Open Access

Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation

  • Authors:
    • Zhizhen Liu
    • Lianming Liao
    • Zhiyun Cao
    • Xuzheng Chen
    • Jian Du
  • View Affiliations

  • Published online on: December 28, 2016     https://doi.org/10.3892/or.2016.5339
  • Pages: 754-760
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It is well documented that A proliferation-inducing ligand (APRIL), a member of the tumor necrosis factor superfamily, plays a crucial role in the occurrence and development of tumors. In the present study, we evaluated the synergistic effect of APRIL knockdown and Jiedu Xiaozheng Yin (JXY), a Traditional Chinese Medicinal recipe, on the inhibition of hepatocellular carcinoma (HCC) cell proliferation and elucidated the underlying mechanism. The results demonstrated that both APRIL knockdown using small interfering RNA (siRNA) and JXY treatment could trigger cell cycle arrest and cell apoptosis, and suppress HCC cell proliferation through an NF-κB-related pathway. Synergism was further demonstrated between APRIL knockdown and JXY treatment. In conclusion, these results indicate that APRIL is a target gene for HCC and combination of siRNA-APRIL and JXY application holds great promise as a novel approach for the treatment of APRIL-positive HCC.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Z, Liao L, Cao Z, Chen X and Du J: Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation. Oncol Rep 37: 754-760, 2017
APA
Liu, Z., Liao, L., Cao, Z., Chen, X., & Du, J. (2017). Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation. Oncology Reports, 37, 754-760. https://doi.org/10.3892/or.2016.5339
MLA
Liu, Z., Liao, L., Cao, Z., Chen, X., Du, J."Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation". Oncology Reports 37.2 (2017): 754-760.
Chicago
Liu, Z., Liao, L., Cao, Z., Chen, X., Du, J."Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation". Oncology Reports 37, no. 2 (2017): 754-760. https://doi.org/10.3892/or.2016.5339