1. Biologic activity of cyclic and caged phosphates: a review
    Dietrich E. Lorke et al, 2017, J. Appl. Toxicol. CrossRef
  2. Synthesis and antiproliferative evaluation of novel azido nucleosides and their phosphoramidate derivatives
    Nuno M. Xavier et al, 2017 CrossRef
  3. Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice
    Hongfang Feng et al, 2017, Lab Invest CrossRef
  4. The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
    Teresinha Regina Ribeiro de Oliveira et al, 2017, Acta Cir. Bras. CrossRef
  5. Differential detection and quantification of cyclic AMP and other adenosine phosphates in live cells
    Sujoy Das et al, 2017, Chem. Commun. CrossRef
  6. Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment
    Naveen Kumar et al, 2018, Mol Cell Biochem CrossRef
  7. null
    Filomena S. G. Silva et al, 2018 CrossRef
  8. Dual-Functionalized Calcium Nanocomplexes for Transfection of Cancerous and Stem Cells: Low Molecular Weight Polycation-mediated Colloidal Stability and ATP-mediated Endosomal Release
    Yeon Su Choi et al, 2018, Journal of Industrial and Engineering Chemistry CrossRef
  9. Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system
    Jane A Mitchell et al, 2018, British Journal of Pharmacology CrossRef
  10. “Riddle Me This”: Substrate Channeling Solves the Paradigms of cAMP-Dependent Activation of PKA
    César A. Ramírez-Sarmiento, 2017, Biophysical Journal CrossRef
  11. cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer
    Naveen Kumar et al, 2018 CrossRef
  12. Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain
    Grażyna Chłoń-Rzepa et al, 2018, European Journal of Medicinal Chemistry CrossRef
  13. null
    Walter Gottlieb Land, 2018 CrossRef
  14. The Arabidopsis thaliana K+-Uptake Permease 5 (AtKUP5) Contains a Functional Cytosolic Adenylate Cyclase Essential for K+ Transport
    Inas Al-Younis et al, 2018, Front. Plant Sci. CrossRef
  15. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
    Irina V. Tcymbarevich et al, 2019, BMC Gastroenterol CrossRef
  16. Cyclic AMP-dependent protein kinase A and EPAC mediate VIP and secretin stimulation of PAK4 and activation of Na+,K+-ATPase in pancreatic acinar cells
    Irene Ramos-Alvarez et al, 2019, American Journal of Physiology-Gastrointestinal and Liver Physiology CrossRef
  17. IPP-1 controls Akt/CREB phosphorylation extension in A2a adenosine receptor signaling cascade in MIN6 Pancreatic β-cell line
    Mohammad Keyvanloo Shahrestanaki et al, 2019, European Journal of Pharmacology CrossRef
  18. cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis
    Ruochan Chen et al, 2019, Sci. Adv. CrossRef
  19. null
    Eliza Oprea et al, 2019 CrossRef
  20. Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
    Selena Vigano et al, 2019, Front. Immunol. CrossRef
  21. Transforming Growth Factor-β1 Decreases β2-Agonist–induced Relaxation in Human Airway Smooth Muscle
    Christie A. Ojiaku et al, 2019, Am J Respir Cell Mol Biol CrossRef
  22. Plant Probiotic Bacterial Endophyte, Alcaligenes faecalis, Modulates Plant Growth and Forskolin Biosynthesis in Coleus forskohlii
    Anthati Mastan et al, 2019, Probiotics & Antimicro. Prot. CrossRef
  23. Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention
    Víctor M. Muñoz-Pérez et al, 2019, CPB CrossRef
  24. Cardiac function modulation depends on the A‐kinase anchoring protein complex
    Yan‐Rong Zhu et al, 2019, J Cell Mol Med CrossRef
  25. null
    Nuno M Xavier, 2017 CrossRef
