Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation

  • Authors:
    • Tetsuya Beppu
    • Kazushi Sugimoto
    • Katsuya Shiraki
    • Masahiko Tameda
    • Satoko Kusagawa
    • Keiichiro Nojiri
    • Junichiro Tanaka
    • Norihiko Yamamoto
    • Yoshiyuki Takei
    • Haruyuki Takaki
    • Junji Uraki
    • Atsuhiro Nakatsuka
    • Koichiro Yamakado
    • Kan Takeda
  • View Affiliations

  • Published online on: September 1, 2010     https://doi.org/10.3892/ijmm_00000482
  • Pages: 425-433
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Abstract

The aim of this study was to elucidate the importance of three tumor markers, α-fetoprotein (AFP), Lens culinaris agglutinin A-reactive fraction of AFP (AFP-L3), and des-γ-carboxy prothrombin (DCP), for detecting and predicting the recurrence of hepatocellular carcinomas (HCCs). A total of 108 patients with initial non-advanced HCC who underwent curative radiofrequency ablation (RFA) in our hospital were enrolled in this study. The effectiveness of the three tumor markers for detecting recurrence and recurrence-free survival was analyzed. Positivity of these three makers was not markedly increased at the first or second recurrence. In addition, there was no significant correlation between the initial and recurrent levels of each tumor marker. The tumor marker that was positive at the time of initial HCC was not necessarily positive at recurrence. The tumor marker levels at recurrence were not correlated with pre-ablation levels. No significant correlation was found in the tumor marker values between pre-ablation and the time of recurrence. On multivariate analysis, high AFP-L3 levels (≥10%) were significantly predictive of recurrence-free survival. All three tumor markers should be routinely measured to detect recurrence during follow-up after RFA. Especially high AFP-L3 levels should be followed closely.

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September 2010
Volume 26 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Beppu T, Sugimoto K, Shiraki K, Tameda M, Kusagawa S, Nojiri K, Tanaka J, Yamamoto N, Takei Y, Takaki H, Takaki H, et al: Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation . Int J Mol Med 26: 425-433, 2010.
APA
Beppu, T., Sugimoto, K., Shiraki, K., Tameda, M., Kusagawa, S., Nojiri, K. ... Takeda, K. (2010). Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation . International Journal of Molecular Medicine, 26, 425-433. https://doi.org/10.3892/ijmm_00000482
MLA
Beppu, T., Sugimoto, K., Shiraki, K., Tameda, M., Kusagawa, S., Nojiri, K., Tanaka, J., Yamamoto, N., Takei, Y., Takaki, H., Uraki, J., Nakatsuka, A., Yamakado, K., Takeda, K."Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation ". International Journal of Molecular Medicine 26.3 (2010): 425-433.
Chicago
Beppu, T., Sugimoto, K., Shiraki, K., Tameda, M., Kusagawa, S., Nojiri, K., Tanaka, J., Yamamoto, N., Takei, Y., Takaki, H., Uraki, J., Nakatsuka, A., Yamakado, K., Takeda, K."Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation ". International Journal of Molecular Medicine 26, no. 3 (2010): 425-433. https://doi.org/10.3892/ijmm_00000482