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Cytogenetic and CGH studies of four neuroendocrine tumors and tumor-derived cell lines of a patient with multiple endocrine neoplasia type 1.

  • Authors:
    • E Sigl
    • A Behmel
    • T Henn
    • G Wirnsberger
    • A Weinhausl
    • K Kaserer
    • B Niederle
    • R Pfragner

  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/ijo.15.1.41
  • Pages: 41-92
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Abstract

A malignant insulinoma (LOHG-I), a carcinoid of the lung (LOHG-L), a parathyroid adenoma (LOHG-NSA), and a fibroma (LOHG-F) were obtained from a patient with multiple endocrine neoplasia type 1 (MEN1). Long-term cultures were established. Essential neurobiological properties of the cell lines were proven immunocytochemically and by electron microscopy. Molecular analysis of the germline DNA showed a 4 bp deletion in exon 3 of the MEN1 gene. Cytogenetic and CGH analyses of the tumors/tumor cell lines revealed diploidy and balanced and unbalanced structural aberrations different for each tumor. Chromosomes 6q21, 11q and 17q were most frequently involved in clonal structural aberrations.

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Journal Cover

Jul 1999
Volume 15 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Sigl E, Behmel A, Henn T, Wirnsberger G, Weinhausl A, Kaserer K, Niederle B and Pfragner R: Cytogenetic and CGH studies of four neuroendocrine tumors and tumor-derived cell lines of a patient with multiple endocrine neoplasia type 1.. Int J Oncol 15: 41-92, 1999
APA
Sigl, E., Behmel, A., Henn, T., Wirnsberger, G., Weinhausl, A., Kaserer, K. ... Pfragner, R. (1999). Cytogenetic and CGH studies of four neuroendocrine tumors and tumor-derived cell lines of a patient with multiple endocrine neoplasia type 1.. International Journal of Oncology, 15, 41-92. https://doi.org/10.3892/ijo.15.1.41
MLA
Sigl, E., Behmel, A., Henn, T., Wirnsberger, G., Weinhausl, A., Kaserer, K., Niederle, B., Pfragner, R."Cytogenetic and CGH studies of four neuroendocrine tumors and tumor-derived cell lines of a patient with multiple endocrine neoplasia type 1.". International Journal of Oncology 15.1 (1999): 41-92.
Chicago
Sigl, E., Behmel, A., Henn, T., Wirnsberger, G., Weinhausl, A., Kaserer, K., Niederle, B., Pfragner, R."Cytogenetic and CGH studies of four neuroendocrine tumors and tumor-derived cell lines of a patient with multiple endocrine neoplasia type 1.". International Journal of Oncology 15, no. 1 (1999): 41-92. https://doi.org/10.3892/ijo.15.1.41