NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression
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- Published online on: August 1, 2001 https://doi.org/10.3892/ijmm.8.2.181
- Pages: 181-182
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Abstract
NC-1500 is a dihydropyridine type calcium channel blocker. The effect of NC-1500 on mice concanavalin A-induced hepatitis was examined. Treatment of mice with concanavalin A (Con A) caused elevation of plasma transaminase. Pretreatment of mice with NC-1500 (3, 10 and 30 mg/kg, p.o.) prevented this Con A-induced elevation of plasma transaminase. Treatment of mice with Con A induced tumor necrosis factor-α (TNF-α) mRNA expression in the liver. However, NC-1500 (30 mg/kg, p.o.) did not affect this Con A-induced TNF-α mRNA expression in the liver. The present results showed that NC-1500 inhibited Con A-induced hepatitis without affecting TNF-α mRNA expression in the liver.
