et al, 2022, IJMS CrossRef
  41. NSAIDs and Cancer Resolution: New Paradigms beyond Cyclooxygenase
    Oluwafunke R. Kolawole et al, 2022, IJMS CrossRef
  42. null
    Adriana Monroy et al, 2022 CrossRef
  43. Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship Studies
    Xufen Yu et al, 2022, J. Med. Chem. CrossRef
  44. Toward Development of a Diabetic Synovium Culture Model
    Neeraj Sakhrani et al, 2022, Front. Bioeng. Biotechnol. CrossRef
  45. Carboxyl-Functionalized Carbon Nanotubes Loaded with Cisplatin Promote the Inhibition of PI3K/Akt Pathway and Suppress the Migration of Breast Cancer Cells
    Madalina Andreea Badea et al, 2022, Pharmaceutics CrossRef
  46. Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides.
    Hsueh-wei Chang, 0 CrossRef
  47. A Dual Anti-Inflammatory and Anti-Proliferative 3-Styrylchromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling
    Sei-ichi Tanuma et al, 2022, IJMS CrossRef
  48. Dehydrocrenatidine Induces Liver Cancer Cell Apoptosis by Suppressing JNK-Mediated Signaling
    Bharath Kumar Velmurugan et al, 2022, Pharmaceuticals CrossRef
  49. Dasatinib enhances curcumin-induced cytotoxicity, apoptosis and protective autophagy in human schwannoma cells HEI-193: The role of Akt/mTOR/p70S6K signalling pathway
    Pengfei Pang et al, 2022 CrossRef
  50. An effective AKT inhibitor-PARP inhibitor combination therapy for recurrent ovarian cancer
    Jing Xu et al, 2022, Cancer Chemother Pharmacol CrossRef
  51. Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population
    Efthimios Dimitrakis et al, 2022, Exp Ther Med CrossRef
  52. Protective Effect of PI3K/AKT Signaling Pathway in Ischemic Stroke
    昭 赵, 2022, ACM CrossRef
  53. Antioxidant Activity and Inhibitory Effects of Black Rice Leaf on the Proliferation of Human Carcinoma Cells
    Chorpaka Thepthanee et al, 2022, BioMed Research International CrossRef
  54. Acridone Derivatives from Atalantia monophyla Inhibited Cancer Cell Proliferation through ERK Pathway
    Wen-Yong Gao et al, 2022, Molecules CrossRef
  55. Novel Insights Into Mesothelioma Therapy: Emerging Avenues and Future Prospects
    Lukasz Kuryk et al, 2022, Front. Oncol. CrossRef
  56. Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
    Xin Ma et al, 2022, Front. Cell Dev. Biol. CrossRef
  57. Cytotoxic Effects of the Schweinfurthin Analog 5′-Methylschweinfurthin G in Malignant Plasma Cells
    Barbara Manfredi et al, 2022, Pharmacology CrossRef
  58. JIB-04, a Pan-Inhibitor of Histone Demethylases, Targets Histone-Lysine-Demethylase-Dependent AKT Pathway, Leading to Cell Cycle Arrest and Inhibition of Cancer Stem-Like Cell Properties in Hepatocellular Carcinoma Cells
    Jina Lee et al, 2022, IJMS CrossRef
  59. A Comprehensive Review on the Anti-Cancer Effects of Oleuropein
    Sabreen Rishmawi et al, 2022, Life CrossRef
  60. Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells
    Javier Florido et al, 2022, Antioxidants CrossRef
  61. Role of Collagen Regulators in Cancer Treatment: A Comprehensive Review
    Tanuja Angre et al, 2022, ACAMC CrossRef
  62. Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer
    Se Hyo Jeong et al, 2022, IJMS CrossRef
  63. Repression of Memo1, a Novel Target of Human Papillomavirus Type 16 E7, Increases Cell Proliferation in Cervical Cancer Cells.
    Oscar Trejo-Cerro et al, 2022, J Virol CrossRef
  64. Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A
    Vidhya A Nair et al, 2022, IJMS CrossRef
  65. Antipsychotic Drug Fluphenazine against Human Cancer Cells
    Diana Duarte et al, 2022, Biomolecules CrossRef
  66. 7-Epitaxol induces apoptosis in cisplatin-resistant head and neck squamous cell carcinoma via suppression of AKT and MAPK signalling.
