1. Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)
   NIANSHUANG LI et al, 2015 CrossRef
2. Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis.
   Aurigena Antunes de Araújo et al, 2017, PLoS One CrossRef
3. Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis
   Ke-Wu Zeng et al, 2013, European Journal of Pharmacology CrossRef
4. PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells
   ZE-TAN CHEN et al, 2015 CrossRef
5. Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin‑1.
   Zhe Zhang et al, 2015, Mol Med Rep CrossRef
6. Metformin inhibits endothelial progenitor cell migration by decreasing matrix metalloproteinases, MMP-2 and MMP-9, via the AMPK/mTOR/autophagy pathway
   Wen-Dong Li et al, 2017 CrossRef
7. Targeting endothelial cell metabolism: new therapeutic prospects?
   Annalisa Zecchin et al, 2015, Front. Biol. CrossRef
8. Arctii Fructus Inhibits Colorectal Cancer Cell Proliferation and MMPs Mediated Invasion via AMPK
   Yo-Han Han et al, 2017, Am. J. Chin. Med. CrossRef
9. Association between metformin prescription and growth rates of abdominal aortic aneurysms
   J. Golledge et al, 2017, Br J Surg CrossRef
10. Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line
    Zhihui Xiao et al, 2017, Mediators of Inflammation CrossRef
11. null
    Annele Sainio et al, 2017 CrossRef
12. Metformin
    Fernando P. de Souza Neto et al, 2017, Melanoma Research CrossRef
13. Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms.
    Nanda Gamad et al, 2018, Biomed Pharmacother CrossRef
14. Anti-diabetic drug metformin dilates retinal blood vessels through activation of AMP-activated protein kinase in rats
    Asami Mori et al, 2017, European Journal of Pharmacology CrossRef
15. Therapeutic implication of ‘Iturin A’ for targeting MD-2/TLR4 complex to overcome angiogenesis and invasion
    Goutam Dey et al, 2017, Cellular Signalling CrossRef
16. Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells
    Si Hyoung Kim et al, 2017, Endocrine CrossRef
17. Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation
    Simona Pisanti et al, 2014, The FASEB Journal CrossRef
18. Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia
    Sherin Bakhashab et al, 2018, IJMS CrossRef
19. Rosmarinic Acid Activates AMPK to Inhibit Metastasis of Colorectal Cancer
    Yo-Han Han et al, 2018, Front. Pharmacol. CrossRef
20. Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo.
    Jing Han et al, 2018, PLoS One CrossRef
21. Metformin's antitumour and anti-angiogenic activities are mediated by skewing macrophage polarization.
    Ji-Chang Wang et al, 2018, J Cell Mol Med CrossRef
22. Role of Adenosine Monophosphate-Activated Protein Kinase on Cell Migration, Matrix Contraction, and Matrix Metalloproteinase-1 and Matrix Metalloproteinase-2 Production in Nasal Polyp–Derived Fibroblasts
    Ti-Young Um et al, 2017, Am J Rhinol�Allergy CrossRef
23. Metformin does not reduce inflammation in diabetics with abdominal aortic aneurysm or at high risk of abdominal aortic aneurysm formation
    S Keisin Wang et al, 2018, Vascular CrossRef
24. Mechanistic study of the in vitro and in vivo inhibitory effects of protocatechuic acid and syringic acid on VEGF-induced angiogenesis
    Jiamiao Hu et al, 2018, J. Agric. Food Chem. CrossRef
25. Obesity and Cancer: An Angiogenic and Inflammatory Link
    Dai Fukumura et al, 2016, Microcirculation CrossRef
26. Metformin Prescription is Associated with a Reduction in the Combined Incidence of Surgical Repair and Rupture Related Mortality in Patients with Abdominal Aortic Aneurysm
    Jonathan Golledge et al, 2018, European Journal of Vascular and Endovascular Surgery CrossRef
27. Metformin inhibits estradiol and progesterone-induced decidualization of endometrial stromal cells by regulating expression of progesterone receptor, cytokines and matrix metalloproteinases
    Fang Xiong et al, 2019, Biomedicine & Pharmacotherapy CrossRef
28. Matrix metalloproteinases in patients with resistant hypertension and type 2 diabetes mellitus: relation with renal blood flow and kidney function
    A. Yu. Falkovskaya et al, 2019, Arter. gipertenz. CrossRef
29. Promoting therapeutic angiogenesis of focal cerebral ischemia using thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) in a rat model
    Qian Zhang et al, 2019, J Transl Med CrossRef
30. Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP‐2 and MMP‐9 via H19/miR‐29b‐3p and AKT/mTOR/autophagy signaling pathways
    Zhilan Chen et al, 2019, J Cell Physiol CrossRef
31. Sulfenamide and Sulfonamide Derivatives of Metformin – A New Option to Improve Endothelial Function and Plasma Haemostasis
