Open Access

Reconstruction of mandibular defects with autogenous bone and decellularized bovine bone grafts with freeze‑dried bone marrow stem cell paracrine factors

  • Authors:
    • Ann Kakabadze
    • Konstantine Mardaleishvili
    • George Loladze
    • Lia Karalashvili
    • Gocha Chutkerashvili
    • David Chakhunashvili
    • Zurab Kakabadze
  • View Affiliations

  • Published online on: January 25, 2017     https://doi.org/10.3892/ol.2017.5647
  • Pages: 1811-1818
  • Copyright: © Kakabadze et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The gold standard following segmental mandibulectomy is vascularized autologous bone graft in the form of the fibula flap. However, in bone reconstruction the use of autogenous bone does not always guarantee a successful outcome. The aim of the present investigation was to develop a novel biologically active bone (BAB) graft, and to use it for the reconstruction of large size defects of the mandible bone following tumor resection. In the first part of the present study, biologically active bone graft was developed by using human freeze‑dried bone marrow stem cells (BMSCs) paracrine factors and three‑dimensional bone scaffold derived from cancellous bovine bone following decellularization. In the second part of the research, one male and three female patients with primary tumors of the mandible underwent hemimandibulectomy. The mandibular bone defects following tumor resection were reconstructed with autogenous rib grafts in three patients and BAB graft was used in one patient. The graft‑host interfaces were covered with decellularized human amnion/chorion membrane graft. All patients were followed‑up every five months following the reconstruction of the mandible, with no complications observed. Preliminary clinical investigations demonstrated that a BAB graft containing freeze‑dried BMSC paracrine factors may be used for the reconstruction of large mandibular bone defects following tumor resection.
View Figures
View References

Related Articles

Journal Cover

March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kakabadze A, Mardaleishvili K, Loladze G, Karalashvili L, Chutkerashvili G, Chakhunashvili D and Kakabadze Z: Reconstruction of mandibular defects with autogenous bone and decellularized bovine bone grafts with freeze‑dried bone marrow stem cell paracrine factors. Oncol Lett 13: 1811-1818, 2017
APA
Kakabadze, A., Mardaleishvili, K., Loladze, G., Karalashvili, L., Chutkerashvili, G., Chakhunashvili, D., & Kakabadze, Z. (2017). Reconstruction of mandibular defects with autogenous bone and decellularized bovine bone grafts with freeze‑dried bone marrow stem cell paracrine factors. Oncology Letters, 13, 1811-1818. https://doi.org/10.3892/ol.2017.5647
MLA
Kakabadze, A., Mardaleishvili, K., Loladze, G., Karalashvili, L., Chutkerashvili, G., Chakhunashvili, D., Kakabadze, Z."Reconstruction of mandibular defects with autogenous bone and decellularized bovine bone grafts with freeze‑dried bone marrow stem cell paracrine factors". Oncology Letters 13.3 (2017): 1811-1818.
Chicago
Kakabadze, A., Mardaleishvili, K., Loladze, G., Karalashvili, L., Chutkerashvili, G., Chakhunashvili, D., Kakabadze, Z."Reconstruction of mandibular defects with autogenous bone and decellularized bovine bone grafts with freeze‑dried bone marrow stem cell paracrine factors". Oncology Letters 13, no. 3 (2017): 1811-1818. https://doi.org/10.3892/ol.2017.5647