Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis

  • Authors:
    • Kiminori Matsubara
    • Tomoko Kayashima
    • Masaharu Mori
    • Hiromi Yoshida
    • Yoshiyuki Mizushina
  • View Affiliations

  • Published online on: September 1, 2008     https://doi.org/10.3892/ijmm_00000034
  • Pages: 381-387
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Vitamins play essential roles in cellular reactions and maintain human health. Recent studies have revealed that some vitamins including D3, B6 and K2 and their derivatives have an anti-cancer effect. As a mechanism, their inhibitory effect on cancer-related angiogenesis has been demonstrated. Vitamin K2 (menaquinones) has an anti-cancer effect in particular for hepatic cancer and inhibits angiogenesis. In the current study, we demonstrated that sole vitamin K3 (menadione) selectively inhibits the in vitro activity of eukaryotic DNA polymerase γ, which is a mitochondrial DNA polymerase, and suppresses angiogenesis in a rat aortic ring model. The anti-angiogenic effect of vitamin K3 has been shown in angiogenesis models using human umbilical vein endothelial cells (HUVECs) with regard to HUVEC growth, tube formation on reconstituted basement membrane and chemotaxis. These results suggest that vitamin K3 may be a potential anti-cancer agent like vitamin K2.

Related Articles

Journal Cover

September 2008
Volume 22 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Matsubara K, Kayashima T, Mori M, Yoshida H and Mizushina Y: Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis. Int J Mol Med 22: 381-387, 2008.
APA
Matsubara, K., Kayashima, T., Mori, M., Yoshida, H., & Mizushina, Y. (2008). Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis. International Journal of Molecular Medicine, 22, 381-387. https://doi.org/10.3892/ijmm_00000034
MLA
Matsubara, K., Kayashima, T., Mori, M., Yoshida, H., Mizushina, Y."Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis". International Journal of Molecular Medicine 22.3 (2008): 381-387.
Chicago
Matsubara, K., Kayashima, T., Mori, M., Yoshida, H., Mizushina, Y."Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis". International Journal of Molecular Medicine 22, no. 3 (2008): 381-387. https://doi.org/10.3892/ijmm_00000034