  26. Transcriptomic profiling of gamma ray induced mutants from the CGL1 human hybrid cell system reveals novel insights into the mechanisms of radiation-induced carcinogenesis
    Jake Pirkkanen et al, 2019, Free Radical Biology and Medicine CrossRef
  27. null
    Michael J. McPherson et al, 2020 CrossRef
  28. Cyclic nucleotides and myometrial contractility
    Damian D Guerra et al, 2020, Current Opinion in Physiology CrossRef
  29. Physical exercise and catecholamines response: benefits and health risk: possible mechanisms
    Joanna Kruk et al, 2020, Free Radical Research CrossRef
  30. Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis
    Sonu Kashyap et al, 2020 CrossRef
  31. Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update
    Meenu Mehta et al, 2020, Inflammopharmacol CrossRef
  32. Progesterone/Org inhibits lung adenocarcinoma cell growth via membrane progesterone receptor alpha
    Jian Xiao et al, 2020, Thorac Cancer CrossRef
  33. Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome
    Lien D. Nguyen et al, 2020, Proc Natl Acad Sci USA CrossRef
  34. Stability of regulatory T cells in T helper 2–biased allergic airway diseases
    Feng Lan et al, 2020, Allergy CrossRef
  35. Genome‐wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology
    Kwangsik Nho et al, 2020, Alzheimer's & Dementia CrossRef
  36. The immunomodulatory role of PDEs inhibitors in immune cells: therapeutic implication in rheumatoid arthritis
    YuFei He et al, 2020, Pharmacological Research CrossRef
  37. Chemical Biology Toolbox for Studying Pancreatic Islet Function – A Perspective
    Julia Huey et al, 2020, Cell Chemical Biology CrossRef
  38. Role of Akt signaling pathway regulation in the speckled mousebird (Colius striatus) during torpor displays tissue specific responses
    StuartR. Green et al, 2020, Cellular Signalling CrossRef
  39. Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis
    Suzanne E. Eldridge et al, 2020, Sci. Transl. Med. CrossRef
  40. Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey
    Alireza Tafazoli et al, 2021, JCM CrossRef
  41. ADeditome provides the genomic landscape of A-to-I RNA editing in Alzheimer’s disease
    Sijia Wu et al, 2021 CrossRef
  42. Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis
    Mark J. Turner et al, 2021, Pharmacology & Therapeutics CrossRef
  43. Dual Inhibition of Ornithine Decarboxylase and A1 Adenosine Receptor Efficiently Suppresses Breast Tumor Cells
    Hongyan Ma et al, 2021, Front. Oncol. CrossRef
  44. Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling
    Basel A. Abdel-Wahab et al, 2021, Food and Chemical Toxicology CrossRef
  45. Changes in metabolite concentrations in the abdominal muscle of the kuruma shrimp Marsupenaeus japonicus in response to different salinities
    Hiroki Koyama et al, 2021, Fish Sci CrossRef
  46. Roflumilast as a Potential Therapeutic Agent for Cecal Ligation and Puncture-Induced Septic Lung Injury
    Zafer Bayraktutan et al, 2021, Journal of Investigative Surgery CrossRef
  47. Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19
    Ki Kwang Oh et al, 2021, Sci Rep CrossRef
  48. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation
    Ian M. Cartwright et al, 2021, Proc Natl Acad Sci USA CrossRef
  49. Modulation of Cyclic AMP Levels in Fallopian Tube Cells by Natural and Environmental Estrogens
    Marinella Rosselli et al, 2021, Cells CrossRef
  50. Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis.
