Open Access

Human osteopontin: Potential clinical applications in cancer (Review)

  • Authors:
    • Chengcheng Hao
    • Yuxin Cui
    • Sionen Owen
    • Wenbin Li
    • Shan Cheng
    • Wen G. Jiang
  • View Affiliations

  • Published online on: April 21, 2017     https://doi.org/10.3892/ijmm.2017.2964
  • Pages: 1327-1337
  • Copyright : © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant expression of OPN is closely associated with tumourigensis, progression and most prominently with metastasis in several tumour types. In this review, we present the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. We also discuss its putative clinical application as a cancer biomarker and as a therapeutic target.
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June-2017
Volume 39 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Hao C, Cui Y, Owen S, Li W, Cheng S and Jiang WG: Human osteopontin: Potential clinical applications in cancer (Review). Int J Mol Med 39: 1327-1337, 2017
APA
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., & Jiang, W.G. (2017). Human osteopontin: Potential clinical applications in cancer (Review). International Journal of Molecular Medicine, 39, 1327-1337. https://doi.org/10.3892/ijmm.2017.2964
MLA
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., Jiang, W. G."Human osteopontin: Potential clinical applications in cancer (Review)". International Journal of Molecular Medicine 39.6 (2017): 1327-1337.
Chicago
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., Jiang, W. G."Human osteopontin: Potential clinical applications in cancer (Review)". International Journal of Molecular Medicine 39, no. 6 (2017): 1327-1337. https://doi.org/10.3892/ijmm.2017.2964