Open Access

EASApprox® skin‑stretching system: A secure and effective method to achieve wound closure

  • Authors:
    • Mingzhi Song
    • Zhen Zhang
    • Tao Liu
    • Song Liu
    • Gang Li
    • Zhaochang Liu
    • Jingyang Huang
    • Song Chen
    • Linan Li
    • Li Guo
    • Yang Qiu
    • Jiajia Wan
    • Yuejian Liu
    • Tao Wu
    • Xiaoyong Wang
    • Ming Lu
    • Shouyu Wang
  • View Affiliations

  • Published online on: June 1, 2017     https://doi.org/10.3892/etm.2017.4539
  • Pages:531-538
0

Abstract

Large skin defects are commonly observed in the clinic and have attracted much attention recently. Therefore, finding an effective solution for large skin defects is a global problem. The objective of the present study was to assess the effectiveness of the EASApprox® skin‑stretching system for closing large skin defects. Skin defects (5x5 cm) were created on the forearms of 9 Bama miniature pigs, which were randomly divided into the following three groups: Direct suture, the new EASApprox® skin‑stretching device and Kirschner wires. Microcirculation was assessed before surgery and after wound closure. Following the different treatments, the defects were sutured, and wound healing was assessed based on a clinical score. Furthermore, microscopic and ultramicroscopic structures were evaluated, including collagen, elastic fibers and the microvessel density. Significant differences in the clinical score and microvessel density were observed among the groups. Additionally, the mean length obtained for elastic fibers was larger than that obtained for the other two groups. Finally, the new EASApprox® skin‑stretching device resulted in successful wound management and with only minor side effects on skin histology and microcirculation. Therefore, this method has the potential to be used for healing large skin defects.

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Journal Cover

July 2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

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APA
Song, M., Zhang, Z., Liu, T., Liu, S., Li, G., Liu, Z. ... Wang, S. (2017). EASApprox® skin‑stretching system: A secure and effective method to achieve wound closure. Experimental and Therapeutic Medicine, 14, 531-538. https://doi.org/10.3892/etm.2017.4539
MLA
Song, M., Zhang, Z., Liu, T., Liu, S., Li, G., Liu, Z., Huang, J., Chen, S., Li, L., Guo, L., Qiu, Y., Wan, J., Liu, Y., Wu, T., Wang, X., Lu, M., Wang, S."EASApprox® skin‑stretching system: A secure and effective method to achieve wound closure". Experimental and Therapeutic Medicine 14.1 (2017): 531-538.
Chicago
Song, M., Zhang, Z., Liu, T., Liu, S., Li, G., Liu, Z., Huang, J., Chen, S., Li, L., Guo, L., Qiu, Y., Wan, J., Liu, Y., Wu, T., Wang, X., Lu, M., Wang, S."EASApprox® skin‑stretching system: A secure and effective method to achieve wound closure". Experimental and Therapeutic Medicine 14, no. 1 (2017): 531-538. https://doi.org/10.3892/etm.2017.4539