1. Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein.
    Tianyi Zhu et al, 2018, J Mol Biol CrossRef
  2. m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
    Jiqin Liu et al, 2018, Biochem Biophys Res Commun CrossRef
  3. Critical Enzymatic Functions of FTO in Obesity and Cancer
    Xiaolan Deng et al, 2018, Front. Endocrinol. CrossRef
  4. It's complicated… m6A-dependent regulation of gene expression in cancer
    Christina M. Fitzsimmons et al, 2018, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms CrossRef
  5. RNA Modifications: Reversal Mechanisms And Cancer
    Roopa Thapar et al, 2018, Biochemistry CrossRef
  6. Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression
    JiaLing Chen et al, 2018, J Cancer Res Clin Oncol CrossRef
  7. Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
    Yue Li et al, 2019, Dig Dis Sci CrossRef
  8. RNAMethyPro: a biologically conserved signature of N6-methyladenosine regulators for predicting survival at pan-cancer level
    Raju Kandimalla et al, 2019, npj Precis. Onc. CrossRef
  9. Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma
    Zhuo-Xian Rong et al, 2019, Front. Oncol. CrossRef
  10. ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy
    Tomaš Pilžys et al, 2019, Sci Rep CrossRef
  11. N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
    Bin-bin Hu et al, 2019, Mol Cancer CrossRef
  12. The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium
    Ng Desi et al, 2019, Cells CrossRef
  13. N6-Methyladenosine: A Potential Breakthrough for Human Cancer.
    Lina Liu et al, 2020, Mol Ther Nucleic Acids CrossRef
  14. RNA N6-methyladenosine modification in solid tumors: new therapeutic frontiers
    Laleh Melstrom et al, 2020, Cancer Gene Ther CrossRef
  15. Writers, Readers and Erasers of RNA Modifications in Cancer
    Rosaura Esteve-Puig et al, 2020, Cancer Letters CrossRef
  16. FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13
    Shenxiang Liu et al, 2020, Experimental Cell Research CrossRef

  17. FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation


    Yudi Ding et al, 2020, OTT CrossRef
  18. Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes
    Michał Marcinkowski et al, 2020, IUBMB Life CrossRef
  19. FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression
    Mayumi Hirayama et al, 2020, Cell Reports CrossRef
  20. RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner.
    Xingya Guo et al, 2020, Mol Cancer CrossRef
  21. Mechanism of RNA modification N6-methyladenosine in human cancer.
    Zijian Zhou et al, 2020, Mol Cancer CrossRef
  22. RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy
    Meiyi Xiang et al, 2020, Epigenomics CrossRef
  23. FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy
    Lin Zhao et al, 2020, Pathology - Research and Practice CrossRef
  24. The emerging roles of N6-methyladenosine RNA methylation in human cancers
    Huafei Shen et al, 2020, Biomark Res CrossRef
  25. Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells
    Terisha Ghazi et al, 2020, Epigenetics CrossRef
  26. HDAC3-dependent transcriptional repression of FOXA2 regulates FTO/m6A/MYC signaling to contribute to the development of gastric cancer
    Zhi Yang et al, 2020, Cancer Gene Ther CrossRef
  27. RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells
    Nobuhiro Tsuruta et al, 2020, Biochemical and Biophysical Research Communications CrossRef
