Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury

  • Authors:
    • Ye Cai
    • Hui Xu
    • Jia Yan
    • Lei Zhang
    • Yi Lu
  • View Affiliations

  • Published online on: March 10, 2014     https://doi.org/10.3892/mmr.2014.2034
  • Pages: 1542-1550
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Abstract

Dexmedetomidine (DEX), a highly specific α2‑adrenergic agonist, which exhibits anaesthetic‑sparing, analgesia and sympatholytic properties. DEX modulates gene expression, channel activation, transmitter release, inflammatory processes and apoptotic and necrotic cell death. It has also been demonstrated to have protective effects in a variety of animal models of ischemia/reperfusion (I/R) injury, including the intestine, myocardial, renal, lung, cerebral and liver. The broad spectrum of biological activities associated with DEX continues to expand, and its diverse effects suggest that it may offer a novel therapeutic approach for the treatment of human diseases with I/R involvement.
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May-2014
Volume 9 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Cai Y, Xu H, Yan J, Zhang L and Lu Y: Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury. Mol Med Rep 9: 1542-1550, 2014
APA
Cai, Y., Xu, H., Yan, J., Zhang, L., & Lu, Y. (2014). Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury. Molecular Medicine Reports, 9, 1542-1550. https://doi.org/10.3892/mmr.2014.2034
MLA
Cai, Y., Xu, H., Yan, J., Zhang, L., Lu, Y."Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury". Molecular Medicine Reports 9.5 (2014): 1542-1550.
Chicago
Cai, Y., Xu, H., Yan, J., Zhang, L., Lu, Y."Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury". Molecular Medicine Reports 9, no. 5 (2014): 1542-1550. https://doi.org/10.3892/mmr.2014.2034