1. Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins
   Selahattin Can Ozcan et al, 2024, Scientific Reports CrossRef
2. PLK4 Reflects Extrathyroidal Invasion, High Tumor Stage And Poor Prognosis in Papillary Thyroid Carcinoma Patients
   Xiaonan Hu et al, 2024, Biomarkers in Medicine CrossRef
3. A Redox‐Triggered Bispecific Supramolecular Nanomedicine Based on Peptide Self‐Assembly for High‐Efficacy and Low‐Toxic Cancer Therapy
   Da‐Song Yang et al, 2020, Advanced Functional Materials CrossRef
4. Tumor polo-like kinase 4 protein expression reflects lymphovascular invasion, higher Federation of Gynecology and Obstetrics stage, and shortened survival in endometrial cancer patients who undergo surgical resection
   Qinyan Zhao et al, 2024, BMC Women's Health CrossRef
5. Modelling the Functions of Polo-Like Kinases in Mice and Their Applications as Cancer Targets with a Special Focus on Ovarian Cancer
   Monika Kressin et al, 2021, Cells CrossRef
6. Triple deletion ofTP53, PCNT, andCEP215promotes centriole amplification in the M phase
   Gee In Jung et al, 2021, Cell Cycle CrossRef
7. Expanding roles of centrosome abnormalities in cancers
   Soohyun Song et al, 2023, BMB Reports CrossRef
8. Clinical Significance of Polo-Like Kinase 4 as a Marker for Advanced Tumor Stage and Dismal Prognosis in Patients With Surgical Gastric Cancer
   Ting Cao et al, 2020, Technology in Cancer Research & Treatment CrossRef
9. CircKIF2A contributes to cell proliferation, migration, invasion and glycolysis in human neuroblastoma by regulating miR-129-5p/PLK4 axis
   Yiheng Yang et al, 2021, Molecular and Cellular Biochemistry CrossRef
10. Role of non-coding RNAs in neuroblastoma
    Ali Arash Anoushirvani et al, 2023, Cancer Gene Therapy CrossRef
11. Role of Polo-Like Kinase 4 (PLK4) in Epithelial Cancers and Recent Progress in its Small Molecule Targeting for Cancer Management
    Debra R. Garvey et al, 2021, Molecular Cancer Therapeutics CrossRef
12. FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity
    Karineh Kazazian et al, 2020, Communications Biology CrossRef
13. Identification of Prognostic Markers and Potential Therapeutic Targets in Gastric Adenocarcinoma by Machine Learning Based on mRNAsi Index
    Si Hong Guo et al, 2022, Journal of Oncology CrossRef
14. TEC kinase stabilizes PLK4 to promote liver cancer metastasis
    Sai-Fung Yeung et al, 2022, Cancer Letters CrossRef
15. Non-mitotic functions of polo-like kinases in cancer cells
    Christopher A. Raab et al, 2021, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
16. Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4
    Karuna Mittal et al, 2022, Molecular Cancer Research CrossRef
17. Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4
    Chenggang Zhang et al, 2023, iScience CrossRef
18. Polo‑like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
    Zhengang Duan et al, 2022, Oncology Letters CrossRef
19. Comprehensive analysis of differentially expressed genes reveals the promotive effects of UBE2T on colorectal cancer cell proliferation
    Min Luo et al, 2021, Oncology Letters CrossRef
20. Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified Breast Cancer
    Yin Sun et al, 2023, Journal of Medicinal Chemistry CrossRef
21. Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype
    Irina Fonseca et al, 2023, Cell Death & Disease CrossRef
22. Generation and Fates of Supernumerary Centrioles in Dividing Cells
    Byungho Shin et al, 2021, Molecules and Cells CrossRef
23. Discovery of Polo-like Kinase 4 Inhibitors for the Treatment of Cancer: A Mini Patent Review
    Zhouling Xie et al, 2023, Mini-Reviews in Medicinal Chemistry CrossRef
24. Developmental and tissue‐specific roles of mammalian centrosomes
    Charlotte Meyer‐Gerards et al, 2024, The FEBS Journal CrossRef
25. Role of Hub Genes in the Occurrence and Development of Testicular Cancer Based on Bioinformatics
    Chunlei Zhang et al, 2022, International Journal of General Medicine CrossRef
26. Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia
    Yin Sun et al, 2023, Journal of Medicinal Chemistry CrossRef
27. Aberrant expression of polo‑like kinase 4 in renal cell carcinoma: Association with clinicopathological characteristics and long‑term survival
    Wenxia Jiang et al, 2022, Oncology Letters CrossRef
28. Keep Calm and Carry on with Extra Centrosomes
    Batuhan Mert Kalkan et al, 2022, Cancers CrossRef
29. Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development
    Nanako Hamada et al, 2022, Developmental Neuroscience CrossRef
30. Structure-based discovery of 1-(3-fluoro-5-(5-(3-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)-3-(pyrimidin-5-yl)urea as a potent and selective nanomolar type-II PLK4 inhibitor
    Yin Sun et al, 2022, European Journal of Medicinal Chemistry CrossRef
31. Activating transcription factor 6 (ATF6) negatively regulates Polo-like kinase 4 expression via recruiting C/EBPβ to the upstream-promoter during ER stress
    Tao Shen et al, 2020, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms CrossRef
32. Identification of 9 Gene Signatures by WGCNA to Predict Prognosis for Colon Adenocarcinoma
    Mian Yang et al, 2022, Computational Intelligence and Neuroscience CrossRef
33. Fraxetin down-regulates polo-like kinase 4 (PLK4) to inhibit proliferation, migration and invasion of prostate cancer cells through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway
    Zheng Ma et al, 2022, Bioengineered CrossRef
34. Therapeutic potential of targeting polo-like kinase 4
    Qian Lei et al, 2024, European Journal of Medicinal Chemistry CrossRef
35. Downregulation of PLK4 expression induces apoptosis and G0/G1‐phase cell cycle arrest in keloid fibroblasts
    Ru‐Lin Huang et al, 2022, Cell Proliferation CrossRef
36. Recent progress in agents targeting polo-like kinases: Promising therapeutic strategies
    Zheng Zhang et al, 2021, European Journal of Medicinal Chemistry CrossRef
37. Prognostic Prediction Using a Stemness Index-Related Signature in a Cohort of Gastric Cancer
    Xiaowei Chen et al, 2020, Frontiers in Molecular Biosciences CrossRef