    Magdalena Markowicz-Piasecka et al, 2019, Sci Rep CrossRef
32. Cancer prevention by targeting angiogenesis
    Adriana Albini et al, 2012, Nat Rev Clin Oncol CrossRef
33. Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5
    Yi Yan et al, 2015, Nat Commun CrossRef
34. MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway
    Mao Luo et al, 2017, Sci Rep CrossRef
35. Biguanides Exert Antitumoral Actions in Pituitary Tumor Cells Through AMPK-Dependent and -Independent Mechanisms.
    Mari C Vázquez-Borrego et al, 2019, J Clin Endocrinol Metab CrossRef
36. Preventive effect of Metformin against N-nitrosodiethylamine-initiated hepatocellular carcinoma in rats
    Muhammad Afzal et al, 2012, Saudi Pharmaceutical Journal CrossRef
37. Green tea seed extract inhibits cell migration by suppressing the epithelial-to-mesenchymal transition (EMT) process in breast cancer cells
    Jin-Nyoung Ho et al, 2013, Food Sci Biotechnol CrossRef
38. Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
    Chen Qu et al, 2014, Mol Cell Biochem CrossRef
39. Dual Roles of the AMP-Activated Protein Kinase Pathway in Angiogenesis
    null Li et al, 2019, Cells CrossRef
40. Paradoxic effects of metformin on endothelial cells and angiogenesis.
    Katiuscia Dallaglio et al, 2014, Carcinogenesis CrossRef
41. Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies.
    Silvian Tan et al, 2019, Front Immunol CrossRef
42. Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model
    Noriko Takahashi et al, 2015, Journal of Vascular Surgery CrossRef
43. Activation of AMP-Activated Protein Kinase Inhibits the Proliferation of Human Endothelial Cells
    Kelly J. Peyton et al, 2012, J Pharmacol Exp Ther CrossRef
44. Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators
    R. Lim et al, 2015, Placenta CrossRef
45. Compound C inhibits in vitro angiogenesis and ameliorates thrombin-induced endothelial barrier failure
    Dursun Gündüz et al, 2015, European Journal of Pharmacology CrossRef
46. MicroRNA-195a-3pinhibits angiogenesis by targetingMmp2in murine mesenchymal stem cells
    Fan Gao et al, 2016, Mol. Reprod. Dev. CrossRef
47. Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery.
    Shaojun Li et al, 2016, Med Sci Monit Basic Res CrossRef
48. Metformin treatment in young children with fragile X syndrome
    Hazel Maridith B. Biag et al, 2019, Mol Genet Genomic Med CrossRef
49. null
    Maritza P. Garrido et al, 2019 CrossRef
50. Metformin has a direct effect on ovarian cells that is dependent on organic cation transporters
    Mariana Di Pietro et al, 2019, Molecular and Cellular Endocrinology CrossRef
51. Metformin Effect on Endocan Biogenesis in Human Endothelial Cells Under Diabetic Condition
    Elmira Zolali et al, 2019, Archives of Medical Research CrossRef
52. Relationship between metformin and abdominal aortic aneurysm.
    Juliette Raffort et al, 2020, J Vasc Surg CrossRef
53. A review on the cardioprotective mechanisms of metformin against doxorubicin
    AH Ajzashokouhi et al, 2019, Hum Exp Toxicol CrossRef
54. Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis
    Magdalena Markowicz-Piasecka et al, 2019, Molecules CrossRef
55. An investigation into the pleiotropic activity of metformin. A glimpse of haemostasis
    Magdalena Markowicz-Piasecka et al, 2020, European Journal of Pharmacology CrossRef
56. Metformin decreases hyaluronan synthesis by vascular smooth muscle cells
    Annele Sainio et al, 2020, J Investig Med CrossRef
57. Metformin Treatment Is Associated with a Decreased Risk of Nonproliferative Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus: A Population-Based Cohort Study
    Yu-Pei Fan et al, 2020, Journal of Diabetes Research CrossRef
58. Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells
    Sung-Hee Kim et al, 2017, Oncotarget CrossRef
59. Suppression of hypoxia-induced excessive angiogenesis by metformin via elevating tumor blood perfusion
    Ji-Chang Wang et al, 2017, Oncotarget CrossRef
60. Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis
    Jichang Wang et al, 2015, Oncotarget CrossRef
61. Ginsenoside Rb1 reduces H2O2‑induced HUVEC dysfunction by stimulating the sirtuin‑1/AMP‑activated protein kinase pathway
    Zhenda Zheng et al, 2020, Mol Med Report CrossRef
62. Novel Sulfonamide-Based Analogs of Metformin Exert Promising Anti-Coagulant Effects without Compromising Glucose-Lowering Activity
    Magdalena Markowicz-Piasecka et al, 2020, Pharmaceuticals CrossRef
63. Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity
    Suliman Y. Alomar et al, 2020, International Immunopharmacology CrossRef
64. Tetragonia tetragonoides (Pall.) Kuntze Restores Blood Perfusion from Hind-Limb Ischemic Mice