    Shuo Yu et al, 2021, Mol Metab CrossRef
  51. Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases
    Qiangqiang Zheng et al, 2021 CrossRef
  52. The Small Molecule H89 Inhibits Chlamydia Inclusion Growth and Production of Infectious Progeny
    Karissa J. Muñoz et al, 2021, Infect Immun CrossRef
  53. Iodothyronine deiodinase 2 (DiO2) regulates trophoblast cell line cycle, invasion and apoptosis; and its downregulation is associated with early recurrent miscarriage
    Enoch Appiah Adu-Gyamfi et al, 2021, Placenta CrossRef
  54. Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits
    James Sweet-Jones et al, 2021, Front. Genet. CrossRef
  55. Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations
    Elek Gergő Kovács et al, 2021, Nutrients CrossRef
  56. Cyclic nucleotide phosphodiesterase inhibition as a potential therapeutic target in renal ischemia reperfusion injury
    Komal Thapa et al, 2021, Life Sciences CrossRef
  57. Systematically assessing genetic strategies for engineering electroactive bacterium to promote bioelectrochemical performances and pollutant removal
    Feng-He Li et al, 2021, Sustainable Energy Technologies and Assessments CrossRef
  58. In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity
    Marieke Esther Hoonakker, 2021, Toxins CrossRef
  59. miR-5701 promoted apoptosis of clear cell renal cell carcinoma cells by targeting phosphodiesterase-1B
    Changan Zhao et al, 2021 CrossRef
  60. An insight into crosstalk among multiple signaling pathways contributing to epileptogenesis
    Vipasha Gautam et al, 2021, European Journal of Pharmacology CrossRef
  61. Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy
    Elisa Saccon et al, 2021, Microbiol Spectr CrossRef
  62. The Role of cAMP-PKA Pathway in Lactate-Induced Intramuscular Triglyceride Accumulation and Mitochondria Content Increase in Mice
    Siyu Chen et al, 2021, Front. Physiol. CrossRef
  63. G protein-coupled estrogen receptor signaling dependent epidermal growth-like factor expression is required for NPR2 inhibition and meiotic resumption in goat oocytes
    Sihai Lu et al, 2021, Theriogenology CrossRef
  64. Hierarchy and control of ageing-related methylation networks
    Gergely Palla et al, 2021, PLoS Comput Biol CrossRef
  65. The Involvement of PDE4 in the Protective Effects of Melatonin on Cigarette-Smoke-Induced Chronic Obstructive Pulmonary Disease
    Je-Oh Lim et al, 2021, Molecules CrossRef
  66. Prostaglandin-associated periorbitopathy syndrome (PAPS): Addressing an unmet clinical need
    Rei Sakata et al, 2021, Seminars in Ophthalmology CrossRef
  67. Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance
    Sahaya Nadar et al, 2022, Microorganisms CrossRef
  68. Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer’s Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-κB/BACE-1 Mediated Aβ Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway
    Noorul Hasan et al, 2022, Neurotox Res CrossRef
  69. Wolfram Syndrome 1: From Genetics to Therapy
    Luciana Rigoli et al, 2022, IJERPH CrossRef
  70. A multiplexed epitope barcoding strategy that enables dynamic cellular phenotypic screens
    Takamasa Kudo et al, 2022, Cell Systems CrossRef
  71. A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions.
    David Barrett et al, 2022, SLAS Discovery CrossRef
  72. The predominance of endothelium-derived relaxing factors and beta-adrenergic receptor pathways in strong vasorelaxation induced by 4-hydroxybenzaldehyde in the rat aorta
    Yean Chun Loh et al, 2022, Biomedicine & Pharmacotherapy CrossRef
  73. Regulation of the vital activity of cells, tissues and organs in the human body and mechanisms for its implementation (review)
    V. Y. Milyukov et al, 2022, Regional blood circulation and microcirculation CrossRef
  74. The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP
