Open Access

Effectiveness and safety of immune response to SARS‑CoV‑2 vaccine in patients with chronic kidney disease and dialysis: A systematic review and meta‑analysis

  • Authors:
    • Kejia Li
    • Yang Xia
    • Hua Ye
    • Xian Sun
    • Bairu Shi
    • Jiajun Wu
  • View Affiliations

  • Published online on: March 19, 2024     https://doi.org/10.3892/br.2024.1766
  • Article Number: 78
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The coronavirus disease 2019 (COVID‑19) vaccination is the most effective way to prevent COVID‑19. However, for chronic kidney disease patients on long‑term dialysis, there is a lack of evidence regarding the efficacy and safety of the immune response to the vaccine. The present meta‑analysis explores the efficacy and safety of COVID‑19 vaccine in the immune response of patients with chronic kidney disease (CKD) undergoing dialysis. PubMed, Web of Science, Science Direct, and Cochrane Library databases were systematically searched from January 1, 2020, to December 31, 2022. Data analysis was performed using REVMAN 5.1s and Stata14 software. Baseline data and endpoint events were extracted, mainly including age, sex, dialysis vintage, body mass index (BMI), vaccine type and dose, history of COVID‑19 infection, seropositivity rate, antibody titer, pain at injection site, headache and other safety events. The meta‑analysis included 33 trials involving 81,348 patients. The immune efficacy of patients with CKD and dialysis was 80% (95 CI, 73‑87%). The seropositivity rate of individuals without COVID‑19 infection was 76.48% (3,824/5,000), while the seropositivity rate of individuals with COVID‑19 infection was 80.82% (1,858/2,299). The standard mean difference of antibody titers in CKD and dialysis patients with or without COVID‑19 infection was 27.73 (95% CI, ‑19.58‑75.04). A total of nine studies reported the most common adverse events: Pain at the injection site, accounting for 18% (95 CI, 6‑29%), followed by fatigue and headache, accounting for 8 (95 CI, 4‑13%) and 6% (95 CI, 2‑9%), respectively. COVID‑19 vaccine benefitted patients with CKD undergoing dialysis with seropositivity rate ≥80%. Adverse events such as fatigue, headache, and pain at the injection site may occur after COVID‑19 vaccination but the incidence is low. 
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May-2024
Volume 20 Issue 5

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Spandidos Publications style
Li K, Xia Y, Ye H, Sun X, Shi B and Wu J: Effectiveness and safety of immune response to SARS‑CoV‑2 vaccine in patients with chronic kidney disease and dialysis: A systematic review and meta‑analysis. Biomed Rep 20: 78, 2024
APA
Li, K., Xia, Y., Ye, H., Sun, X., Shi, B., & Wu, J. (2024). Effectiveness and safety of immune response to SARS‑CoV‑2 vaccine in patients with chronic kidney disease and dialysis: A systematic review and meta‑analysis. Biomedical Reports, 20, 78. https://doi.org/10.3892/br.2024.1766
MLA
Li, K., Xia, Y., Ye, H., Sun, X., Shi, B., Wu, J."Effectiveness and safety of immune response to SARS‑CoV‑2 vaccine in patients with chronic kidney disease and dialysis: A systematic review and meta‑analysis". Biomedical Reports 20.5 (2024): 78.
Chicago
Li, K., Xia, Y., Ye, H., Sun, X., Shi, B., Wu, J."Effectiveness and safety of immune response to SARS‑CoV‑2 vaccine in patients with chronic kidney disease and dialysis: A systematic review and meta‑analysis". Biomedical Reports 20, no. 5 (2024): 78. https://doi.org/10.3892/br.2024.1766