1. Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5′-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form
   Ming Yan et al, 2016, Biochemistry CrossRef
2. Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress
   Xuefeng Wu et al, 2017, BioMed Research International CrossRef
3. Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy
   Ana Cavaco et al, 2017, IJMS CrossRef
4. IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer
   Yi-Yang Wen et al, 2017, Sci Rep CrossRef
5. Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2
   Dhiraj Srivastava et al, 2017, Biochemistry CrossRef
6. Oncogene-Driven Metabolic Alterations in Cancer
   Hye-Young Min et al, 2018, Biomolecules & Therapeutics CrossRef
7. FFJ-3 inhibits PKM2 protein expression via the PI3K/Akt signaling pathway and activates the mitochondrial apoptosis signaling pathway in human cancer cells
   Dengyun Li et al, 2017 CrossRef
8. Pulmonary Hypertension Associated With Scleroderma and Connective Tissue Disease: Potential Molecular and Cellular Targets
   Maria Trojanowska, 2017, Advances in Pulmonary Hypertension CrossRef
9. Metabolic phenotyping of CHO cells varying in cellular biomass accumulation and maintenance during fed-batch culture
   Alejandro Fernandez-Martell et al, 2018, Biotechnol. Bioeng. CrossRef
10. AKT2 contributes to increase ovarian cancer cell migration and invasion through the AKT2-PKM2-STAT3/NF-κB axis
    Bin Zheng et al, 2018, Cellular Signalling CrossRef
11. GLP2 Promotes Directed Differentiation from Osteosarcoma Cells to Osteoblasts and Inhibits Growth of Osteosarcoma Cells
    Yi Lu et al, 2018, Molecular Therapy - Nucleic Acids CrossRef
12. Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN
    Qidi Zheng et al, 2018, Cell Death Dis CrossRef
13. Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling.
    Ming-Chuan Hsu et al, 2018, Mol Cancer CrossRef
14. Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia
    Jun-Ho Cho et al, 2018, Biochemical and Biophysical Research Communications CrossRef
15. Metabolic Reprogramming in Thyroid Carcinoma
    Raquel Guimaraes Coelho et al, 2018, Front. Oncol. CrossRef
16. The Warburg Effect in Diabetic Kidney Disease
    Guanshi Zhang et al, 2018, Seminars in Nephrology CrossRef
17. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways
    Marteinn T Snaebjornsson et al, 2018, Exp Mol Med CrossRef
18. The Warburg effect and glucose-derived cancer theranostics
    Rakesh K. Tekade et al, 2017, Drug Discovery Today CrossRef
19. Including the mitochondrial metabolism of l-lactate in cancer metabolic reprogramming
    Lidia de Bari et al, 2018, Cell. Mol. Life Sci. CrossRef
20. Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy.
    Mohammad Hassan Baig et al, 2019, Semin Cancer Biol CrossRef
21. Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice
    Dongdong Chen et al, 2018, Neurotherapeutics CrossRef
22. A Novel Multiple-Read Screen for Metabolically Active Compounds Based on a Genetically Encoded FRET Sensor for ATP
    Ziyan Zhao et al, 2018, SLAS DISCOVERY: Advancing Life Sciences R&D CrossRef
23. Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer
    Bo-wen Liu et al, 2018, Acta Pharmacol Sin CrossRef
24. Hidden features: exploring the non-canonical functions of metabolic enzymes
    Peiwei Huangyang et al, 2018, Dis. Model. Mech. CrossRef
25. Constitutive androstane receptor activation evokes the expression of glycolytic genes
    Andrei A. Yarushkin et al, 2016, Biochemical and Biophysical Research Communications CrossRef
26. Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
    Angelo D'Alessandro et al, 2018, Antioxidants & Redox Signaling CrossRef
27. Emerging roles of Myc in stem cell biology and novel tumor therapies.
    Go J Yoshida, 2018, J Exp Clin Cancer Res CrossRef
28. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension
    Cheng-Jun Hu et al, 2018, J Physiol CrossRef
29. In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity
    Ravi K. Sajja et al, 2018, Sci Rep CrossRef
30. Environmentally relevant concentrations of carbamazepine induce liver histopathological changes and a gender-specific response in hepatic proteome of Chinese rare minnows (Gobiocypris rarus)
    Saihong Yan et al, 2018, Environmental Pollution CrossRef
31. An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade
    Serena Fortunato et al, 2018, ChemMedChem CrossRef
32. Colorectal Cancer and Metabolism
    Rachel E. Brown et al, 2018, Curr Colorectal Cancer Rep CrossRef
33. Identification of Protein Abundance Changes in Hepatocellular Carcinoma Tissues Using PCT-SWATH
    Yi Zhu et al, 2018, Prot. Clin. Appl. CrossRef
34. miR-625-5p/PKM2 negatively regulates melanoma glycolysis state
    Hailin Zhang et al, 2018, J Cell Biochem CrossRef
35. The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation
    Simranjit Singh et al, 2018, Sci Rep CrossRef
36. Human asparagine synthetase associates with the mitotic spindle
    Chalongrat Noree et al, 2018, Biology Open CrossRef
37. Non-canonical localization of PKM2 in cancer progression: Mechanism of nuclear translocation
    Sajid Amin et al, 2019, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
38. Overexpression of Pyruvate Kinase M2 in Tumor Tissues Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
    Rui Zhao et al, 2019, Pathol. Oncol. Res. CrossRef
39. Tumorigenesis and Metabolism Disorder
    Fan Yang et al, 2019 CrossRef
40. Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism
    Li Zhang et al, 2019, IJMS CrossRef
41. A New Compound-ensemble Strategy for Validating Cancer Drug Targets Confirms that Inhibiting Glycolysis Blocks Leukemic Cell Proliferation.
    Ziyan Zhao et al, 2018, SSRN Journal CrossRef
42. Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer
    Yanhong Pan et al, 2019, Front. Pharmacol. CrossRef
43. Evolutionary engineering of Corynebacterium glutamicum
    Roberto G. Stella et al, 2019, Biotechnol. J. CrossRef
44. Enhanced penetration and cytotoxicity of metformin and collagenase conjugated gold nanoparticles in breast cancer spheroids
    Elaheh Dalir Abdolahinia et al, 2019, Life Sciences CrossRef
45. Salivary Diagnostics in Oral Diseases
    Manohar Bhat et al, 2019 CrossRef
46. PKM2, function and expression and regulation
    Ze Zhang et al, 2019, Cell Biosci CrossRef
47. FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis.
    Alex Cordero et al, 2019, Oncogene CrossRef
48. Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
    Yanhong Pan et al, 2019, J Cell Mol Med CrossRef
49. Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism
    Yannick Audet-Delage et al, 2017, Mol Pharmacol CrossRef
50. Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2
    Dhiraj Srivastava et al, 2019, Biochemistry CrossRef
51. Metabolic Plasticity of Acute Myeloid Leukemia
    null Kreitz et al, 2019, Cells CrossRef
52. Redox rebalance against genetic perturbations and modulation of central carbon metabolism by the oxidative stress regulation
    Kazuyuki Shimizu et al, 2019, Biotechnology Advances CrossRef
53. Gene expression association study in feline mammary carcinomas
    Daniela Ferreira et al, 2019, PLoS ONE CrossRef
54. A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases
    Hyong Woo Choi et al, 2019, Sci Rep CrossRef
55. Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism
    null Marrocco et al, 2019, Cells CrossRef
56. Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2
    Hong Zhang et al, 2017 CrossRef
57. Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism
    Waqar Arif et al, 2017, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms CrossRef
58. Residual pyruvate kinase activity inPKLR-deficient erythroid precursors of a patient suffering from severe haemolytic anaemia
    Thomas R.L. Klei et al, 2017, Eur J Haematol CrossRef
59. Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis
    Jinlu Dai et al, 2019, J. Exp. Med. CrossRef
60. Pyruvate kinase M2 interacts with mammalian sterile 20-like kinase 1 and inhibits tamoxifen-induced apoptosis in human breast cancer cells
    Feihu Ji et al, 2017, Tumour Biol. CrossRef
61. The hexane fraction of the Moringa oleifera Lam seed extract induces apoptosis, causes cell cycle arrest, and modulates expression of HSP60, NPM, PGK1, RCN1, and PDIA1 in MCF7 cells