  28. Decreased ALKBH5, FTO, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis
    Qing Luo et al, 2020, BioMed Research International CrossRef
  29. Gene Signatures and Prognostic Values of m6A RNA Methylation Regulators in Ovarian Cancer
    Xiao Han et al, 2020, Cancer Control CrossRef
  30. The FTO Gene and Diseases: The Role of Genetic Polymorphism, Epigenetic Modifications, and Environmental Factors
    A. N. Kucher, 2020, Russ J Genet CrossRef
  31. N6-methyladenosine RNA modification in cancer therapeutic resistance: current status and perspectives
    Zhijie Xu et al, 2020, Biochemical Pharmacology CrossRef
  32. N6 -methyladenosine (m6A) RNA modification in human cancer.
    Fu-Chun Huo et al, 2020, Cell Prolif CrossRef
  33. Retrospective study of gene signatures and prognostic value of m6A regulatory factor in non-small cell lung cancer using TCGA database and the verification of FTO
    Hongjie Shi et al, 2020, Aging CrossRef

  34. To Develop and Validate the Combination of RNA Methylation Regulators for the Prognosis of Patients with Gastric Cancer


    Jun Zhang et al, 2020, OTT CrossRef
  35. The N6-Methyladenosine Features of mRNA and Aberrant Expression of m6A Modified Genes in Gastric Cancer and Their Potential Impact on the Risk and Prognosis
    Liang Sang et al, 2020, Front. Genet. CrossRef
  36. RNA methylations in human cancers
    Xiao Han et al, 2020, Seminars in Cancer Biology CrossRef
  37. Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5
    Dong Ma et al, 2020, Front. Cardiovasc. Med. CrossRef

  38. The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers


    Jin-yan Wang et al, 2020, OTT CrossRef
  39. Structural Insights Into m6A-Erasers: A Step Toward Understanding Molecule Specificity and Potential Antiviral Targeting
    Mahmoud Bayoumi et al, 2021, Front. Cell Dev. Biol. CrossRef
  40. Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation
    Shuitu Feng et al, 2021 CrossRef
  41. FTO modifies the m6A level of MALAT and promotes bladder cancer progression
    Le Tao et al, 2021, Clinical and Translational Medicine CrossRef
  42. The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels
    Kai Zhu et al, 2021, Life Sciences CrossRef
  43. Development and Validation of an m6A RNA Methylation Regulators-Based Signature for Predicting the Prognosis of Adrenocortical Carcinoma
    Chengquan Shen et al, 2021, Front. Endocrinol. CrossRef
  44. FTO regulates myoblast proliferation by controlling CCND1 expression in an m6A-YTHDF2-dependent manner.
    Kaiping Deng et al, 2021, Exp Cell Res CrossRef
  45. A brief review of RNA modification related database resources.
    Jiani Ma et al, 2021, Methods CrossRef
  46. Diet-Dependent Metabolic Regulation of DNA Double-Strand Break Repair in Cancer: More Choices on the Menu
    Anna de Polo et al, 2021, Cancer Prev Res CrossRef
  47. Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression
    Wei Song et al, 2021, Aging CrossRef
  48. Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase
    Michał Marcinkowski et al, 2021, IJMS CrossRef
  49. Identification of tectoridin as the inhibitor of FTO by isothermal titration calorimetric and spectroscopic methods
    Xitong Li et al, 2021, New J. Chem. CrossRef
  50. N 6 ‐methyladenosine Steers RNA Metabolism and Regulation in Cancer
    Shenghua Dong et al, 2021, Cancer Communications CrossRef
  51. Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin
    Yan Wang et al, 2021, Bioengineered CrossRef
  52. Methylation Landscape: Targeting Writer or Eraser to Discover Anti-Cancer Drug
    Wen-min Zhou et al, 2021, Front. Pharmacol. CrossRef
  53. sm6A RNA methylation and beyond – The epigenetic machinery and potential treatment options
    Sabrina Garbo et al, 2021, Drug Discovery Today CrossRef
  54. m6A modification of RNA and its role in cancer, with a special focus on lung cancer
    Raja Ishaq Nabi Khan et al, 2021, Genomics CrossRef
  55. Role of m6A methylation in occurrence and progression of digestive system malignancies
    Rui-Huang Liang et al, 2021, WCJD CrossRef
  56. Targeting the RNA demethylase FTO for cancer therapy
    Lin-Lin Zhou et al, 2021, RSC Chem. Biol. CrossRef
  57. Fat mass and obesity‐associated protein regulates tumorigenesis of arecoline‐promoted human oral carcinoma
    Xia Li et al, 2021, Cancer Med CrossRef
  58. The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma
    Qi Yao et al, 2021, Front. Oncol. CrossRef
  59. Structural characteristics of small-molecule inhibitors targeting FTO demethylase
    Shuting Gao et al, 2021, Future Medicinal Chemistry CrossRef
  60. Emerging Roles of N6-Methyladenosine Demethylases and Its Interaction with Environmental Toxicants in Digestive System Cancers.
