Open Access

Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report

  • Authors:
    • Iosune Baraibar
    • Almudena Quílez
    • Diego Salas
    • Marta Román
    • Christian Rolfo
    • José L. Pérez-Gracia
    • Ignacio Gil-Bazo
  • View Affiliations

  • Published online on: April 6, 2017     https://doi.org/10.3892/mco.2017.1210
  • Pages: 651-654
  • Copyright: © Baraibar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The universal clinical use of multi-targeted tyrosine kinase inhibitors (TKIs) in patients diagnosed with advanced renal cell carcinoma (RCC) has significantly prolonged their estimated survival times and their quality of life. However, several adverse side-effects associated predominantly with the inhibition of the vascular endothelial growth factor receptor by these drugs may prove to be potentially life-threatening. One adverse event that is only rarely observed with the use of TKIs in this clinical setting is acute pancreatitis. In the present study, to the best of our knowledge, the first case of asymptomatic radiological acute pancreatitis associated with the use of pazopanib in monotherapy in a patient with RCC is presented. In addition, a comprehensive review of the literature on this topic is provided, and certain potential measures that may aid in early diagnosis and treatment are discussed.
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May-2017
Volume 6 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Baraibar I, Quílez A, Salas D, Román M, Rolfo C, Pérez-Gracia JL and Gil-Bazo I: Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report. Mol Clin Oncol 6: 651-654, 2017
APA
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J.L., & Gil-Bazo, I. (2017). Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report. Molecular and Clinical Oncology, 6, 651-654. https://doi.org/10.3892/mco.2017.1210
MLA
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J. L., Gil-Bazo, I."Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report". Molecular and Clinical Oncology 6.5 (2017): 651-654.
Chicago
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J. L., Gil-Bazo, I."Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report". Molecular and Clinical Oncology 6, no. 5 (2017): 651-654. https://doi.org/10.3892/mco.2017.1210