    I.A. Adebayo et al, 2019, South African Journal of Botany CrossRef
62. Metabolic crosstalk in the breast cancer microenvironment.
    Ana S Dias et al, 2019, Eur J Cancer CrossRef
63. Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer
    Kanchan Singh et al, 2019, Oncogene CrossRef
64. Nuclear localization of metabolic enzymes in immunity and metastasis
    Yuchen He et al, 2017, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
65. Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension
    Lydie Plecitá-Hlavatá et al, 2017 CrossRef
66. Adaptive laboratory evolution of Corynebacterium glutamicum towards higher growth rates on glucose minimal medium
    Eugen Pfeifer et al, 2017, Sci Rep CrossRef
67. Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer
    Yiming Yang et al, 2017, Medicine CrossRef
68. DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
    Ling Chen et al, 2019, Epigenetics & Chromatin CrossRef
69. New Insights in the IP3 Receptor and Its Regulation
    Jan B. Parys et al, 2020 CrossRef
70. Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells
    Yuko Ito et al, 2019, J Toxicol Pathol CrossRef
71. A robust strategy for proteomic identification of biomarkers of invasive phenotype complexed with extracellular heat shock proteins
    Steven G. Griffiths et al, 2019, Cell Stress and Chaperones CrossRef
72. Glycolysis promotes the progression of pancreatic cancer and reduces cancer cell sensitivity to gemcitabine
    Shangnan Dai et al, 2020, Biomedicine & Pharmacotherapy CrossRef
73. Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer
    Saharnaz Sarlak et al, 2019, Seminars in Cell & Developmental Biology CrossRef
74. Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer
    Sehui Kim et al, 2019, J Exp Clin Cancer Res CrossRef
75. The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism.
    Ting Tao et al, 2019, Biosci Rep CrossRef
76. Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
    Stefano Angiari et al, 2019, Cell Metabolism CrossRef
77. Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling
    Chinmayee D. Bhedi et al, 2019, FASEB j. CrossRef
78. Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively
    Mauro Sola-Penna et al, 2019, Br J Cancer CrossRef
79. Fragment-based drug discovery using cryo-EM
    Michael Saur et al, 2019, Drug Discovery Today CrossRef
80. An update review of deregulated tumor suppressive microRNAs and their contribution in various molecular subtypes of breast cancer
    Narges Dastmalchi et al, 2019, Gene CrossRef
81. Prostate Cancer Energetics and Biosynthesis
    Chenchu Lin et al, 2019 CrossRef
82. OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels
    Chang-Fang Chiu et al, 2020, Biochemical Pharmacology CrossRef
83. SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming
    Yan Li et al, 2020, Appl Biochem Biotechnol CrossRef
84. Metabolic Symbiosis in Chemoresistance: Refocusing the Role of Aerobic Glycolysis.
    Lisi Ma et al, 2020, Front Oncol CrossRef
85. Identification of Parthenolide Dimers as Activators of Pyruvate Ki-nase M2 in Xenograft of Glioblastoma Multiforme in vivo
    Yahui Ding et al, 2020, J. Med. Chem. CrossRef
86. Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
    Jiao Feng et al, 2020, J Exp Clin Cancer Res CrossRef
87. Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension
    Mathews Valuparampil Varghese et al, 2020, JCM CrossRef
88. The influence of photodynamic therapy on the Warburg effect in esophageal cancer cells
    Junqing Gan et al, 2020, Lasers Med Sci CrossRef
89. Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration.
