- Biologic activity of cyclic and caged phosphates: a review
Dietrich E. Lorke et al, 2017, J. Appl. Toxicol. CrossRef - Synthesis and antiproliferative evaluation of novel azido nucleosides and their phosphoramidate derivatives
Nuno M. Xavier et al, 2017 CrossRef - Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice
Hongfang Feng et al, 2017, Lab Invest CrossRef - The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
Teresinha Regina Ribeiro de Oliveira et al, 2017, Acta Cir. Bras. CrossRef - Differential detection and quantification of cyclic AMP and other adenosine phosphates in live cells
Sujoy Das et al, 2017, Chem. Commun. CrossRef - Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment
Naveen Kumar et al, 2018, Mol Cell Biochem CrossRef - null
Filomena S. G. Silva et al, 2018 CrossRef - Dual-Functionalized Calcium Nanocomplexes for Transfection of Cancerous and Stem Cells: Low Molecular Weight Polycation-mediated Colloidal Stability and ATP-mediated Endosomal Release
Yeon Su Choi et al, 2018, Journal of Industrial and Engineering Chemistry CrossRef - Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system
Jane A Mitchell et al, 2018, British Journal of Pharmacology CrossRef - “Riddle Me This”: Substrate Channeling Solves the Paradigms of cAMP-Dependent Activation of PKA
César A. Ramírez-Sarmiento, 2017, Biophysical Journal CrossRef - cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer
Naveen Kumar et al, 2018 CrossRef - Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain
Grażyna Chłoń-Rzepa et al, 2018, European Journal of Medicinal Chemistry CrossRef - null
Walter Gottlieb Land, 2018 CrossRef - The Arabidopsis thaliana K+-Uptake Permease 5 (AtKUP5) Contains a Functional Cytosolic Adenylate Cyclase Essential for K+ Transport
Inas Al-Younis et al, 2018, Front. Plant Sci. CrossRef - The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
Irina V. Tcymbarevich et al, 2019, BMC Gastroenterol CrossRef - Cyclic AMP-dependent protein kinase A and EPAC mediate VIP and secretin stimulation of PAK4 and activation of Na+,K+-ATPase in pancreatic acinar cells
Irene Ramos-Alvarez et al, 2019, American Journal of Physiology-Gastrointestinal and Liver Physiology CrossRef - IPP-1 controls Akt/CREB phosphorylation extension in A2a adenosine receptor signaling cascade in MIN6 Pancreatic β-cell line
Mohammad Keyvanloo Shahrestanaki et al, 2019, European Journal of Pharmacology CrossRef - cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis
Ruochan Chen et al, 2019, Sci. Adv. CrossRef - null
Eliza Oprea et al, 2019 CrossRef - Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
Selena Vigano et al, 2019, Front. Immunol. CrossRef - Transforming Growth Factor-β1 Decreases β2-Agonist–induced Relaxation in Human Airway Smooth Muscle
Christie A. Ojiaku et al, 2019, Am J Respir Cell Mol Biol CrossRef - Plant Probiotic Bacterial Endophyte, Alcaligenes faecalis, Modulates Plant Growth and Forskolin Biosynthesis in Coleus forskohlii
Anthati Mastan et al, 2019, Probiotics & Antimicro. Prot. CrossRef - Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention
Víctor M. Muñoz-Pérez et al, 2019, CPB CrossRef - Cardiac function modulation depends on the A‐kinase anchoring protein complex
Yan‐Rong Zhu et al, 2019, J Cell Mol Med CrossRef - null
