Open Access

Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer

  • Authors:
    • Zhaoyang Yang
    • Fang Yang
    • Yingli Zhang
    • Xin Wang
    • Jiong Shi
    • Hongjiao Wei
    • Fengwei Sun
    • Yan Yu
  • View Affiliations

  • Published online on: January 19, 2018     https://doi.org/10.3892/etm.2018.5773
  • Pages: 2837-2843
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study explored the relationship between Girdin protein expression and the survival rate of patients with lung carcinoma. A total of 334 lung cancer specimens, 20 benign lung disease tissue sections and 24 fresh tissues from patients with lung carcinoma were analyzed by immunohistochemistry and western blotting. Girdin protein was expressed in 130/334 (38.93%) of the cases examined. Girdin protein expression was correlated with tumor/node/metastasis stage (P<0.001), lymph node metastasis (P=0.001), distant metastasis (P<0.001) and specimen sites (P=0.034). Girdin expression was also correlated with signal transducer and activator of transcription 3 (STAT3) expression (P<0.001). Patients with high Girdin and STAT3 expression had a significantly poorer prognosis compared with those with low/high, high/low or low/low expression (P<0.001). In summary, Girdin may be a prognostic marker of lung cancer and serve as a biomarker for metastasis.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yang Z, Yang F, Zhang Y, Wang X, Shi J, Wei H, Sun F and Yu Y: Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer. Exp Ther Med 15: 2837-2843, 2018
APA
Yang, Z., Yang, F., Zhang, Y., Wang, X., Shi, J., Wei, H. ... Yu, Y. (2018). Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer. Experimental and Therapeutic Medicine, 15, 2837-2843. https://doi.org/10.3892/etm.2018.5773
MLA
Yang, Z., Yang, F., Zhang, Y., Wang, X., Shi, J., Wei, H., Sun, F., Yu, Y."Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer". Experimental and Therapeutic Medicine 15.3 (2018): 2837-2843.
Chicago
Yang, Z., Yang, F., Zhang, Y., Wang, X., Shi, J., Wei, H., Sun, F., Yu, Y."Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2837-2843. https://doi.org/10.3892/etm.2018.5773