Open Access

Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer

  • Authors:
    • Yuexing Lai
    • Ping Xu
    • Jie Liu
    • Qinghua Li
    • Dabin Ren
    • Jun Zhang
    • Jing Wang
  • View Affiliations

  • Published online on: June 23, 2017     https://doi.org/10.3892/ol.2017.6478
  • Pages: 2629-2634
  • Copyright: © Lai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In recent years, the identification of long non-coding RNAs (lncRNAs) led to the analysis of their characteristics in cancer biology. However, the expression of lncRNAs in cancer and their clinical significance remain unclear. In the present study, an investigation of lncRNAs that may be involved in the regulation of metastasis using microarray and polymerase chain reaction analyses resulted in the identification of MLLT4 antisense RNA 1 (MLLT4‑AS1) as a significantly downregulated lncRNA in gastric cancer tissue compared with normal adjacent tissue (P=0.006). Furthermore, the downregulation of MLL4‑AS1 was significantly associated with advanced Tumor‑Node‑Metastasis stage (P=0.007) and lymph node metastasis (P=0.008). Cox regression analysis showed that MLLT4-AS1 expression was an independent predictor for overall survival (hazard ratio, 13.136; 95% confidence interval, 5.065-34.068; P<0.001). These data suggest that the decreased expression of MLLT4‑AS1 is a potential biomarker and a predictor of a poor prognosis for gastric cancer.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lai Y, Xu P, Liu J, Li Q, Ren D, Zhang J and Wang J: Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer. Oncol Lett 14: 2629-2634, 2017
APA
Lai, Y., Xu, P., Liu, J., Li, Q., Ren, D., Zhang, J., & Wang, J. (2017). Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer. Oncology Letters, 14, 2629-2634. https://doi.org/10.3892/ol.2017.6478
MLA
Lai, Y., Xu, P., Liu, J., Li, Q., Ren, D., Zhang, J., Wang, J."Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer". Oncology Letters 14.3 (2017): 2629-2634.
Chicago
Lai, Y., Xu, P., Liu, J., Li, Q., Ren, D., Zhang, J., Wang, J."Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer". Oncology Letters 14, no. 3 (2017): 2629-2634. https://doi.org/10.3892/ol.2017.6478