Nuno M Xavier, 2017 CrossRef - Transcriptomic profiling of gamma ray induced mutants from the CGL1 human hybrid cell system reveals novel insights into the mechanisms of radiation-induced carcinogenesis
Jake Pirkkanen et al, 2019, Free Radical Biology and Medicine CrossRef - null
Michael J. McPherson et al, 2020 CrossRef - Cyclic nucleotides and myometrial contractility
Damian D Guerra et al, 2020, Current Opinion in Physiology CrossRef - Physical exercise and catecholamines response: benefits and health risk: possible mechanisms
Joanna Kruk et al, 2020, Free Radical Research CrossRef - Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis
Sonu Kashyap et al, 2020 CrossRef - Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update
Meenu Mehta et al, 2020, Inflammopharmacol CrossRef - Progesterone/Org inhibits lung adenocarcinoma cell growth via membrane progesterone receptor alpha
Jian Xiao et al, 2020, Thorac Cancer CrossRef - Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome
Lien D. Nguyen et al, 2020, Proc Natl Acad Sci USA CrossRef - Stability of regulatory T cells in T helper 2–biased allergic airway diseases
Feng Lan et al, 2020, Allergy CrossRef - Genome‐wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology
Kwangsik Nho et al, 2020, Alzheimer's & Dementia CrossRef - The immunomodulatory role of PDEs inhibitors in immune cells: therapeutic implication in rheumatoid arthritis
YuFei He et al, 2020, Pharmacological Research CrossRef - Chemical Biology Toolbox for Studying Pancreatic Islet Function – A Perspective
Julia Huey et al, 2020, Cell Chemical Biology CrossRef - Role of Akt signaling pathway regulation in the speckled mousebird (Colius striatus) during torpor displays tissue specific responses
StuartR. Green et al, 2020, Cellular Signalling CrossRef - Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis
Suzanne E. Eldridge et al, 2020, Sci. Transl. Med. CrossRef - Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey
Alireza Tafazoli et al, 2021, JCM CrossRef - ADeditome provides the genomic landscape of A-to-I RNA editing in Alzheimer’s disease
Sijia Wu et al, 2021 CrossRef - Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis
Mark J. Turner et al, 2021, Pharmacology & Therapeutics CrossRef - Dual Inhibition of Ornithine Decarboxylase and A1 Adenosine Receptor Efficiently Suppresses Breast Tumor Cells
Hongyan Ma et al, 2021, Front. Oncol. CrossRef - Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling
Basel A. Abdel-Wahab et al, 2021, Food and Chemical Toxicology CrossRef - Changes in metabolite concentrations in the abdominal muscle of the kuruma shrimp Marsupenaeus japonicus in response to different salinities
Hiroki Koyama et al, 2021, Fish Sci CrossRef - Roflumilast as a Potential Therapeutic Agent for Cecal Ligation and Puncture-Induced Septic Lung Injury
Zafer Bayraktutan et al, 2021, Journal of Investigative Surgery CrossRef - Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19
Ki Kwang Oh et al, 2021, Sci Rep CrossRef - Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation
Ian M. Cartwright et al, 2021, Proc Natl Acad Sci USA CrossRef - Modulation of Cyclic AMP Levels in Fallopian Tube Cells by Natural and Environmental Estrogens
Marinella Rosselli et al, 2021, Cells CrossRef - Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis.
