Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection

  • Authors:
    • Bin Zhou
    • Defeng Zhang
  • View Affiliations

  • Published online on: January 24, 2018     https://doi.org/10.3892/etm.2018.5790
  • Pages: 2985-2989
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Abstract

Infection following orthopedic surgery is a major complication that can have serious implications on patient health. The present study aimed to investigate the antibacterial effects of bacteriocins obtained from Lactobacillus rhamnosus on a rabbit model of Staphylococcus aureus infection following knee replacement surgery. Blood samples were collected 1, 2, 3, 4 and 5 days after bacteriocin injection, and C‑reactive protein (CRP) and interleukin (IL)‑6 levels were measured using commercial ELISA kits. In addition, biofilm formation was evaluated by fluorescence microscopy. Bacteriocins were identified to exhibit significant inhibitory effects on Staphylococcus aureus biofilm formation, and on CRP and IL‑6 levels in the serum, following surgery and infection (all P<0.05 vs. the control group). The results of the present study indicate that bacteriocins are a potential agent for the prevention of orthopedic postoperative infections.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou B and Zhou B: Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection. Exp Ther Med 15: 2985-2989, 2018
APA
Zhou, B., & Zhou, B. (2018). Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection. Experimental and Therapeutic Medicine, 15, 2985-2989. https://doi.org/10.3892/etm.2018.5790
MLA
Zhou, B., Zhang, D."Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection". Experimental and Therapeutic Medicine 15.3 (2018): 2985-2989.
Chicago
Zhou, B., Zhang, D."Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2985-2989. https://doi.org/10.3892/etm.2018.5790