    Caiping Liu et al, 2021, Cancer Manag Res CrossRef
  61. The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients
    Wenfa Yi et al, 2021, Bioengineered CrossRef
  62. Cross-talk and clinical value of m[superscript 6]A regulatory gene in bladder cancer
    Ben-zheng Zhou et al, 2021, BMC Urol CrossRef
  63. Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection
    Dingxue Hu et al, 2021, Sci Rep CrossRef
  64. Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
    Qing-Kang Zheng et al, 2021, OTT CrossRef
  65. Novel evidence for m6A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer.
    Tadanobu Shimura et al, 2022, Br J Cancer CrossRef
  66. FTO promotes tumour proliferation in bladder cancer via the FTO/miR-576/CDK6 axis in an m6A-dependent manner
    Guanwen Zhou et al, 2021, Cell Death Discov. CrossRef
  67. Expression profiles and prognostic roles of m6A writers, erasers and readers in gastric cancer
    Jing-Jing Jing et al, 2021, Future Oncology CrossRef
  68. Non-Coding RNA m6A Modification in Cancer: Mechanisms and Therapeutic Targets
    Da-Hong Chen et al, 2021, Front. Cell Dev. Biol. CrossRef
  69. FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m6A-YTHDF2-dependent manner.
    Aoshuang Xu et al, 2022, Mol Ther CrossRef
  70. Construction and validation of m 6 A RNA methylation regulators associated prognostic model for gastrointestinal cancer
    Yandong Miao et al, 2022, IET Systems Biology CrossRef
  71. METTL14-mediated N6-methyladenosine modification of Pten mRNA inhibits tumour progression in clear-cell renal cell carcinoma
    Lili Zhang et al, 2022, Br J Cancer CrossRef
  72. FTO in cancer: functions, molecular mechanisms, and therapeutic implications
    Yangchan Li et al, 2022, Trends in Cancer CrossRef
  73. Risk Score Prediction Model of Prognosis in GC Patients by Age and Gender Combined With m6A Modification Genes FTO and RBM15
    Limin Yue et al, 2022, Front. Cell Dev. Biol. CrossRef
  74. Solution structure ensemble of human obesity-associated protein FTO reveals druggable surface pockets at the interface between the N- and C-terminal domain
    Balabhadra Khatiwada et al, 2022, Journal of Biological Chemistry CrossRef
  75. FTO Prevents Thyroid Cancer Progression by SLC7A11 m6A Methylation in a Ferroptosis-Dependent Manner.
    Fei-Hong Ji et al, 2022, Front Endocrinol (Lausanne) CrossRef
  76. The Role of FTO in Tumors and Its Research Progress
    Hao Wei et al, 2022, CMC CrossRef
  77. FTO Regulates Apoptosis in CPB2-Treated IPEC-J2 Cells by Targeting Caspase 3 Apoptotic Protein
    Jiaojiao Yang et al, 2022, Animals CrossRef
  78. Comprehensive Analysis of Regulatory Networks of m6A Regulators and Reveals Prognosis Biomarkers in Sarcoma
    Boran Pang et al, 2022, Front. Oncol. CrossRef
  79. Progress and application of epitranscriptomic m6A modification in gastric cancer
    Yitian Xu et al, 2022, RNA Biology CrossRef
  80. Fat mass and obesity‐associated protein regulates arecoline‐exposed oral cancer immune response through programmed cell death‐ligand 1
    Xia Li et al, 2022, Cancer Science CrossRef
  81. Comprehensive mutations analyses of FTO (fat mass and obesity-associated gene) and their effects on FTO’s substrate binding implicated in obesity
    Rakesh Kumar et al, 2022, Front. Nutr. CrossRef
  82. Rational Design and Optimization of m6A-RNA Demethylase FTO Inhibitors as Anticancer Agents
    Sarah Huff et al, 2022, J. Med. Chem. CrossRef
  83. The controversial role and therapeutic development of the m6A demethylase FTO in renal cell carcinoma
    Dalin Zhang et al, 2022, Translational Oncology CrossRef
  84. Integrated Analyses of m6A Regulator-Based Signature on Its Clinical Application and Immunogenomic Landscape in Stomach Adenocarcinoma
    Lan Zhang et al, 2022, BioMed Research International CrossRef
  85. FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value
    Chunying Zheng et al, 2022, Experimental Cell Research CrossRef
  86. Sensitive Detection of Fat Mass and Obesity-Associated Protein based on Terminal Deoxynucleotidyl Transferase-Mediated Signal Amplification