Shuo Yu et al, 2021, Mol Metab CrossRef - Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases
Qiangqiang Zheng et al, 2021 CrossRef -
The Small Molecule H89 Inhibits
Chlamydia
Inclusion Growth and Production of Infectious Progeny
Karissa J. Muñoz et al, 2021, Infect Immun CrossRef - Iodothyronine deiodinase 2 (DiO2) regulates trophoblast cell line cycle, invasion and apoptosis; and its downregulation is associated with early recurrent miscarriage
Enoch Appiah Adu-Gyamfi et al, 2021, Placenta CrossRef - Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits
James Sweet-Jones et al, 2021, Front. Genet. CrossRef - Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations
Elek Gergő Kovács et al, 2021, Nutrients CrossRef - Cyclic nucleotide phosphodiesterase inhibition as a potential therapeutic target in renal ischemia reperfusion injury
Komal Thapa et al, 2021, Life Sciences CrossRef - Systematically assessing genetic strategies for engineering electroactive bacterium to promote bioelectrochemical performances and pollutant removal
Feng-He Li et al, 2021, Sustainable Energy Technologies and Assessments CrossRef - In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity
Marieke Esther Hoonakker, 2021, Toxins CrossRef - miR-5701 promoted apoptosis of clear cell renal cell carcinoma cells by targeting phosphodiesterase-1B
Changan Zhao et al, 2021 CrossRef - An insight into crosstalk among multiple signaling pathways contributing to epileptogenesis
Vipasha Gautam et al, 2021, European Journal of Pharmacology CrossRef - Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy
Elisa Saccon et al, 2021, Microbiol Spectr CrossRef - The Role of cAMP-PKA Pathway in Lactate-Induced Intramuscular Triglyceride Accumulation and Mitochondria Content Increase in Mice
Siyu Chen et al, 2021, Front. Physiol. CrossRef - G protein-coupled estrogen receptor signaling dependent epidermal growth-like factor expression is required for NPR2 inhibition and meiotic resumption in goat oocytes
Sihai Lu et al, 2021, Theriogenology CrossRef - Hierarchy and control of ageing-related methylation networks
Gergely Palla et al, 2021, PLoS Comput Biol CrossRef - The Involvement of PDE4 in the Protective Effects of Melatonin on Cigarette-Smoke-Induced Chronic Obstructive Pulmonary Disease
Je-Oh Lim et al, 2021, Molecules CrossRef - Prostaglandin-associated periorbitopathy syndrome (PAPS): Addressing an unmet clinical need
Rei Sakata et al, 2021, Seminars in Ophthalmology CrossRef - Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance
Sahaya Nadar et al, 2022, Microorganisms CrossRef - Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer’s Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-κB/BACE-1 Mediated Aβ Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway
Noorul Hasan et al, 2022, Neurotox Res CrossRef - Wolfram Syndrome 1: From Genetics to Therapy
Luciana Rigoli et al, 2022, IJERPH CrossRef - A multiplexed epitope barcoding strategy that enables dynamic cellular phenotypic screens
Takamasa Kudo et al, 2022, Cell Systems CrossRef - A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions.
David Barrett et al, 2022, SLAS Discovery CrossRef - The predominance of endothelium-derived relaxing factors and beta-adrenergic receptor pathways in strong vasorelaxation induced by 4-hydroxybenzaldehyde in the rat aorta
Yean Chun Loh et al, 2022, Biomedicine & Pharmacotherapy CrossRef - Regulation of the vital activity of cells, tissues and organs in the human body and mechanisms for its implementation (review)
V. Y. Milyukov et al, 2022, Regional blood circulation and microcirculation CrossRef - The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP
Wei Yue et al, 2022, Front. Cell Dev. Biol. CrossRef - A multiscale model of the regulation of aquaporin 2 recycling
Christoph Leberecht et al, 2022, npj Syst Biol Appl CrossRef - The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation
Hoang Oanh Nguyen et al, 2022, J Transl Med CrossRef - Exploring the role of cAMP in gabapentin- mediated pain attenuating effects in chronic constriction injury model in rats
Deepankshi Sharma et al, 2022, Braz. J. Pharm. Sci. CrossRef - Development of a Liquid Chromatography–Mass Spectrometry-Based In Vitro Assay to Assess Changes in Steroid Hormones Due to Exposure to Per- and Polyfluoroalkyl Substances
Logan Running et al, 2022, Chem. Res. Toxicol. CrossRef -
Mechanistic insights on cytotoxicity of
KOLR
, Cinnamomum pauciflorum Nees leaf derived active ingredient, by targeting signaling complexes of phosphodiesterase
3B
and rap guanine nucleotide exchange factor 3
Mingqian Li et al, 2022, Phytotherapy Research CrossRef - Question-driven stepwise experimental discoveries in biochemistry: two case studies
Michael Fry, 2022, HPLS CrossRef - Single-Dose Induction of Osteogenic Differentiation of Mesenchymal Stem Cells Using a Cyclic AMP Activator, Forskolin
Guleid M. Awale et al, 2022, Regen. Eng. Transl. Med. CrossRef - Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate
Adrina Kalasho Kuzmiszyn et al, 2022, Front. Physiol. CrossRef - Human Pluripotent Stem Cell-Derived Alveolar Organoid with Macrophages
Ha-Rim Seo et al, 2022, IJMS CrossRef -
The
NO
/
cGMP
/
PKG
pathway in platelets: The therapeutic potential of
PDE5
inhibitors in platelet disorders
Anisa Degjoni et al, 2022, J of Thrombosis Haemost CrossRef - Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
Ved Mehta et al, 2022 CrossRef - The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment
Jiachun Lian et al, 2022, Front. Immunol. CrossRef - Inhibition of phosphodiesterase: A novel therapeutic target for the treatment of mild cognitive impairment and Alzheimer’s disease
Jianwen Sheng et al, 2022, Front. Aging Neurosci. CrossRef - Mitoregulin controls mitochondrial function and stress-adaptation response during early phase of endoplasmic reticulum stress in breast cancer cells
Munkyung Choi et al, 2022, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease CrossRef - Copper-Dependent Kinases and Their Role in Cancer Inception, Progression and Metastasis
Alessandra Vitaliti et al, 2022, Biomolecules CrossRef - Prostaglandin-Associated Periorbitopathy Symptom Alleviation After Switching Prostaglandin F Receptor Agonist to EP2 Receptor Agonist in Patients with Glaucoma
Rei Sakata et al, 2022, Journal of Ocular Pharmacology and Therapeutics CrossRef - A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers
Thoraia Shinawi et al, 2022, Front. Genet. CrossRef - Cyclic Adenosine Monophosphate: A Central Player in Gamete Development and Fertilization, and Possible Target for Infertility Therapies
Jan Tesarik et al, 2022, IJMS CrossRef - Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets
Rabia Akram et al, 2022, Biomedicines CrossRef - Moderate but not severe hypothermia increases intracellular cyclic AMP through preserved production and reduced elimination
Adrina Kalasho Kuzmiszyn et al, 2023, Cryobiology CrossRef - p-CREB and p-DARPP-32 orchestrating the modulatory role of cAMP/PKA signaling pathway enhanced by Roflumilast in rotenone-induced Parkinson's disease in rats
Reham M. Essam et al, 2023, Chemico-Biological Interactions CrossRef - Gamma-aminobutyric acid (GABA) suppresses hemocyte phagocytosis by binding to GABA receptors and modulating corresponding downstream pathways in blood clam, Tegillarca granosa
Yihan Yu et al, 2023, Fish & Shellfish Immunology CrossRef - The role of polyunsaturated fatty acids in neuronal signaling in depression and cognitive processes
K. Stachowicz, 2023, Archives of Biochemistry and Biophysics CrossRef - The ATP-dependent Pathways and Human Diseases
Justyna Suwara et al, 2023, CMC CrossRef - Cutaneous transcriptomic profiling and candidate pigment genes in the wild discus (Symphysodon spp.)
