NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression

  • Authors:
    • Toshihiro Okamoto
    • Tadashi Kobayashi
    • Seon-Yong Jeong
  • View Affiliations

  • Published online on: August 1, 2001     https://doi.org/10.3892/ijmm.8.2.181
  • Pages: 181-182
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

NC-1500 is a dihydropyridine type calcium channel blocker. The effect of NC-1500 on mice concanavalin A-induced hepatitis was examined. Treatment of mice with concanavalin A (Con A) caused elevation of plasma transaminase. Pretreatment of mice with NC-1500 (3, 10 and 30 mg/kg, p.o.) prevented this Con A-induced elevation of plasma transaminase. Treatment of mice with Con A induced tumor necrosis factor-α (TNF-α) mRNA expression in the liver. However, NC-1500 (30 mg/kg, p.o.) did not affect this Con A-induced TNF-α mRNA expression in the liver. The present results showed that NC-1500 inhibited Con A-induced hepatitis without affecting TNF-α mRNA expression in the liver.

Related Articles

Journal Cover

August 2001
Volume 8 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Okamoto T, Kobayashi T and Jeong S: NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression. Int J Mol Med 8: 181-182, 2001.
APA
Okamoto, T., Kobayashi, T., & Jeong, S. (2001). NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression. International Journal of Molecular Medicine, 8, 181-182. https://doi.org/10.3892/ijmm.8.2.181
MLA
Okamoto, T., Kobayashi, T., Jeong, S."NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression". International Journal of Molecular Medicine 8.2 (2001): 181-182.
Chicago
Okamoto, T., Kobayashi, T., Jeong, S."NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression". International Journal of Molecular Medicine 8, no. 2 (2001): 181-182. https://doi.org/10.3892/ijmm.8.2.181