    Xuemei Ma et al, 2022, Microchemical Journal CrossRef
  87. Prognostic and clinicopathological value of m6A regulators in human cancers: a meta-analysis
    Zhangci Su et al, 2022, Aging CrossRef
  88. Targeting FTO Suppresses Pancreatic Carcinogenesis via Regulating Stem Cell Maintenance and EMT Pathway.
    Rachana Garg et al, 2022, Cancers (Basel) CrossRef
  89. Interplay between m 6 A epitranscriptome and epigenome in cancer: current knowledge and therapeutic perspectives
    Guglielmo Bove et al, 2022, Intl Journal of Cancer CrossRef
  90. Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability
    Chaojie Bu et al, 2022, Clin Transl Oncol CrossRef
  91. Anti‐cancer effect of entacaponeon esophageal cancer cells via apoptosis induction and cell cycle modulation
    Fahimeh Ramedani et al, 2022, Cancer Reports CrossRef
  92. Interactions dietary components with expression level of breast cancer-related genes
    Fatemeh Bourbour et al, 2022, Egypt J Med Hum Genet CrossRef
  93. Targeting fat mass and obesity-associated protein mitigates human colorectal cancer growth in vitro and in a murine model
    Thuy Phan et al, 2023, Front. Oncol. CrossRef
  94. RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4
    Jie Fang et al, 2023, Mol Med CrossRef
  95. FTO regulates the DNA damage response via effects on cell-cycle progression
    Weiying Liu et al, 2023, Mutation Research/Genetic Toxicology and Environmental Mutagenesis CrossRef
  96. Effect of demethyltransferase FTO on tumor progression
    LING SHENG et al, 2022 CrossRef
  97. Development and validation of focal adhesion-related genes signature in gastric cancer
    Guanghui Zhao et al, 2023, Front. Genet. CrossRef
  98. Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy
    Yuxuan Zhu et al, 2023, Med Oncol CrossRef
  99. DNA 6mA demethylase ALKBH1 regulates DDX18 expression to promote proliferation of human head and neck squamous cell carcinoma
    Chengli Guo et al, 2023, Cell Oncol. CrossRef
  100. Role of N6-methyladenosine RNA modification in gastric cancer.
    Si-Qi Ding et al, 2023, Cell Death Discov CrossRef
  101. Homogeneous Electrochemiluminescence for Highly Sensitive Determination of Demethylase FTO Based on Target-Regulated DNAzyme Cleavage and Host–Guest Interaction
    Xia Yang et al, 2023, Anal. Chem. CrossRef
  102. FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer
    Jintao Mi et al, 2023 CrossRef
  103. METTL3 regulates FAM83D m6A modification to accelerate tumorigenesis of triple-negative breast cancer via the Wnt/β-catenin pathway
    Xiaodong Yu et al, 2023, Toxicology in Vitro CrossRef
  104. RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer
    Yuexing Lai et al, 2024, BMC Gastroenterol CrossRef
  105. MiR-186-5p prevents hepatocellular carcinoma progression by targeting methyltransferase-like 3 that regulates m6A-mediated stabilization of follistatin-like 5
    Shuoshuo Ma et al, 2024, Heliyon CrossRef
  106. Sequencing, Physiological Regulation, and Representative Disease Research Progress of RNA m6A Modification
    Xiaoqian Chen et al, 2024, Pharmaceutical Fronts CrossRef
  107. FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway
    Rongli Wang et al, 2024, J Ovarian Res CrossRef
  108. Demethylases in tumors and the tumor microenvironment: Key modifiers of N6-methyladenosine methylation
    Junchen Guo et al, 2024, Biomedicine & Pharmacotherapy CrossRef
  109. Mechanisms and clinical landscape of N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers
    Dan-Hua Zhu et al, 2024, Mol Cell Biochem CrossRef
  110. An α-ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein
    Daniel Burns et al, 2024, Proc. Natl. Acad. Sci. U.S.A. CrossRef
  111. The Emerging Role of Epitranscriptomics in Cancer: Focus on Urological Tumors
    João Lobo et al, 2018, Genes CrossRef
  112. Targeting RNA N6-methyladenosine modification—— a novel therapeutic target for HER2- positive gastric cancer
    Lijun Jia et al, 2024, Front. Oncol. CrossRef
  113. FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms
    Sarah Kassem Azzam et al, 2022, IJMS CrossRef
  114. Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases
    Yazhen You et al, 2022, IJMS CrossRef
  115. Medicinal chemistry aspects of fat mass and obesity associated protein: structure, function and inhibitors
    Changyu Ren et al, 2024, Future Medicinal Chemistry CrossRef
  116. Electrochemical detection of FTO with N3-kethoxal labeling and MazF cleavage
    Chen Chen et al, 2024, RSC Adv. CrossRef
  117. Meta-analysis of FTO expression on the clinicopathologic characteristics and prognosis of gastric cancer
    Ciba Zhu et al, 2024 CrossRef
  118. The diverse landscape of RNA modifications in cancer development and progression
    Hyung Seok Kim et al, 2024, Genes Genom CrossRef
  119. m6A demethylation of NNMT in CAFs promotes gastric cancer progression by enhancing macrophage M2 polarization
    Tsz Kin Mak et al, 2024, Cancer Letters CrossRef