    Ajit Magadum et al, 2020, Circulation CrossRef
90. Alterations in Metabolite-Driven Gene Regulation in Cancer Metabolism
    Saurabh Kumar Jha et al, 2020 CrossRef
91. Key Signaling Pathways Engaged in Cancer Management: Current Update
    Sanjiv Singh et al, 2020, CCTR CrossRef
92. Cancer Glycolytic Dependence as a New Target of Olive Leaf Extract
    Jessica Ruzzolini et al, 2020, Cancers CrossRef
93. Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells
    Marta Mascaraque et al, 2020, Cancers CrossRef
94. Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications
    Wanda Baer-Dubowska et al, 2020, Curr Pharmacol Rep CrossRef
95. Friend turned Foe: A Curious Case of Disrupted Endosymbiotic Homeostasis Promoting the Warburg Effect in Sepsis
    Natesan Vasanthakumar et al, 2020, Medical Hypotheses CrossRef
96. Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)
    D. A. Richardson et al, 2020, Cancer Metab CrossRef
97. Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy
    Michael F. Coleman et al, 2020, Cancers CrossRef
98. PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa
    Ethan Zhang et al, 2020, Mamm Genome CrossRef
99. Extracellular Vesicles isolated from Mesenchymal Stromal Cells Modulate CD4+ T Lymphocytes Toward a Regulatory Profile
    Flavia Franco da Cunha et al, 2020, Cells CrossRef
100. Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms
     Raju V. S. Rajala, 2020, Front. Cell Dev. Biol. CrossRef
101. Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2
     Fumie Tanaka et al, 2018, Oncotarget CrossRef
102. PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose
     Sui Seng Tee et al, 2017, Oncotarget CrossRef
103. Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation
     Qi Yuan et al, 2020, Cell Death Dis CrossRef
104. Chemical simulation of hypoxia in donor cells improves development of somatic cell nuclear transfer‐derived embryos and increases abundance of transcripts related to glycolysis
     Raissa F. Cecil et al, 2020, Mol Reprod Dev CrossRef
105. Adaptive phenotypic switching in breast cancer in response to matrix deprivation
     Ananthalakshmy Sundararaman et al, 2020 CrossRef
106. Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities
     Sejin Oh et al, 2020, Nat Commun CrossRef
107. Long non‑coding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR‑149/PKM2 axis in non‑small‑cell lung cancer
     Ning Lang et al, 2020, Mol Med Report CrossRef
108. Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species
     Misa Yokoyama et al, 2018, Int J Oncol CrossRef
109. PKM2 Expression as Biomarker for Resistance to Oxaliplatin-Based Chemotherapy in Colorectal Cancer
     Maria Sfakianaki et al, 2020, Cancers CrossRef
110. Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
     Marek Samec et al, 2020, EPMA Journal CrossRef
111. Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review
     Yolla Haibe et al, 2020, IJMS CrossRef
112. Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
     Lenka Koklesova et al, 2020, Cancers CrossRef
113. Phosphoproteomic analysis of dengue virus infected U937 cells and identification of pyruvate kinase M2 as a differentially phosphorylated phosphoprotein
     Jeerang Wongtrakul et al, 2020, Sci Rep CrossRef
114. Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses
     Jessica F Walls et al, 2020 CrossRef
115. The emerging role of long noncoding RNAs in normal liver function, disease and malignancy
     Amin Mahpour et al, 2020, JHEP Reports CrossRef
116. Role of tyrosine phosphorylation in modulating cancer cell metabolism
     Maria Letizia Taddei et al, 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
117. Metabolic interventions: A new insight into the cancer immunotherapy
     Tao Yu et al, 2020, Archives of Biochemistry and Biophysics CrossRef
118. Disruption of microRNA-214 during general anaesthesia prevents brain injury and maintains mitochondrial fusion by promoting Mfn2 interaction with Pkm2.