    Hyun Yang et al, 2020, Applied Sciences CrossRef
65. Mechanisms of action of metformin and its regulatory effect on microRNAs related to angiogenesis
    Gang Wang et al, 2020, Pharmacological Research CrossRef
66. Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells
    Béatrice Dirat et al, 2015, Mol Cancer Ther CrossRef
67. Inhibition of angiotensin-induced aortic aneurysm by metformin in ApoE-deficient mice
    Anne Kunath et al, 2021, JVS: Vascular Science CrossRef
68. Anticancer potential of metformin: focusing on gastrointestinal cancers
    Mohammad rafi Khezri et al, 2021, Cancer Chemother Pharmacol CrossRef
69. Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice
    Dongdong Huang et al, 2021, Aging CrossRef
70. Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies
    Ali Farahi et al, 2021, Mol Cell Biochem CrossRef
71. Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs
    Nahid Alimoradi et al, 2021, Biomedicine & Pharmacotherapy CrossRef
72. Weighted Gene Co-Expression Network Analysis Reveals Key Genes and Potential Drugs in Abdominal Aortic Aneurysm
    Ke-Jia Kan et al, 2021, Biomedicines CrossRef
73. Metformin Use and the Outcome of Metastatic Renal Cell Carcinoma Treated with Sunitinib or Pazopanib
    Ondřej Fiala et al, 2021, CMAR CrossRef
74. A novel imidazolinone metformin‐methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF‐1α pathway
    Huong Nguyen et al, 2021, FASEB j. CrossRef
75. Targeting nanocomposites with anti-oxidative/inflammatory/angiogenic activities for synergistically alleviating macular degeneration
    Li-Jyuan Luo et al, 2021, Applied Materials Today CrossRef
76. Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin‐resistant prediabetes mice
    Hiromi Kominato et al, 2021, J Periodontol CrossRef
77. Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application
    Amir Mohamed Abdelhamid et al, 2022, Biomedicine & Pharmacotherapy CrossRef
78. An Update on Psychopharmacological Treatment of Autism Spectrum Disorder
    Ramkumar Aishworiya et al, 2022, Neurotherapeutics CrossRef
79. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice
    Zhongjie Fu et al, 2017, Invest. Ophthalmol. Vis. Sci. CrossRef
80. Metformin Inhibits Abdominal Aortic Aneurysm Formation through the Activation of the AMPK/mTOR Signaling Pathway
    Jiaan He et al, 2021, J Vasc Res CrossRef
81. Metformin and Angiogenesis in Cancer - Revisited.
    Joseph Kannarkatt et al, 2016, Oncology CrossRef
82. Leukocyte subtypes, gelatinases, and their tissue inhibitors in a group of subjects with asymptomatic carotid atherosclerosis
    Gregorio Caimi et al, 2022, CH CrossRef
83. Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration
    Duc Dung Nguyen et al, 2022, ACS Nano CrossRef
84. Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors?
    Belén Picatoste et al, 2023, Front. Cardiovasc. Med. CrossRef
85. The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
    Dominique E. Martin et al, 2023, Immun Ageing CrossRef
86. Effects of metformin on human gingival fibroblasts: an in vitro study
    Nouf Alshibani et al, 2023, BMC Oral Health CrossRef
87. Alteration of intestinal microbiota is associated with diabetic retinopathy and its severity: Samples collected from southeast coast Chinese
    Xue-Mei Gu et al, 2023, World J Diabetes CrossRef
88. Murine Breast Cancer Radiosensitization Using Oxygen Microbubbles and Metformin: Vessels Are the Key
    Agnieszka Drzał et al, 2023, IJMS CrossRef
89. Metformin protects retinal pigment epithelium cells against H2O2-induced oxidative stress and inflammation via the Nrf2 signaling cascade
    Qiting Feng et al, 2023, Graefes Arch Clin Exp Ophthalmol CrossRef
90. PIK3CA regulates development of diabetes retinopathy through the PI3K/Akt/mTOR pathway
    Ruijuan Guan et al, 2024, PLoS ONE CrossRef
91. The Anti-Diabetic Drug Metformin Suppresses Pathological Retinal Angiogenesis via Blocking the mTORC1 Signaling Pathway in Mice (Metformin Suppresses Pathological Angiogenesis)
    Rina Yagasaki et al, 2024, Current Eye Research CrossRef
92. Gut microbiome in diabetic retinopathy: A systematic review and meta-analysis
    Shuang Zhao et al, 2024, Microbial Pathogenesis CrossRef
93. PF-04449913 Inhibits Proliferation and Metastasis of Colorectal Cancer Cells by Down-regulating MMP9 Expression through the ERK/p65 Pathway
    Yejiao Ruan et al, 2023, CMP CrossRef
94. An Update on Psychopharmacological Treatment of Autism Spectrum Disorder
    Ramkumar Aishworiya et al, 2024, FOC CrossRef
95. Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells
    Christine Hansel et al, 2021, IJMS CrossRef
96. null
    Laura A. Potter et al, 2022 CrossRef