Open Access

Daphnetin inhibits inflammation in the NZB/W F1 systemic lupus erythematosus murine model via inhibition of NF-κB activity

  • Authors:
    • Min Li
    • Xiaowei Shi
    • Fangru Chen
    • Fei Hao
  • View Affiliations

  • Published online on: December 13, 2016     https://doi.org/10.3892/etm.2016.3971
  • Pages: 455-460
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Daphnetin is a compound extracted from Chinese medicinal herbs, which exerts analgesic and anti-inflammatory effects. The present study aimed to investigate the potential therapeutic effect of daphnetin on inflammation in the NZB/W F1 systemic lupus erythematosus (SLE) murine model. Female NZB/WF1 mice (age, 16-18 weeks) were intraperitoneally injected with daphnetin once a day for 12 weeks. It was revealed that daphnetin treatment significantly increased animal survival rates, reduced renal damage and blood urea nitrogen levels, and suppressed serum autoantibody production in the SLE‑prone NZB/W F1 mice. In addition, daphnetin treatment significantly decreased the serum levels of tumor necrosis factor‑α and interleukin‑6, inhibited nuclear factor (NF)-κB activity, suppressed the protein expression of nuclear factor of activated T-cells and promoted A20 protein expression in SLE‑prone NZB/W F1 mice. In conclusion, daphnetin inhibited inflammation in the NZB/W F1 murine SLE model via inhibition of NF‑κB mediated by upregulation of A20.

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February-2017
Volume 13 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Li M, Shi X, Chen F and Hao F: Daphnetin inhibits inflammation in the NZB/W F1 systemic lupus erythematosus murine model via inhibition of NF-κB activity. Exp Ther Med 13: 455-460, 2017
APA
Li, M., Shi, X., Chen, F., & Hao, F. (2017). Daphnetin inhibits inflammation in the NZB/W F1 systemic lupus erythematosus murine model via inhibition of NF-κB activity. Experimental and Therapeutic Medicine, 13, 455-460. https://doi.org/10.3892/etm.2016.3971
MLA
Li, M., Shi, X., Chen, F., Hao, F."Daphnetin inhibits inflammation in the NZB/W F1 systemic lupus erythematosus murine model via inhibition of NF-κB activity". Experimental and Therapeutic Medicine 13.2 (2017): 455-460.
Chicago
Li, M., Shi, X., Chen, F., Hao, F."Daphnetin inhibits inflammation in the NZB/W F1 systemic lupus erythematosus murine model via inhibition of NF-κB activity". Experimental and Therapeutic Medicine 13, no. 2 (2017): 455-460. https://doi.org/10.3892/etm.2016.3971