     Tiejun Liu et al, 2020, J Cell Mol Med CrossRef
119. On the Origin of ATP Synthesis in Cancer
     Thomas N. Seyfried et al, 2020, iScience CrossRef
120. Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells
     Joel James et al, 2020, ATVB CrossRef
121. SEMG1/2 augment energy metabolism of tumor cells
     Oleg Shuvalov et al, 2020, Cell Death Dis CrossRef
122. Alterations in the Transcriptional Programs of Myeloma Cells and the Microenvironment during Extramedullary Progression Affect Proliferation and Immune Evasion
     Daeun Ryu et al, 2020, Clin Cancer Res CrossRef
123. Novel Targeting of Transcription and Metabolism in Glioblastoma
     Yu-Ting Su et al, 2018, Clin Cancer Res CrossRef
124. Flavonoids Targeting HIF-1: Implications on Cancer Metabolism.
     Marek Samec et al, 2021, Cancers (Basel) CrossRef
125. Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers
     Xiangyu Li et al, 2021, Cancers CrossRef
126. The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.
     Dexter L Puckett et al, 2021, Int J Mol Sci CrossRef
127. Phytochemicals Block Glucose Utilization and Lipid Synthesis to Counteract Metabolic Reprogramming in Cancer Cells
     Qiong Wu et al, 2021, Applied Sciences CrossRef
128. Therapeutic Status and Available Strategies in Pancreatic Ductal Adenocarcinoma
     Gitika Thakur et al, 2021, Biomedicines CrossRef
129. Identify the effect of As(III) on the structural stability of monomeric PKM2 and its carcinogenicity: A molecular dynamics and QM/MM based approach
     Priyani Paligaspe et al, 2021, Journal of Molecular Structure CrossRef
130. The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis
     Ainhoa Ruiz-Iglesias et al, 2021, Cancers CrossRef
131. The Hallmarks of Flavonoids in Cancer
     Luis Gustavo Saboia Ponte et al, 2021, Molecules CrossRef
132. Role of protein S-Glutathionylation in cancer progression and development of resistance to anti-cancer drugs
     Debojyoti Pal et al, 2021, Archives of Biochemistry and Biophysics CrossRef
133. HnRNPA1 ISOFORM BRING DIVERSITY IN GLIOMA CELL SURVIVAL
     Vidhi Vashistha et al, 2021 CrossRef
134. The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
     Jing‐Zi Wang et al, 2021, Cancer Communications CrossRef
135. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model
     Alessandro Matte et al, 2021 CrossRef
136. Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents
     Bhagyashri Rathod et al, 2021, RSC Med. Chem. CrossRef
137. Reactive Astrocytes: Critical Players in the Development of Chronic Pain
     James Tang et al, 2021, Front. Psychiatry CrossRef
138. Metabolic changes in triple negative breast cancer-focus on aerobic glycolysis.
     J R Dev Arundhathi et al, 2021, Mol Biol Rep CrossRef
139. The effect of autocrine motility factor alone and in combination with methyl jasmonate on liver cancer cell growth
     Nam Ho Jeoung et al, 2021 CrossRef
140. Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?
     Abu Sufiyan Chhipa et al, 2021, Life Sciences CrossRef
141. Phytocompounds Targeting Metabolic Reprogramming in Cancer: An Assessment of Role, Mechanisms, Pathways, and Therapeutic Relevance
     Asifa Khan et al, 2021, J. Agric. Food Chem. CrossRef
142. Carbohydrate metabolism in prostate cancer
     Tomas Koltai et al, 2021 CrossRef
143. Serine hydroxymethyltransferase 2: a novel target for human cancer therapy
     Min Xie et al, 2021, Invest New Drugs CrossRef
144. PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia
     Han Koo et al, 2021, Cancers CrossRef
145. Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo
     Jianxiang Lin et al, 2021, Cell Prolif CrossRef
146. Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
     Zahra Ghanbari Movahed et al, 2019, Biomedicine & Pharmacotherapy CrossRef
147. Extracellular PKM2 facilitates organ-tissue fibrosis progression
     Hongwei Han et al, 2021, iScience CrossRef
148. Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.
