Open Access

Limethason reduces airway inflammation in a murine model of ovalbumin-induced chronic asthma without causing side effects

  • Authors:
    • Siyu Li
    • Zhiping Miao
    • Ye Tian
    • Haoyu Wang
    • Shuai Wang
    • Tianyuan He
    • Yue Yang
    • Peng Wang
    • Mengyao Ma
    • Tuanmin Yang
    • Tao Chen
    • Zhiyong Liu
    • Junhong Gao
    • Chu Chen
    • Airong Qian
  • View Affiliations

  • Published online on: January 4, 2018     https://doi.org/10.3892/etm.2018.5691
  • Pages: 2269-2276
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Airway inflammation is the major pathological feature of asthma. Thus, the current therapeutic strategy for asthma is to control inflammation. Limethason, an anti‑inflammation drug, is widely used in rheumatoid arthritis treatment. The aim of the present study was to detect the anti‑inflammatory effect and side effects of limethason on airways that were sensitized with ovalbumin in a murine model of chronic asthma. In the present study, BALB/c mice were sensitized with ovalbumin. Airway hyperresponsiveness was estimated, and hematoxylin and eosin staining, Periodic acid‑Schiff staining and bronchoalveolar lavage were used to detect the effect on chronic asthma. Limethason effectively reduced airway hyperresponsiveness, and inhibited inflammatory cell infiltration and mucus secretion. Bronchoalveolar lavage fluid analysis revealed that limethason suppressed levels of airway eosinophils. In the period of treatment, limethason exhibited no influence on morphology of the femoral head, bone mineral content or bone mineral density, which were detected by histological studies and dual‑energy X‑ray absorptiometry. The index of liver, spleen, kidney, gastrocnemius and brown adipose tissue also demonstrated that limethason had no adverse effects on organs and tissues. The present study revealed that limethason could effectively reduce inflammation in an asthma mouse model without side effects. Therefore, limethason may have therapeutic potential for treating chronic asthma clinically.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li S, Miao Z, Tian Y, Wang H, Wang S, He T, Yang Y, Wang P, Ma M, Yang T, Yang T, et al: Limethason reduces airway inflammation in a murine model of ovalbumin-induced chronic asthma without causing side effects. Exp Ther Med 15: 2269-2276, 2018
APA
Li, S., Miao, Z., Tian, Y., Wang, H., Wang, S., He, T. ... Qian, A. (2018). Limethason reduces airway inflammation in a murine model of ovalbumin-induced chronic asthma without causing side effects. Experimental and Therapeutic Medicine, 15, 2269-2276. https://doi.org/10.3892/etm.2018.5691
MLA
Li, S., Miao, Z., Tian, Y., Wang, H., Wang, S., He, T., Yang, Y., Wang, P., Ma, M., Yang, T., Chen, T., Liu, Z., Gao, J., Chen, C., Qian, A."Limethason reduces airway inflammation in a murine model of ovalbumin-induced chronic asthma without causing side effects". Experimental and Therapeutic Medicine 15.3 (2018): 2269-2276.
Chicago
Li, S., Miao, Z., Tian, Y., Wang, H., Wang, S., He, T., Yang, Y., Wang, P., Ma, M., Yang, T., Chen, T., Liu, Z., Gao, J., Chen, C., Qian, A."Limethason reduces airway inflammation in a murine model of ovalbumin-induced chronic asthma without causing side effects". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2269-2276. https://doi.org/10.3892/etm.2018.5691