Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma

  • Authors:
    • Ku Jung Kwon
    • Seunghee Bae
    • Karam Kim
    • In Sook An
    • Kyu Joong Ahn
    • Sungkwan An
    • Hwa Jun Cha
  • View Affiliations

  • Published online on: April 16, 2014     https://doi.org/10.3892/mmr.2014.2159
  • Pages: 503-507
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Abstract

Melanogenesis is the process of generating pigmentation via melanin synthesis and delivery. Three key enzymes, tyrosinase, tyrosinase‑related protein 1 (TRP1) and TRP2, metabolize melanin from L‑tyrosine. Melanin synthesizing enzymes are regulated by microphthalmia‑associated transcription factor (MITF). The titrated extract of Centella asiatica (TECA) contains the major components asiatic acid, asiaticoside and madecassic acid. The present study revealed that TECA reduces the melanin content in melanocytes. Moreover, the asiaticoside contained in TECA modulated melanogenesis by inhibiting tyrosinase mRNA expression. The decrease in tyrosinase mRNA levels was mediated through MITF. Uniquely, asiaticoside inhibited MITF by decreasing its DNA binding affinity. In conclusion, the results of the present study indicate that asiaticoside treatment may have beneficial effects in hyperpigmentation diseases or for skin whitening.
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July-2014
Volume 10 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Kwon KJ, Bae S, Kim K, An IS, Ahn KJ, An S and Cha HJ: Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma. Mol Med Rep 10: 503-507, 2014
APA
Kwon, K.J., Bae, S., Kim, K., An, I.S., Ahn, K.J., An, S., & Cha, H.J. (2014). Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma. Molecular Medicine Reports, 10, 503-507. https://doi.org/10.3892/mmr.2014.2159
MLA
Kwon, K. J., Bae, S., Kim, K., An, I. S., Ahn, K. J., An, S., Cha, H. J."Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma". Molecular Medicine Reports 10.1 (2014): 503-507.
Chicago
Kwon, K. J., Bae, S., Kim, K., An, I. S., Ahn, K. J., An, S., Cha, H. J."Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma". Molecular Medicine Reports 10, no. 1 (2014): 503-507. https://doi.org/10.3892/mmr.2014.2159