Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90β

  • Authors:
    • Sai Li
    • Jincheng Li
    • Tian Hu
    • Chuhong Zhang
    • Xiu Lv
    • Sha He
    • Hanxing Yan
    • Yixi Tan
    • Meiling Wen
    • Mingsheng Lei
    • Jianhong Zuo
  • View Affiliations

  • Published online on: December 7, 2016     https://doi.org/10.3892/or.2016.5295
  • Pages: 849-856
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Abstract

Laryngeal carcinoma (LC) is one of the most common malignant tumors of all head and neck squamous cell carcinomas (HNSCCs). However, the molecular mechanism and genetic basis of the development of LC have not been fully elucidated. To explore the possible mechanism, targeted proteomic analysis was performed on Bcl-2-associated proteins from LC cells. According to our results, 35 proteins associated with Bcl-2 were identified and Hsp90β was confirmed by co-immunoprecipitation and western blot analysis. Protein‑protein interaction (PPI) analysis indicated that Bcl-2‑Hsp90β interactions may be involved in the anti-apoptotic progression of LC. Further results revealed that disruption of the Bcl-2-Hsp90β interaction inhibited the anti-apoptotic ability of Bcl-2 and decreased the caspase activation in LC, which has broad implications for the better understanding of tumor formation, tumor cell survival and development of metastasis due to Bcl-2. Collectively, we report the mechanism by which Bcl-2 functions in LC as an anti-apoptotic factor in relation to its association with proteins and potentially identify a Bcl-2/Hsp90β axis as a novel target for LC therapy.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li S, Li J, Hu T, Zhang C, Lv X, He S, Yan H, Tan Y, Wen M, Lei M, Lei M, et al: Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90β. Oncol Rep 37: 849-856, 2017
APA
Li, S., Li, J., Hu, T., Zhang, C., Lv, X., He, S. ... Zuo, J. (2017). Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90β. Oncology Reports, 37, 849-856. https://doi.org/10.3892/or.2016.5295
MLA
Li, S., Li, J., Hu, T., Zhang, C., Lv, X., He, S., Yan, H., Tan, Y., Wen, M., Lei, M., Zuo, J."Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90β". Oncology Reports 37.2 (2017): 849-856.
Chicago
Li, S., Li, J., Hu, T., Zhang, C., Lv, X., He, S., Yan, H., Tan, Y., Wen, M., Lei, M., Zuo, J."Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90β". Oncology Reports 37, no. 2 (2017): 849-856. https://doi.org/10.3892/or.2016.5295