EXPRESSION OF SEX-HORMONE RECEPTORS AND CLINICOPATHOLOGICAL FINDINGS IN HEPATOCELLULAR-CARCINOMA
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- Published online on: June 1, 1994 https://doi.org/10.3892/ijo.4.6.1349
- Pages: 1349-1352
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Abstract
We studied the expresssion of estrogen (ER), progesterone (PgR), and androgen receptors (AR) in hepatocellular carcinoma (HCC) and found expression in (7/36), 3.2% (1/31), 16.7% (4/24) of cases, respectively. The expression of ER did not correlate with histological grade, tumor size, or stage of disease. On the other hand, all the patients with AR-positive tumors had stage IV disease, and only 25% of the patients with AR-negative tumors had stage IV disease. The survival was not influenced by the expression pattern of ER, however, the survival of the patients with AR-positive tumors tended to be worse than that of patients with AR-negative tumors. We suggest that the AR expression correlates better with poor outcome in HCC than the ER expression.