The significance of Elf-1 expression in epithelial ovarian carcinoma

  • Authors:
    • Noriyuki Takai
    • Tami Miyazaki
    • Masakazu Nishida
    • Kaei Nasu
    • Isao Miyakawa
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/ijmm.12.3.349
  • Pages: 349-354
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Abstract

Elf-1 is a member of the Ets transcription factor family that regulates the genes involved in cellular growth and differentiation. Enhanced expression of Elf-1 has been reported in prostate cancer, breast cancer, and osteosarcoma. The aim of this study was to elucidate the involvement of Elf-1 in ovarian carcinogenesis. We analyzed serial frozen tissue sections from 26 patients with epithelial ovarian carcinoma and 10 patients with benign cystadenoma of ovary for Elf-1 protein expression, using fluorescent immunohistochemistry. We analyzed the relationship between the percentages of Elf-1-stained cells and patient characteristics, including histological classification, clinical stage, histological grade, clinical outcome, and survival rate. Elf-1 was weakly detected in some benign cystadenomas (0-5.5%). There was, however, abundant Elf-1 immunoreactivity in the nucleus of the ovarian carcinoma cells along with a little cytoplasmic staining. Scoring on the basis of the percentage of nuclear-positive cells indicated that nuclear Elf-1 expression was significantly associated with PCNA-labeling index (p=0.04), clinical stage (p<0.01), histological grade (p<0.01), and clinical outcome (p=0.02). However, there was no relationship between Elf-1 expression and histological classification. Survival data were available for all patients and demonstrated that Elf-1 expression was significantly associated with poor prognosis (p<0.01). Our results demonstrate that Elf-1 expression in ovarian carcinoma correlates with the malignant potential of this tumor.

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September 2003
Volume 12 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Takai N, Miyazaki T, Nishida M, Nasu K and Miyakawa I: The significance of Elf-1 expression in epithelial ovarian carcinoma. Int J Mol Med 12: 349-354, 2003.
APA
Takai, N., Miyazaki, T., Nishida, M., Nasu, K., & Miyakawa, I. (2003). The significance of Elf-1 expression in epithelial ovarian carcinoma. International Journal of Molecular Medicine, 12, 349-354. https://doi.org/10.3892/ijmm.12.3.349
MLA
Takai, N., Miyazaki, T., Nishida, M., Nasu, K., Miyakawa, I."The significance of Elf-1 expression in epithelial ovarian carcinoma". International Journal of Molecular Medicine 12.3 (2003): 349-354.
Chicago
Takai, N., Miyazaki, T., Nishida, M., Nasu, K., Miyakawa, I."The significance of Elf-1 expression in epithelial ovarian carcinoma". International Journal of Molecular Medicine 12, no. 3 (2003): 349-354. https://doi.org/10.3892/ijmm.12.3.349