     Chen Wang et al, 2021, Cell Death Dis CrossRef
149. Silencing of Pyruvate Kinase M2 via a Metal–Organic Framework Based Theranostic Gene Nanomedicine for Triple-Negative Breast Cancer Therapy
     Siming Huang et al, 2021, ACS Appl. Mater. Interfaces CrossRef
150. A Clinical PET Imaging Tracer ([¹⁸F]DASA-23) to Monitor Pyruvate Kinase M2-Induced Glycolytic Reprogramming in Glioblastoma.
     Corinne Beinat et al, 2021, Clin Cancer Res CrossRef
151. Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation
     Seo Young Kang et al, 2021, Front. Oncol. CrossRef
152. Ketogenic diet and cancer: Fad or fabulous?
     Manpreet S. Mundi et al, 2021, Journal of Parenteral and Enteral Nutrition CrossRef
153. Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis.
     Qun Yu et al, 2022, Immun Inflamm Dis CrossRef
154. Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer
     Roberto Corchado-Cobos et al, 2022, Cancers CrossRef
155. Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes
     Natpaphan Yawut et al, 2022, BMB Rep CrossRef
156. Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation
     Seong-Lae Jo et al, 2022, Nutrients CrossRef
157. The Role of PKM2 in Diabetic Microangiopathy
     Chao Tu et al, 2022, DMSO CrossRef
158. The CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis
     Kathryn E. Luker et al, 2022, Cells CrossRef
159. The RAGE/multiligand axis: a new actor in tumor biology
     Armando Rojas et al, 2022 CrossRef
160. Application Value of TuM2-PK Detection in Gastrointestinal Tumors
     发蓉 刘, 2022, ACM CrossRef
161. The C-Terminal Acidic Tail Modulates the Anticancer Properties of HMGB1
     Chloé Borde et al, 2022, IJMS CrossRef
162. Relationship between metabolic reprogramming and drug resistance in breast cancer
     Linlin Lv et al, 2022, Front. Oncol. CrossRef
163. Proteomic Analysis of Tumor-specific Biomarkers in Colon Cancer
     Yu-An Chien et al, 2022, CP CrossRef
164. TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure
     Maria Areli Lorenzana-Carrillo et al, 2022, Sci. Transl. Med. CrossRef
165. Knowledge-driven design and optimization of potent symmetric anticancer molecules: A case study on PKM2 activators
     Eshika Jaiswal et al, 2022, Computers in Biology and Medicine CrossRef
166. MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation
     Yang Wu et al, 2022, J Exp Clin Cancer Res CrossRef
167. Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
     Lixia Gao et al, 2023, J Exp Clin Cancer Res CrossRef
168. Role of Moonlighting Proteins in Disease: Analyzing the Contribution of Canonical and Moonlighting Functions in Disease Progression
     Mario Huerta et al, 2023, Cells CrossRef
169. PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism
     Hongyan Lin et al, 2023, European Journal of Medicinal Chemistry CrossRef
170. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway
     Jiancheng Lv et al, 2023, J Exp Clin Cancer Res CrossRef
171. Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation
     Mei-Yu Shen et al, 2023, Pharmaceutical Biology CrossRef
172. Role of tumor microenvironment in cancer progression and therapeutic strategy
     Qingjing Wang et al, 2023, Cancer Medicine CrossRef
173. Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension
     Hui Zhang et al, 2023, Vascular Pharmacology CrossRef
174. Applications and prospects of cryo-EM in drug discovery
     Kong-Fu Zhu et al, 2023, Military Med Res CrossRef
175. Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study
