Open Access

Value of the combined examination of Cys-C and HbA1c for diagnosis of early renal injury in pediatric diabetes

  • Authors:
    • Tong Qian
    • Lijun Tian
    • Yanyan Li
    • Zhenru Zhang
    • Xiuying Tian
    • Dan Sun
  • View Affiliations

  • Published online on: December 12, 2016     https://doi.org/10.3892/etm.2016.3967
  • Pages: 515-518
  • Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The objective of the present study was to evaluate the combined application of measuring cystatin C (Cys-C) and hemoglobin A1c (HbA1c) levels for early renal injury in pediatric patients with type 2 diabetes. A total of 130 children with type 2 diabetes admitted to our hospital from May 2013 to July 2015 were selected. Patients were divided according to whether there was complication of renal injury. In group A (n=65), the patients had renal injury and in group B (n=65), the patients did not have renal injury. The levels of Cys-C and HbA1c in the two groups were examined. The results showed that the levels of Cys-C and HbA1c of patients in group A were significantly higher than those in group B (P<0.05), and the positive rate of the combined examination of Cys-C and HbA1c in group A was 92.3%, and was higher than that of the individual examinations of either Cys-C or HbA1c (P<0.05). The Spearman's correlation coefficient analysis was applied to group B and showed that Cys-C was positively correlated with HbA1c (r=0.842, P<0.05). From analysis of the receiver operating characteristic curves, the combined examination of Cys-C and HbA1c surpassed the individual examinations of Cys-C or HbA1c in sensitivity and specificity (P<0.05). In conclusion, the positive detection rate of early renal injury was significantly increased by the combined examination of Cys-C and HbA1c in pediatric patients with type 2 diabetes, which is beneficial for early identification and diagnosis of this diseases and is worthy of clinical application.

Related Articles

Journal Cover

February-2017
Volume 13 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Qian T, Tian L, Li Y, Zhang Z, Tian X and Sun D: Value of the combined examination of Cys-C and HbA1c for diagnosis of early renal injury in pediatric diabetes. Exp Ther Med 13: 515-518, 2017
APA
Qian, T., Tian, L., Li, Y., Zhang, Z., Tian, X., & Sun, D. (2017). Value of the combined examination of Cys-C and HbA1c for diagnosis of early renal injury in pediatric diabetes. Experimental and Therapeutic Medicine, 13, 515-518. https://doi.org/10.3892/etm.2016.3967
MLA
Qian, T., Tian, L., Li, Y., Zhang, Z., Tian, X., Sun, D."Value of the combined examination of Cys-C and HbA1c for diagnosis of early renal injury in pediatric diabetes". Experimental and Therapeutic Medicine 13.2 (2017): 515-518.
Chicago
Qian, T., Tian, L., Li, Y., Zhang, Z., Tian, X., Sun, D."Value of the combined examination of Cys-C and HbA1c for diagnosis of early renal injury in pediatric diabetes". Experimental and Therapeutic Medicine 13, no. 2 (2017): 515-518. https://doi.org/10.3892/etm.2016.3967