    Wei Yue et al, 2022, Front. Cell Dev. Biol. CrossRef
  75. A multiscale model of the regulation of aquaporin 2 recycling
    Christoph Leberecht et al, 2022, npj Syst Biol Appl CrossRef
  76. The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation
    Hoang Oanh Nguyen et al, 2022, J Transl Med CrossRef
  77. Exploring the role of cAMP in gabapentin- mediated pain attenuating effects in chronic constriction injury model in rats
    Deepankshi Sharma et al, 2022, Braz. J. Pharm. Sci. CrossRef
  78. Development of a Liquid Chromatography–Mass Spectrometry-Based In Vitro Assay to Assess Changes in Steroid Hormones Due to Exposure to Per- and Polyfluoroalkyl Substances
    Logan Running et al, 2022, Chem. Res. Toxicol. CrossRef
  79. Mechanistic insights on cytotoxicity of KOLR , Cinnamomum pauciflorum Nees leaf derived active ingredient, by targeting signaling complexes of phosphodiesterase 3B and rap guanine nucleotide exchange factor 3
    Mingqian Li et al, 2022, Phytotherapy Research CrossRef
  80. Question-driven stepwise experimental discoveries in biochemistry: two case studies
    Michael Fry, 2022, HPLS CrossRef
  81. Single-Dose Induction of Osteogenic Differentiation of Mesenchymal Stem Cells Using a Cyclic AMP Activator, Forskolin
    Guleid M. Awale et al, 2022, Regen. Eng. Transl. Med. CrossRef
  82. Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate
    Adrina Kalasho Kuzmiszyn et al, 2022, Front. Physiol. CrossRef
  83. Human Pluripotent Stem Cell-Derived Alveolar Organoid with Macrophages
    Ha-Rim Seo et al, 2022, IJMS CrossRef
  84. The NO / cGMP / PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders
    Anisa Degjoni et al, 2022, J of Thrombosis Haemost CrossRef
  85. Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
    Ved Mehta et al, 2022 CrossRef
  86. The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment
    Jiachun Lian et al, 2022, Front. Immunol. CrossRef
  87. Inhibition of phosphodiesterase: A novel therapeutic target for the treatment of mild cognitive impairment and Alzheimer’s disease
    Jianwen Sheng et al, 2022, Front. Aging Neurosci. CrossRef
  88. Mitoregulin controls mitochondrial function and stress-adaptation response during early phase of endoplasmic reticulum stress in breast cancer cells
    Munkyung Choi et al, 2022, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease CrossRef
  89. Copper-Dependent Kinases and Their Role in Cancer Inception, Progression and Metastasis
    Alessandra Vitaliti et al, 2022, Biomolecules CrossRef
  90. Prostaglandin-Associated Periorbitopathy Symptom Alleviation After Switching Prostaglandin F Receptor Agonist to EP2 Receptor Agonist in Patients with Glaucoma
    Rei Sakata et al, 2022, Journal of Ocular Pharmacology and Therapeutics CrossRef
  91. A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers
    Thoraia Shinawi et al, 2022, Front. Genet. CrossRef
  92. Cyclic Adenosine Monophosphate: A Central Player in Gamete Development and Fertilization, and Possible Target for Infertility Therapies
    Jan Tesarik et al, 2022, IJMS CrossRef
  93. Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets
    Rabia Akram et al, 2022, Biomedicines CrossRef
  94. Moderate but not severe hypothermia increases intracellular cyclic AMP through preserved production and reduced elimination
    Adrina Kalasho Kuzmiszyn et al, 2023, Cryobiology CrossRef
  95. p-CREB and p-DARPP-32 orchestrating the modulatory role of cAMP/PKA signaling pathway enhanced by Roflumilast in rotenone-induced Parkinson's disease in rats
    Reham M. Essam et al, 2023, Chemico-Biological Interactions CrossRef
  96. Gamma-aminobutyric acid (GABA) suppresses hemocyte phagocytosis by binding to GABA receptors and modulating corresponding downstream pathways in blood clam, Tegillarca granosa
