PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review)

  • Authors:
    • Noriko Nakano
    • Satoru Matsuda
    • Mayuko Ichimura
    • Akari Minami
    • Mako Ogino
    • Toshiyuki Murai
    • Yasuko Kitagishi
  • View Affiliations

  • Published online on: December 16, 2016     https://doi.org/10.3892/ijmm.2016.2833
  • Pages: 253-260
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Abstract

Parkinson's disease (PD) is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. Numerous pathological processes including, inflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalance, and apoptosis as well as genetic factors may lead to neuronal degeneration. Motor deficits in PD are due mostly to the progressive loss of nigrostriatal dopaminergic neurons. Neuroprotection of functional neurons is of significance in the treatment of PD. G protein‑coupled receptors (GPCRs) have been implicated in the neuroprotection against PD through the survival of dopaminergic neurons. In addition, phosphatidyl‑inositol‑3‑kinase (PI3K)/AKT signaling has also been demonstrated to be neuroprotective. Knowledge of the mechanisms involved in this cellular protection could be critical for developing treatments to prevent this neurodegenerative disorder. In this review, we highlight the protective roles of the PI3K/AKT signaling pathway in the function of representative serotonin GPCRs. Particular attention is given to the molecular mechanisms of this pathway proposed to explain the favorable effects of food ingredients against neurodegenerative disease.
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February-2017
Volume 39 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nakano N, Matsuda S, Ichimura M, Minami A, Ogino M, Murai T and Kitagishi Y: PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review). Int J Mol Med 39: 253-260, 2017
APA
Nakano, N., Matsuda, S., Ichimura, M., Minami, A., Ogino, M., Murai, T., & Kitagishi, Y. (2017). PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review). International Journal of Molecular Medicine, 39, 253-260. https://doi.org/10.3892/ijmm.2016.2833
MLA
Nakano, N., Matsuda, S., Ichimura, M., Minami, A., Ogino, M., Murai, T., Kitagishi, Y."PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review)". International Journal of Molecular Medicine 39.2 (2017): 253-260.
Chicago
Nakano, N., Matsuda, S., Ichimura, M., Minami, A., Ogino, M., Murai, T., Kitagishi, Y."PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review)". International Journal of Molecular Medicine 39, no. 2 (2017): 253-260. https://doi.org/10.3892/ijmm.2016.2833