    Hui-Ju Yang et al, 2022, J Cell Mol Med CrossRef
  67. Uncovering the Key Targets and Therapeutic Mechanisms of Qizhen Capsule in Gastric Cancer through Network Pharmacology and Bioinformatic Analyses
    Wanmei Zhou et al, 2022, Computational and Mathematical Methods in Medicine CrossRef
  68. Tetrandrine inhibits migration and invasion of BGC ‐823 and MKN ‐45 cells by regulating PI3K / AKT / mTOR signaling pathway
    Wanli Xue et al, 2023, Chem Biol Drug Des CrossRef
  69. Distinguish the Characteristic Mechanism of 3 Drug Pairs of Corydalis Rhizome in Ameliorating Angina Pectoris: Network Pharmacology and Meta-Analysis
    Zhenwei Zhai et al, 2023, Natural Product Communications CrossRef
  70. Sodium Butyrate Ameliorates Fluorosis-Induced Neurotoxicity by Regulating Hippocampal Glycolysis In Vivo
    Yangjie Li et al, 2023, Biol Trace Elem Res CrossRef
  71. Overexpression of lnc-ERP44-3:6 Causes Cell Death and Sensitivity to Cisplatin in Breast Cancer Cell Lines
    Elda A. Flores-Contreras et al, 2021 CrossRef
  72. The inhibitory effect and mechanism of Resina Draconis on the proliferation of MCF-7 breast cancer cells: a network pharmacology-based analysis
    Yana Lv et al, 2023, Sci Rep CrossRef
  73. Systemic treatment for unresectable hepatocellular carcinoma
    Wattana Leowattana et al, 2023, World J Gastroenterol CrossRef
  74. Systemic treatment for unresectable hepatocellular carcinoma
    Wattana Leowattana et al, 2023, World J Gastroenterol CrossRef
  75. The interplay between androgens and the immune response in polycystic ovary syndrome
    Sania Shabbir et al, 2023, J Transl Med CrossRef
  76. Study on Molecular Anti-tumor Mechanism of 2-Thiohydantoin Derivative based on Molecular Docking and Bioinformatic Analyses
    Ali AbdulWahid AbdulHussein Al-Shawi et al, 2023, CTMC CrossRef
  77. Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer.
    Feng Ye et al, 2023, Mol Cancer CrossRef
  78. Exploring antiproliferative activities and kinase profile of ortho‐substituted N‐(4‐(2‐(benzylamino)‐2‐oxoethyl)phenyl)benzamides
    Yosra A. Muhammad et al, 2023, Chem Biol Drug Des CrossRef
  79. Does the Presence of Heavy Metals Influence the Gene Expression and Oxidative Stress in Bladder Cancer?
    Eslam El-Agrody et al, 2023, Biol Trace Elem Res CrossRef
  80. Role of EGFR and FASN in breast cancer progression
    Suchi Chaturvedi et al, 2023, J. Cell Commun. Signal. CrossRef
  81. Sodium-glucose cotransporter-2 inhibitors for hypergycemia in phosphoinositide 3-kinase pathway inhibition
    Michael A. Weintraub et al, 2024, Breast Cancer Res Treat CrossRef
  82. TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation.
    Kaiwen Zhang et al, 2024, Cancer Biol Ther CrossRef
  83. Elucidating the role of intrinsic adenosine A1 receptors in acute alcoholism using human-induced pluripotent stem cell-derived hepatocytes
    Takako Nagata et al, 2024 CrossRef
  84. Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway
    Kening Sun et al, 2024 CrossRef
  85. A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer
    Nur Farisya Shamsudin et al, 2024, Future Medicinal Chemistry CrossRef
  86. ITIH1 suppresses carcinogenesis in renal cell carcinoma through regulation of the NF‑κB signaling pathway
    Jing Gao et al, 2024, Exp Ther Med CrossRef
  87. Metformin as a Potential In Vitro Anticancer Modulator of Adenosine Monophosphate Kinase: A Review
    A. G. R. Greshamali Jinadasa et al, 2024, International Journal of Breast Cancer CrossRef
  88. Streptococcus pneumoniae and Influenza (H1N1) Virus Genome Study against Human Genome Sequences-BLASTn and DAVID Analysis
    Mark Christopher Arokiaraj et al, 2024, SEE J Immunol CrossRef
  89. Effects of Exercise Training on Prostate Cancer: Current Evidence and Potential Molecular Mechanisms
    Madison Webber et al, 2024, Advanced Exercise and Health Science CrossRef
  90. null
    Milica M. Borovcanin et al, 2024 CrossRef
  91. Lactoferrin Protects Against Rotenone-Induced Toxicity in Dopaminergic SH-SY5Y Cells through the Modulation of Apoptotic-Associated Pathways
    Shin Jie Yong et al, 2024, J Mol Neurosci CrossRef
  92. Classifying covalent protein binders by their targeted binding site
    Walaa A. Bedewy et al, 2024, Bioorganic & Medicinal Chemistry Letters CrossRef