Tian Tsyh Ng et al, 2023, New Zealand Journal of Zoology CrossRef - Epac as a tractable therapeutic target
Hasan Slika et al, 2023, European Journal of Pharmacology CrossRef - Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice
Sungsu Lim et al, 2023, Exp Mol Med CrossRef - Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth
Irene Ramos-Alvarez et al, 2023, Front. Physiol. CrossRef - Role of the adenylate cyclase/cyclic AMP pathway in oxytocin-induced lacrimal gland myoepithelial cells contraction
Angela Gárriz et al, 2023, Experimental Eye Research CrossRef - Midazolam nanocrystal facilitates submandibular lymphatic metabolism via cAMP signal transduction pathway
Qun Cheng et al, 2023, mat express CrossRef - Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth
Mi-Hyeon Jeong et al, 2023 CrossRef - Weighted single-step genome-wide association study and functional enrichment analyses for gastrointestinal nematode resistance traits in Santa Ines sheep
Nedenia Bonvino Stafuzza et al, 2023, Veterinary Parasitology CrossRef - Potential PDE4B inhibitors as promising candidates against SARS‐CoV‐2 infection
Federica Giuzio et al, 2023 CrossRef - Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide
Zala Slabe et al, 2023, Front. Mol. Neurosci. CrossRef - A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset
Petra Daďová et al, 2023, International Immunopharmacology CrossRef - Mechanism-based biomarkers for the quality control of Dangkwisoo-san: a scoping review
Ji Hwan Lee et al, 2023, Appl Biol Chem CrossRef - The Role of Various Factors in Neural Differentiation of Human Umbilical
Cord Mesenchymal Stem Cells with a Special Focus on the Physical Stimulants
Sajad Seyyedin et al, 2024, CSCR CrossRef - Host cell cAMP-Epac-Rap1b pathway inhibition by hawthorn extract as a potential target against Trypanosoma cruzi infection
Gabriel Ferri et al, 2023, Front. Microbiol. CrossRef - Difamilast: PDE4 Inhibitor Ointment
Kenta Horimukai, 2023, Jpn.J.Pediatr.Allergy Clin.Immunol CrossRef - Metabolomics-transcriptomics joint analysis: unveiling the dysregulated cell death network and developing a diagnostic model for high-grade neuroblastoma
Wancun Zhang et al, 2024, Front. Immunol. CrossRef - Forskolin rescues hypoxia-induced cognitive dysfunction in zebrafish with potential involvement of O-GlcNAc cycling regulation
Quynh T.N. Nguyen et al, 2024, Biochemical Pharmacology CrossRef - MIWE: detecting the critical states of complex biological systems by the mutual information weighted entropy
Yuke Xie et al, 2024, BMC Bioinformatics CrossRef - Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy
Jianying Li et al, 2024, Cancer Immunol Immunother CrossRef - Generic model to unravel the deeper insights of viral infections: an empirical application of evolutionary graph coloring in computational network biology
Arnab Kole et al, 2024, BMC Bioinformatics CrossRef - Regenerative engineering of long bones using the small molecule forskolin
Guleid M. Awale et al, 2023, Proc. Natl. Acad. Sci. U.S.A. CrossRef - Biotechnological interventions for the production of forskolin, an active compound from the medicinal plant, Coleus forskohlii
Pulukkunadu Thekkeveedu Roshni et al, 2024, Physiol Mol Biol Plants CrossRef - null
Ahmet Ozan Ozgen et al, 2023 CrossRef - Biochemical pharmacology of adenylyl cyclases in cancer
Bikash Chandra Jena et al, 2024, Biochemical Pharmacology CrossRef - Phosphodiesterase Inhibitors of Natural Origin
Rui Han et al, 2024, NPJ CrossRef - Enhancing PKA-dependent mesothelial barrier integrity reduces ovarian cancer transmesothelial migration via inhibition of contractility
Dorota E. Jazwinska et al, 2024, iScience CrossRef - Stromal cell decidualization and embryo implantation: a vulnerable step leading to successful pregnancy
Luhan Jiang et al, 2024 CrossRef - Bioinformatics analyses and experimental validation of ferroptosis-related genes in bronchopulmonary dysplasia pathogenesis
Yifan Luo et al, 2024, PLoS ONE CrossRef - Beyond PDE4 inhibition: A comprehensive review on downstream cAMP signaling in the central nervous system
Zoë Donders et al, 2024, Biomedicine & Pharmacotherapy CrossRef - Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes
Eijiro Sakamoto et al, 2024, Cell Reports CrossRef