Autocrine motility factor receptor gene expression and cell motility in lung cancer cell lines

  • Authors:
    • I. Takanami
    • K. Takeuchi
    • H. Watanabe
    • T. Yanagawa
    • K. Takagishi
  • View Affiliations

  • Published online on: January 1, 2002     https://doi.org/10.3892/or.9.1.125
  • Pages: 125-128
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Abstract

The cell motility of tumor cells is an integral component of tumor invasion and metastasis. Autocrine motility factor (AMF) stimulates cell motility via a receptor (R)-mediated signal pathway. We studied the correlation between level of AMF-R gene expression by reverse transcription-polymerase chain reaction and cell motility by phagokinetic track assay with or without AMF in lung cancer cell lines. Lung cancer cell lines with higher AMF-R gene expression tended to have greater cell motility than those with lower AMF-R gene expression with or without AMF. Most of lung cancer cell lines showed significantly increased motility with the stimulation of AMF. We conclude that the presence of higher AMF-R gene expression and tumor cell motility via receptor in response to the stimulation of AMF could be an important aspect in the invasion and metastasis of lung cancer cell lines.

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January-February 2002
Volume 9 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Takanami I, Takeuchi K, Watanabe H, Yanagawa T and Takagishi K: Autocrine motility factor receptor gene expression and cell motility in lung cancer cell lines. Oncol Rep 9: 125-128, 2002.
APA
Takanami, I., Takeuchi, K., Watanabe, H., Yanagawa, T., & Takagishi, K. (2002). Autocrine motility factor receptor gene expression and cell motility in lung cancer cell lines. Oncology Reports, 9, 125-128. https://doi.org/10.3892/or.9.1.125
MLA
Takanami, I., Takeuchi, K., Watanabe, H., Yanagawa, T., Takagishi, K."Autocrine motility factor receptor gene expression and cell motility in lung cancer cell lines". Oncology Reports 9.1 (2002): 125-128.
Chicago
Takanami, I., Takeuchi, K., Watanabe, H., Yanagawa, T., Takagishi, K."Autocrine motility factor receptor gene expression and cell motility in lung cancer cell lines". Oncology Reports 9, no. 1 (2002): 125-128. https://doi.org/10.3892/or.9.1.125