Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway

  • Authors:
    • Jinghua Wu
    • Jiapei Guo
    • Qing Cao
    • Yi Wang
    • Junmao Chen
    • Zhigang Wang
    • Zhiyong Yuan
  • View Affiliations

  • Published online on: December 8, 2016     https://doi.org/10.3892/ol.2016.5476
  • Pages: 770-776
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Abstract

The interleukin (IL)-17/IL-17 receptor (IL-17R) complex has been shown to be important for the regulation of inflammation; however, its role in the regulation of tumor processes has recently emerged as a research focus. The present study demonstrated that oxaliplatin was able to increase the levels of IL‑17/IL‑17R in hepatocellular carcinoma (HCC) patients and cells lines, and that it had important roles in reducing the susceptibility of the cells to oxaliplatin‑induced apoptosis. Furthermore, the expression of autophagy‑related proteins was induced by IL-17/IL-17R and autophagy was shown to induce resistance to oxaliplatin in HCC. In addition, the janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway was shown to be an important pathway in the induction of autophagy in response to oxaliplatin. Autopjhagy was inhibited by 3-methyladenine and JAK2/STAT3 signaling was blocked by AG490, which induced apoptosis in SMMC7721 cells treated with oxaliplatin. The results of the present study may help to elucidate the mechanism underlying the role of IL‑17/IL‑17R‑induced autophagy in the chemoresistance of HCC, as well as help to establish and develop measures to overcome chemoresistance in HCC.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wu J, Guo J, Cao Q, Wang Y, Chen J, Wang Z and Yuan Z: Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway. Oncol Lett 13: 770-776, 2017
APA
Wu, J., Guo, J., Cao, Q., Wang, Y., Chen, J., Wang, Z., & Yuan, Z. (2017). Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway. Oncology Letters, 13, 770-776. https://doi.org/10.3892/ol.2016.5476
MLA
Wu, J., Guo, J., Cao, Q., Wang, Y., Chen, J., Wang, Z., Yuan, Z."Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway". Oncology Letters 13.2 (2017): 770-776.
Chicago
Wu, J., Guo, J., Cao, Q., Wang, Y., Chen, J., Wang, Z., Yuan, Z."Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway". Oncology Letters 13, no. 2 (2017): 770-776. https://doi.org/10.3892/ol.2016.5476