     Krzysztof Marciniec et al, 2023, Molecules CrossRef
176. Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling
     Nevraj S Kejiou et al, 2023 CrossRef
177. Anti‐Warburg effect via generation of ROS and inhibition of PKM2 /β‐catenin mediates apoptosis of lambertianic acid in prostate cancer cells
     Ji‐Na Pak et al, 2023, Phytotherapy Research CrossRef
178. The essential molecular requirements for the transformation of normal cells into established cancer cells, with implications for a novel anti‐cancer agent
     Hilmar M. Warenius, 2023, Cancer Reports CrossRef
179. Activation of pyruvate kinase as therapeutic option for rare hemolytic anemias: Shedding new light on an old enzyme
     Myrthe J. van Dijk et al, 2023, Blood Reviews CrossRef
180. Knockdown of pyruvate kinase M2 suppresses bladder cancer progression
     Guang-Cheng Luo et al, 2023 CrossRef
181. Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment
     Yudi Ma et al, 2023, Bioorganic Chemistry CrossRef
182. Glycolysis as key regulatory step in FSH-induced rat Sertoli cell proliferation: Role of the mTORC1 pathway
     Cecilia Lucia Centola et al, 2023, Biochimie CrossRef
183. KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer
     Mücahit Varlı et al, 2023, Cell Biosci CrossRef
184. Cancer
     Timothy David Noakes et al, 2023 CrossRef
185. Antiviral epithelial-macrophage crosstalk permits secondary bacterial infections
     Sidney Lane et al, 2023, mBio CrossRef
186. Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA
     Seyedeh Tayebeh Ahmadpour et al, 2023, IJMS CrossRef
187. Natural antioxidants as inhibitors of pyruvate kinase M2 in Warburg phenotypes
     Flama Monteiro et al, 2023, Journal of Herbal Medicine CrossRef
188. LncRNA SNHG6 role in clinicopathological parameters in cancers
     Khushbukhat Khan et al, 2023, Eur J Med Res CrossRef
189. Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease
     Xiaowen Chen et al, 2023, Translational Research CrossRef
190. Pyruvate Kinase Differentially Alters Metabolic Signatures during Head and Neck Carcinogenesis
     Pei-Chun Huang et al, 2023, IJMS CrossRef
191. Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm?
     Gagan D Flora et al, 2023 CrossRef
192. Dihydroartemisinin enhances the anti-tumour effect of photodynamic therapy by targeting PKM2-mediated glycolysis in oesophageal cancer cell
     Mengru Jin et al, 2024, Journal of Enzyme Inhibition and Medicinal Chemistry CrossRef
193. ALYREF (Aly/REF export factor): A potential biomarker for predicting cancer occurrence and therapeutic efficacy
     Yan Zhao et al, 2023, Life Sciences CrossRef
194. Dietary approaches for exploiting metabolic vulnerabilities in cancer
     Otília Menyhárt et al, 2023, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
195. Combination of Metformin and Laser against Head and Neck Cancer Cells In Vitro
     Ghasem Ebrahimi et al, 2023, TODENTJ CrossRef
196. AKR1C3 silencing inhibits autophagy‐dependent glycolysis in thyroid cancer cells by inactivating ERK signaling
     Ying Gao et al, 2024, Drug Development Research CrossRef
197. Exploring data‐driven chemical SMILES tokenization approaches to identify key protein–ligand binding moieties
     Asu Busra Temizer et al, 2024, Molecular Informatics CrossRef
198. PKM2 is a Novel Osteoporosis-Associated Protein in Chinese
     Qing Xu et al, 2024, Endocrine Research CrossRef
199. Research Progress of New Urine Markers in the Diagnosis of Bladder Cancer
