Bortezomib as a probable cause of the syndrome of inappropriate antidiuretic hormone secretion: A case report and review of the literature

  • Authors:
    • Cheng‑Lan Lv
    • Juan Li
  • View Affiliations

  • Published online on: August 7, 2017     https://doi.org/10.3892/mco.2017.1366
  • Pages: 667-672
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Abstract

Bortezomib is a proteasome inhibitor that has been widely adopted for the treatment of hematological malignancies, including multiple myeloma and lymphoma, and has been considered significantly more tolerable compared with traditional chemotherapeutic drugs. Bortezomib has some potential side effects that involve a number of systems, including the gastrointestinal, hematological, nervous and musculoskeletal systems; however, involvement of the endocrine system is rare. We herein report the case of a patient treated for multiple myeloma who developed the syndrome of inappropriate antidiuretic hormone secretion after bortezomib was added to his chemotherapy regimen. Following treatment with an infusion of hypertonic saline and fluid restriction for >2 months, the serum sodium level gradually recovered.
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October-2017
Volume 7 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Lv CL and Lv CL: Bortezomib as a probable cause of the syndrome of inappropriate antidiuretic hormone secretion: A case report and review of the literature. Mol Clin Oncol 7: 667-672, 2017
APA
Lv, C., & Lv, C. (2017). Bortezomib as a probable cause of the syndrome of inappropriate antidiuretic hormone secretion: A case report and review of the literature. Molecular and Clinical Oncology, 7, 667-672. https://doi.org/10.3892/mco.2017.1366
MLA
Lv, C., Li, J."Bortezomib as a probable cause of the syndrome of inappropriate antidiuretic hormone secretion: A case report and review of the literature". Molecular and Clinical Oncology 7.4 (2017): 667-672.
Chicago
Lv, C., Li, J."Bortezomib as a probable cause of the syndrome of inappropriate antidiuretic hormone secretion: A case report and review of the literature". Molecular and Clinical Oncology 7, no. 4 (2017): 667-672. https://doi.org/10.3892/mco.2017.1366