Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects

  • Authors:
    • Kaname Nakatani
    • Katsura Noma
    • Junji Nishioka
    • Yasunari Kasai
    • Kohei Morioka
    • Akira Katsuki
    • Yasuko Hori
    • Yutaka Yano
    • Yasuhiro Sumida
    • Hideo Wada
    • Tsutomu Nobori
  • View Affiliations

  • Published online on: January 1, 2005     https://doi.org/10.3892/ijmm.15.1.173
  • Pages: 173-177
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Abstract

Adiponectin is an adipocyte-secreted protein that is known to modulate insulin sensitivity and glucose homeostasis. A number of genetic variations have been studied. Among them, two single-nucleotide polymorphisms (SNP45T>G, SNP276G>T) showed an association with type 2 diabetes in the Japanese population. In this study, we examined the association between these SNPs and risk factors of type 2 diabetes in 194 non-diabetic Japanese subjects. SNP45 was associated with insulin sensitivity (determined by HOMA-IR, p=0.046) and obesity (body mass index; BMI, p=0.043). SNP276 showed a stronger association with HOMA-IR (p=0.018) and BMI (p=0.017). However, neither SNP had an association with insulin secretion (insulinogenic index) and plasma lipid levels. Moreover, a linkage dis-equilibrium was observed between SNP45 and SNP276. Carriers with SNP45G-SNP276G haplotype had higher BMI (p=0.034) and carriers with SNP45T-SNP276T haplotype had lower BMI (p=0.005) and HOMA-IR (p=0.037). Adiponectin gene variations showed an association with obesity and insulin sensitivity, and adiponectin genotypes may predict the increasing risk for type 2 diabetes in non-diabetic subjects.

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January 2005
Volume 15 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nakatani K, Noma K, Nishioka J, Kasai Y, Morioka K, Katsuki A, Hori Y, Yano Y, Sumida Y, Wada H, Wada H, et al: Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects. Int J Mol Med 15: 173-177, 2005.
APA
Nakatani, K., Noma, K., Nishioka, J., Kasai, Y., Morioka, K., Katsuki, A. ... Nobori, T. (2005). Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects. International Journal of Molecular Medicine, 15, 173-177. https://doi.org/10.3892/ijmm.15.1.173
MLA
Nakatani, K., Noma, K., Nishioka, J., Kasai, Y., Morioka, K., Katsuki, A., Hori, Y., Yano, Y., Sumida, Y., Wada, H., Nobori, T."Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects". International Journal of Molecular Medicine 15.1 (2005): 173-177.
Chicago
Nakatani, K., Noma, K., Nishioka, J., Kasai, Y., Morioka, K., Katsuki, A., Hori, Y., Yano, Y., Sumida, Y., Wada, H., Nobori, T."Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects". International Journal of Molecular Medicine 15, no. 1 (2005): 173-177. https://doi.org/10.3892/ijmm.15.1.173