High IL-17 expression is associated with an unfavorable prognosis in thyroid cancer

  • Authors:
    • Denise Faria Galano Carvalho
    • Bruna Riedo Zanetti
    • Lydianne Miranda
    • Marcela Kazue Hassumi‑Fukasawa
    • Fabiana Miranda‑Camargo
    • Janaína Cristiana Oliveira Crispim
    • Edson Garcia Soares
  • View Affiliations

  • Published online on: January 25, 2017     https://doi.org/10.3892/ol.2017.5638
  • Pages: 1925-1931
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Abstract

Previous studies have indicated that cancer may be promoted and/or exacerbated by inflammation and infection. The cytokines produced by activated innate immune cells that stimulate tumor growth and progression are considered as important components in this process. The interleukin (IL)‑23/T helper (Th)17 axis, which exerts marked pro‑inflammatory effects, has emerged as an important mediator in inflammation‑associated cancer. Increasing clinical evidence indicates that Th17 may promote or inhibit tumor progression, however, the function of Th17 in the pathogenesis of benign and malignant thyroid neoplasms remains unclear. The present study investigated the association between the IL‑23/Th17 axis and neoplastic and non‑neoplastic thyroid lesions using immunohistochemistry. A total of 131 thyroid biopsy specimens were analyzed, which revealed high IL‑17 and IL‑23 expression in differentiated thyroid cancer and medullary thyroid cancer tissues when compared with benign lesions, including follicular thyroid adenoma and goiter tissues. Furthermore, high IL‑17 expression was associated with recurrence and mortality. These results indicate that the IL‑23/Th17 axis exhibits a pivotal function in the development of thyroid neoplasms.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Galano Carvalho DF, Zanetti BR, Miranda L, Hassumi‑Fukasawa MK, Miranda‑Camargo F, Crispim JC and Soares EG: High IL-17 expression is associated with an unfavorable prognosis in thyroid cancer. Oncol Lett 13: 1925-1931, 2017
APA
Galano Carvalho, D.F., Zanetti, B.R., Miranda, L., Hassumi‑Fukasawa, M.K., Miranda‑Camargo, F., Crispim, J.C., & Soares, E.G. (2017). High IL-17 expression is associated with an unfavorable prognosis in thyroid cancer. Oncology Letters, 13, 1925-1931. https://doi.org/10.3892/ol.2017.5638
MLA
Galano Carvalho, D. F., Zanetti, B. R., Miranda, L., Hassumi‑Fukasawa, M. K., Miranda‑Camargo, F., Crispim, J. C., Soares, E. G."High IL-17 expression is associated with an unfavorable prognosis in thyroid cancer". Oncology Letters 13.3 (2017): 1925-1931.
Chicago
Galano Carvalho, D. F., Zanetti, B. R., Miranda, L., Hassumi‑Fukasawa, M. K., Miranda‑Camargo, F., Crispim, J. C., Soares, E. G."High IL-17 expression is associated with an unfavorable prognosis in thyroid cancer". Oncology Letters 13, no. 3 (2017): 1925-1931. https://doi.org/10.3892/ol.2017.5638