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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2005 Volume 27 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2005 Volume 27 Issue 3

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Article

Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells

  • Authors:
    • Mi Suk Kim
    • Myung Jin Park
    • So Jeong Kim
    • Chang Hun Lee
    • Heon Yoo
    • Sang Hoon Shin
    • Eun Sook Song
    • Seung Hoon Lee

  • View Affiliations / Copyright

    Affiliations: Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea
  • Pages: 839-846
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/ijo.27.3.839
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Abstract

Emodin, an inhibitor of protein tyrosine kinase, possesses antiviral, immunosuppressive, anti-inflammatory and anticancer effects. In the present study, we investigated the effect of emodin on the hyaluronic acid (HA)-induced invasion of human glioma cells. Emodin significantly inhibited the HA-induced invasion through a Matrigel coated chamber, secretion of matrix metalloproteinase (MMP)-2, and HA-induced secretion of MMP-9 in glioma cells. To investigate the possible mechanisms involved in these events, we performed Western blot analysis using phospho-specific antibodies, and found that emodin inhibited phosphorylation of focal adhesion kinase (FAK), extracellular regulated protein kinase (ERK) 1/2 and Akt/PKB; emodin also suppressed the transcriptional activity of two transcription factors, activator protein-1 (AP-1) and nuclear factor-κB (NF-κB), in glioma cells. In addition, oral administration of emodin suppressed in vivo MMP secretion by glioma tumors in nude mice. Taken together, our results indicate that emodin can effectively inhibit HA-induced MMP secretion and invasion of glioma through inhibition of FAK, ERK1/2 and Akt/PKB activation and partial inhibition of AP-1 and NF-κB transcriptional activities. Consequently, these results provide important insights into emodin as an anti-invasive agent for the therapy of human glioma.

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Copy and paste a formatted citation
Spandidos Publications style
Kim MS, Park MJ, Kim SJ, Lee CH, Yoo H, Shin SH, Song ES and Lee SH: Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells. Int J Oncol 27: 839-846, 2005.
APA
Kim, M.S., Park, M.J., Kim, S.J., Lee, C.H., Yoo, H., Shin, S.H. ... Lee, S.H. (2005). Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells. International Journal of Oncology, 27, 839-846. https://doi.org/10.3892/ijo.27.3.839
MLA
Kim, M. S., Park, M. J., Kim, S. J., Lee, C. H., Yoo, H., Shin, S. H., Song, E. S., Lee, S. H."Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells". International Journal of Oncology 27.3 (2005): 839-846.
Chicago
Kim, M. S., Park, M. J., Kim, S. J., Lee, C. H., Yoo, H., Shin, S. H., Song, E. S., Lee, S. H."Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells". International Journal of Oncology 27, no. 3 (2005): 839-846. https://doi.org/10.3892/ijo.27.3.839
Copy and paste a formatted citation
x
Spandidos Publications style
Kim MS, Park MJ, Kim SJ, Lee CH, Yoo H, Shin SH, Song ES and Lee SH: Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells. Int J Oncol 27: 839-846, 2005.
APA
Kim, M.S., Park, M.J., Kim, S.J., Lee, C.H., Yoo, H., Shin, S.H. ... Lee, S.H. (2005). Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells. International Journal of Oncology, 27, 839-846. https://doi.org/10.3892/ijo.27.3.839
MLA
Kim, M. S., Park, M. J., Kim, S. J., Lee, C. H., Yoo, H., Shin, S. H., Song, E. S., Lee, S. H."Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells". International Journal of Oncology 27.3 (2005): 839-846.
Chicago
Kim, M. S., Park, M. J., Kim, S. J., Lee, C. H., Yoo, H., Shin, S. H., Song, E. S., Lee, S. H."Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells". International Journal of Oncology 27, no. 3 (2005): 839-846. https://doi.org/10.3892/ijo.27.3.839
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