Dysregulation of signaling pathways and putative biomarkers in liver cancer stem cells (Review)

  • Authors:
    • Kai Song
    • Junhua Wu
    • Chunping Jiang
  • View Affiliations

  • Published online on: October 17, 2012     https://doi.org/10.3892/or.2012.2082
  • Pages: 3-12
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hepatocellular carcinoma (HCC) is one of the most common tumors in the world. At present, the details of the mechanism responsible for HCC formation and maintenance remain unclear. However, the cancer stem cell (CSC) theory suggests that liver cancer stem cells (LCSCs) may be responsible for the biological characteristics of HCC. Dysregulation of signaling pathways, including transforming growth factor β (TGF-β), Wnt, Notch and Hedgehog pathways, has been found to be involved in the process of hepatocarcinogenesis and is considered the key determinant of LCSC function. Numerous LCSC biomarkers have been identified including CD133, epithelial cell adhesion molecule (EpCAM), ABCG2 and CD90, which would contribute to the isolation of LCSCs.
View Figures
View References

Related Articles

Journal Cover

January 2013
Volume 29 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Song K, Wu J and Jiang C: Dysregulation of signaling pathways and putative biomarkers in liver cancer stem cells (Review). Oncol Rep 29: 3-12, 2013
APA
Song, K., Wu, J., & Jiang, C. (2013). Dysregulation of signaling pathways and putative biomarkers in liver cancer stem cells (Review). Oncology Reports, 29, 3-12. https://doi.org/10.3892/or.2012.2082
MLA
Song, K., Wu, J., Jiang, C."Dysregulation of signaling pathways and putative biomarkers in liver cancer stem cells (Review)". Oncology Reports 29.1 (2013): 3-12.
Chicago
Song, K., Wu, J., Jiang, C."Dysregulation of signaling pathways and putative biomarkers in liver cancer stem cells (Review)". Oncology Reports 29, no. 1 (2013): 3-12. https://doi.org/10.3892/or.2012.2082