MicroRNA‑149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility

  • Authors:
    • Jingxin Chen
    • Jimin Chen
    • Weizhong Li
  • View Affiliations

  • Published online on: December 20, 2016     https://doi.org/10.3892/ol.2016.5527
  • Pages: 851-856
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Abstract

The expression and function of microRNA-149 have been studied in numerous types of cancer. However, thus far, there are no studies of microRNA‑149 in tongue squamous cell carcinoma (TSCC). The present study investigated the expression, biological function and molecular mechanism of microRNA‑149 in TSCC in vitro, discussing whether it may be a therapeutic biomarker of TSCC in the future. In the present study, microRNA‑149 expression in TSCC tissues, matched normal adjacent tissues, TSCC cell lines and normal gingival epithelial cells were analyzed using quantitative polymerase chain reaction. Following transfection with microRNA‑149 mimics, cell proliferation, migration and invasion assays, a luciferase assay and western blotting were performed. The present study found that the expression of microRNA‑149 was significantly decreased in TSCC tissues and cell lines compared with matched normal tissue and normal gingival epithelial cells, respectively. In addition, it was also demonstrated that microRNA‑149 inhibited cell proliferation, migration and invasion by directly targeting specificity protein 1. Therefore, the results suggested that microRNA‑149 may be a novel target for TSCC therapy in the future.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen J, Chen J and Li W: MicroRNA‑149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility. Oncol Lett 13: 851-856, 2017
APA
Chen, J., Chen, J., & Li, W. (2017). MicroRNA‑149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility. Oncology Letters, 13, 851-856. https://doi.org/10.3892/ol.2016.5527
MLA
Chen, J., Chen, J., Li, W."MicroRNA‑149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility". Oncology Letters 13.2 (2017): 851-856.
Chicago
Chen, J., Chen, J., Li, W."MicroRNA‑149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility". Oncology Letters 13, no. 2 (2017): 851-856. https://doi.org/10.3892/ol.2016.5527