    Yihan Yu et al, 2023, Fish & Shellfish Immunology CrossRef
  97. The role of polyunsaturated fatty acids in neuronal signaling in depression and cognitive processes
    K. Stachowicz, 2023, Archives of Biochemistry and Biophysics CrossRef
  98. The ATP-dependent Pathways and Human Diseases
    Justyna Suwara et al, 2023, CMC CrossRef
  99. Cutaneous transcriptomic profiling and candidate pigment genes in the wild discus (Symphysodon spp.)
    Tian Tsyh Ng et al, 2023, New Zealand Journal of Zoology CrossRef
  100. Epac as a tractable therapeutic target
    Hasan Slika et al, 2023, European Journal of Pharmacology CrossRef
  101. Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice
    Sungsu Lim et al, 2023, Exp Mol Med CrossRef
  102. Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth
    Irene Ramos-Alvarez et al, 2023, Front. Physiol. CrossRef
  103. Role of the adenylate cyclase/cyclic AMP pathway in oxytocin-induced lacrimal gland myoepithelial cells contraction
    Angela Gárriz et al, 2023, Experimental Eye Research CrossRef
  104. Midazolam nanocrystal facilitates submandibular lymphatic metabolism via cAMP signal transduction pathway
    Qun Cheng et al, 2023, mat express CrossRef
  105. Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth
    Mi-Hyeon Jeong et al, 2023 CrossRef
  106. Weighted single-step genome-wide association study and functional enrichment analyses for gastrointestinal nematode resistance traits in Santa Ines sheep
    Nedenia Bonvino Stafuzza et al, 2023, Veterinary Parasitology CrossRef
  107. Potential PDE4B inhibitors as promising candidates against SARS‐CoV‐2 infection
    Federica Giuzio et al, 2023 CrossRef
  108. Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide
    Zala Slabe et al, 2023, Front. Mol. Neurosci. CrossRef
  109. A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset
    Petra Daďová et al, 2023, International Immunopharmacology CrossRef
  110. Mechanism-based biomarkers for the quality control of Dangkwisoo-san: a scoping review
    Ji Hwan Lee et al, 2023, Appl Biol Chem CrossRef
  111. The Role of Various Factors in Neural Differentiation of Human Umbilical Cord Mesenchymal Stem Cells with a Special Focus on the Physical Stimulants
    Sajad Seyyedin et al, 2024, CSCR CrossRef
  112. Host cell cAMP-Epac-Rap1b pathway inhibition by hawthorn extract as a potential target against Trypanosoma cruzi infection
    Gabriel Ferri et al, 2023, Front. Microbiol. CrossRef
  113. Difamilast: PDE4 Inhibitor Ointment
    Kenta Horimukai, 2023, Jpn.J.Pediatr.Allergy Clin.Immunol CrossRef
  114. Metabolomics-transcriptomics joint analysis: unveiling the dysregulated cell death network and developing a diagnostic model for high-grade neuroblastoma
    Wancun Zhang et al, 2024, Front. Immunol. CrossRef
  115. Forskolin rescues hypoxia-induced cognitive dysfunction in zebrafish with potential involvement of O-GlcNAc cycling regulation
    Quynh T.N. Nguyen et al, 2024, Biochemical Pharmacology CrossRef
  116. MIWE: detecting the critical states of complex biological systems by the mutual information weighted entropy
    Yuke Xie et al, 2024, BMC Bioinformatics CrossRef
  117. Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy
    Jianying Li et al, 2024, Cancer Immunol Immunother CrossRef
  118. Generic model to unravel the deeper insights of viral infections: an empirical application of evolutionary graph coloring in computational network biology
    Arnab Kole et al, 2024, BMC Bioinformatics CrossRef
  119. Regenerative engineering of long bones using the small molecule forskolin
    Guleid M. Awale et al, 2023, Proc. Natl. Acad. Sci. U.S.A. CrossRef
  120. Biotechnological interventions for the production of forskolin, an active compound from the medicinal plant, Coleus forskohlii
    Pulukkunadu Thekkeveedu Roshni et al, 2024, Physiol Mol Biol Plants CrossRef
  121. null
    Ahmet Ozan Ozgen et al, 2023 CrossRef
  122. Biochemical pharmacology of adenylyl cyclases in cancer
    Bikash Chandra Jena et al, 2024, Biochemical Pharmacology CrossRef
  123. Phosphodiesterase Inhibitors of Natural Origin
    Rui Han et al, 2024, NPJ CrossRef
  124. Enhancing PKA-dependent mesothelial barrier integrity reduces ovarian cancer transmesothelial migration via inhibition of contractility
    Dorota E. Jazwinska et al, 2024, iScience CrossRef
  125. Stromal cell decidualization and embryo implantation: a vulnerable step leading to successful pregnancy
    Luhan Jiang et al, 2024 CrossRef
  126. Bioinformatics analyses and experimental validation of ferroptosis-related genes in bronchopulmonary dysplasia pathogenesis
    Yifan Luo et al, 2024, PLoS ONE CrossRef
  127. Beyond PDE4 inhibition: A comprehensive review on downstream cAMP signaling in the central nervous system
    Zoë Donders et al, 2024, Biomedicine & Pharmacotherapy CrossRef
  128. Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes
    Eijiro Sakamoto et al, 2024, Cell Reports CrossRef