Open Access

Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review)

  • Authors:
    • Daniel Boda
    • Anca Oana Docea
    • Daniela Calina
    • Mihaela Adriana Ilie
    • Constantin Caruntu
    • Sabina Zurac
    • Monica Neagu
    • Carolina Constantin
    • Daciana Elena Branisteanu
    • Vlad Voiculescu
    • Charalampos Mamoulakis
    • George Tzanakakis
    • Demetrios A. Spandidos
    • Nikolaos Drakoulis
    • Aristides M. Tsatsakis
  • View Affiliations

  • Published online on: January 29, 2018     https://doi.org/10.3892/ijo.2018.4256
  • Pages: 637-655
  • Copyright: © Boda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human papilloma viruses (HPV) are a small group of non‑enveloped viruses belonging to the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles consist of a genome in the form of a circular double‑stranded DNA, encompassing eight open reading frames, as well as a non‑enveloped icosahedral capsid. HPV infection is considered the most common sexually transmitted disease in both sexes and is strongly implicated in the pathogenesis of different types of cancer. ‘High‑risk’ mucosal HPV types, predominantly types 16, 18, 31, 33 and 35, are associated with most cervical, penile, vulvar, vaginal, anal, oropharyngeal cancers and pre‑cancers. Screening for HPV is necessary for the prognosis and for determining treatment strategies for cancer. Novel HPV markers, including proteomic and genomic markers, as well as anti‑papillomavirus vaccines are currently available. The aim of this comprehensive review was to thoroughly present the updated information on virus development, cancer occurrence, treatment and prevention strategies, in an attempt to shed further light into the field, including novel research avenues.
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March-2018
Volume 52 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Boda D, Docea AO, Calina D, Ilie MA, Caruntu C, Zurac S, Neagu M, Constantin C, Branisteanu DE, Voiculescu V, Voiculescu V, et al: Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review). Int J Oncol 52: 637-655, 2018
APA
Boda, D., Docea, A.O., Calina, D., Ilie, M.A., Caruntu, C., Zurac, S. ... Tsatsakis, A.M. (2018). Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review). International Journal of Oncology, 52, 637-655. https://doi.org/10.3892/ijo.2018.4256
MLA
Boda, D., Docea, A. O., Calina, D., Ilie, M. A., Caruntu, C., Zurac, S., Neagu, M., Constantin, C., Branisteanu, D. E., Voiculescu, V., Mamoulakis, C., Tzanakakis, G., Spandidos, D. A., Drakoulis, N., Tsatsakis, A. M."Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review)". International Journal of Oncology 52.3 (2018): 637-655.
Chicago
Boda, D., Docea, A. O., Calina, D., Ilie, M. A., Caruntu, C., Zurac, S., Neagu, M., Constantin, C., Branisteanu, D. E., Voiculescu, V., Mamoulakis, C., Tzanakakis, G., Spandidos, D. A., Drakoulis, N., Tsatsakis, A. M."Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review)". International Journal of Oncology 52, no. 3 (2018): 637-655. https://doi.org/10.3892/ijo.2018.4256