Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma

  • Authors:
    • Zhanmeng Zhu
    • Zhe Chen
    • Chunlin Chen
    • Ziyi Yang
    • Weibo Xuan
    • Yahui Hou
    • Yunfei Zuo
    • Shuangyi Ren
  • View Affiliations

  • Published online on: October 29, 2013     https://doi.org/10.3892/mco.2013.208
  • Pages: 139-145
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Abstract

The aim of this study was to investigate tumor biomarker carbohydrate antigen 724 (CA724) in the serum of patients with carcinomas of the colon and rectum at various clinical stages. Serum was collected from 51 patients with colon carcinoma (CC) and 49 patients with rectal carcinoma (RC). CA724 levels were then measured in the different groups according to site, TNM classification, gender, age and metastastic status of the patients. The statistical significance of the differences between the groups was calculated by non‑parametric statistics (Mann‑Whitney and Kruskall‑Wallis tests). We observed a close association between the serum CA724 levels and tumor migration in colorectal carcinoma (CRC) and opposite variation tendencies of CA724 in the evolution of CC and RC. In conclusion, we identified a close association between the serum levels of CA724 and tumor migration in CRC. The opposite variation tendencies of CA724 in the different evolution groups of CC and RC may reflect the differences between these two types of cancer. The evaluation of serum CA724 may be of monitoring and and predictive value and may also assist in the development of treatment strategies for CRC patients.
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January-February 2014
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Spandidos Publications style
Zhu Z, Chen Z, Chen C, Yang Z, Xuan W, Hou Y, Zuo Y and Ren S: Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma. Mol Clin Oncol 2: 139-145, 2014
APA
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y. ... Ren, S. (2014). Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma. Molecular and Clinical Oncology, 2, 139-145. https://doi.org/10.3892/mco.2013.208
MLA
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y., Zuo, Y., Ren, S."Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma". Molecular and Clinical Oncology 2.1 (2014): 139-145.
Chicago
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y., Zuo, Y., Ren, S."Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma". Molecular and Clinical Oncology 2, no. 1 (2014): 139-145. https://doi.org/10.3892/mco.2013.208