Open Access

Salidroside mediates apoptosis and autophagy inhibition in concanavalin A‑induced liver injury

  • Authors:
    • Jiao Feng
    • Peiqin Niu
    • Kan Chen
    • Liwei Wu
    • Tong Liu
    • Shizan Xu
    • Jingjing Li
    • Sainan Li
    • Wenwen Wang
    • Xiya Lu
    • Qiang Yu
    • Ning Liu
    • Ling Xu
    • Fan Wang
    • Weiqi Dai
    • Yujing Xia
    • Xiaoming Fan
    • Chuanyong Guo
  • View Affiliations

  • Published online on: April 12, 2018     https://doi.org/10.3892/etm.2018.6053
  • Pages:4599-4614
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Salidroside (Sal) is a glycoside extract from Rhodiola rosea L. with anti‑inflammatory, antioxidant, anticancer and cardioprotective properties. The present study explored the protective effects and the possible mechanisms of Sal on concanavalin A (ConA)‑induced liver injury in mice. Balb/C mice were divided into five groups: Normal control (injected with normal saline), ConA (25 mg/kg), Sal (10 mg/kg) +ConA, Sal (20 mg/kg) + ConA (Sal injected 2 h prior to ConA injection) and Sal (20 mg/kg) only. The serum levels of liver enzymes, pro‑inflammatory cytokines, and apoptosis‑ and autophagy‑associated marker proteins were determined at 2, 8 and 24 h after ConA injection. LY294002 was further used to verify whether the phosphoinositide 3‑kinase (PI3K)/Akt pathway was activated. Primary hepatocytes were isolated to verify the effect of Sal in vitro. The results indicated that Sal was a safe agent to reduce pathological damage and serum liver enzymes in ConA‑induced liver injury. Sal suppressed inflammatory reactions in serum and liver tissues, and activated the PI3K/Akt signaling pathway to inhibit apoptosis and autophagy in vivo and in vitro, which could be reversed by LY294002. In conclusion, Sal attenuated ConA‑induced liver injury by modulating PI3K/Akt pathway‑mediated apoptosis and autophagy in mice.

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June 2018
Volume 15 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Feng, J., Niu, P., Chen, K., Wu, L., Liu, T., Xu, S. ... Guo, C. (2018). Salidroside mediates apoptosis and autophagy inhibition in concanavalin A‑induced liver injury. Experimental and Therapeutic Medicine, 15, 4599-4614. https://doi.org/10.3892/etm.2018.6053
MLA
Feng, J., Niu, P., Chen, K., Wu, L., Liu, T., Xu, S., Li, J., Li, S., Wang, W., Lu, X., Yu, Q., Liu, N., Xu, L., Wang, F., Dai, W., Xia, Y., Fan, X., Guo, C."Salidroside mediates apoptosis and autophagy inhibition in concanavalin A‑induced liver injury". Experimental and Therapeutic Medicine 15.6 (2018): 4599-4614.
Chicago
Feng, J., Niu, P., Chen, K., Wu, L., Liu, T., Xu, S., Li, J., Li, S., Wang, W., Lu, X., Yu, Q., Liu, N., Xu, L., Wang, F., Dai, W., Xia, Y., Fan, X., Guo, C."Salidroside mediates apoptosis and autophagy inhibition in concanavalin A‑induced liver injury". Experimental and Therapeutic Medicine 15, no. 6 (2018): 4599-4614. https://doi.org/10.3892/etm.2018.6053