     Rose Lamichhane, 2024, ann urol oncol CrossRef
200. Exploring the diverse role of pyruvate kinase M2 in cancer: Navigating beyond glycolysis and the Warburg effect
     Saurabh Upadhyay et al, 2024, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
201. Search progress of pyruvate kinase M2 (PKM2) in organ fibrosis
     Shumei Lv et al, 2024, Mol Biol Rep CrossRef
202. N6‐isopentenyladenosine inhibits aerobic glycolysis in glioblastoma cells by targeting PKM2 expression and activity
     Cristina Pagano et al, 2024, FEBS Open Bio CrossRef
203. Withaferin A Inhibits Liver Cancer Tumorigenesis by Suppressing Aerobic Glycolysis through the p53/IDH1/HIF-1α Signaling Axis
     Xiangyang Zhou et al, 2024, CCDT CrossRef
204. Temporal and regional expression changes and co‐staining patterns of metabolic and stemness‐related markers during glioblastoma progression
     Carolin Kubelt et al, 2024, Eur J of Neuroscience CrossRef
205. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions
     Yu Xia et al, 2023, Fish & Shellfish Immunology CrossRef
206. Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production
     Lyudmila V. Bel’skaya et al, 2024, CIMB CrossRef
207. Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer-STAT3 complex nuclear translocation.
     Yongbo Yu et al, 2024, Cancer Lett CrossRef
208. Recent Advances on PKM2 Inhibitors and Activators in Cancer Applications
     Peng Chen et al, 2024, CMC CrossRef
209. Enhancing 5-ALA-PDT efficacy against resistant tumor cells: Strategies and advances
     Safieh Ebrahimi et al, 2024, Life Sciences CrossRef
210. Immunometabolism Modulation in Therapy.
     Ezequiel Monferrer et al, 2021, Biomedicines CrossRef
211. Camptothecin Encapsulated in β-Cyclodextrin-EDTA-Fe3O4 Nanoparticles Induce Metabolic Reprogramming Repair in HT29 Cancer Cells through Epigenetic Modulation: A Bioinformatics Approach.
     Aisha Farhana et al, 2021, Nanomaterials (Basel) CrossRef
212. Oxidative Stress-mediated Protein Sulfenylation in Human Diseases: Past, Present, and Future
     Baoquan Mu et al, 2024, Redox Biology CrossRef
213. Computational Design, Chemical Synthesis, and Bioevaluation of Pyrimidinyl‐Indoles for Targeting Breast Cancer Cells
     Preethi Parameswaran et al, 2024, ChemistrySelect CrossRef
214. Altered metabolism in cancer: insights into energy pathways and therapeutic targets
     Muhammad Tufail et al, 2024, Mol Cancer CrossRef
215. Exogenous hydrogen sulfide enhances myogenic differentiation of C2C12 myoblasts under high palmitate stress
     Fangping Lu et al, 2024, Heliyon CrossRef
216. Exploring Hypoxia-Induced ncRNAs as Biomarkers and Therapeutic Targets in Lung Cancer
     Lakshmi Thangavelu et al, 2024, Pathology - Research and Practice CrossRef
217. Tumor metabolism and anti-tumor immunity
     Inna Serganova et al, 2024 CrossRef
218. Unraveling the interaction between a glycolytic regulator protein EhPpdk and an anaphase promoting complex protein EhApc10: yeast two hybrid screening, in vitro binding assays and molecular simulation study
     Suchetana Pal et al, 2024, Protein J CrossRef
219. Extracellular vesicles in cancers: mechanisms, biomarkers, and therapeutic strategies
     Yuxi Ma et al, 2024, MedComm CrossRef
220. The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury
     Shilei Cheng et al, 2024, Front. Immunol. CrossRef
221. Extracellular PKM2 Preserves Cardiomyocytes and Reduces Cardiac Fibrosis During Myocardial Infarction
     Yang Huang et al, 2024, IJMS CrossRef