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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July 2012 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 6 Issue 1

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Review

RNA interference therapeutics for cancer: Challenges and opportunities (Review)

  • Authors:
    • Roop Singh Bora
    • Dikshi Gupta
    • Trilochan Kanwaljit Singh Mukkur
    • Kulvinder Singh Saini

  • View Affiliations / Copyright

    Affiliations: Department of Biotechnology, Ranbaxy Laboratories Limited, Gurgaon-122 015, Haryana, India, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Western Australian Biomedical Research Institute, Curtin University, Bentley Campus, Perth, Western Australia 6102, Australia
  • Pages: 9-15
    |
    Published online on: April 18, 2012
       https://doi.org/10.3892/mmr.2012.871
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Abstract

RNA interference (RNAi) is a sequence-specific, post-transcriptional gene silencing mechanism in animals and plants, which is mediated by double-stranded RNA (dsRNA). There has recently been an increasing interest in harnessing the gene silencing activity of dsRNA to develop novel drugs for the treatment of various diseases, such as cancer, neurological disorders, age-related macular degeneration and viral infections. Small interfering RNA (siRNA)-based drugs have distinct advantages over conventional small molecule or protein-based drugs, including high specificity, higher potency and reduced toxicity. However, there are several technical obstacles to overcome before siRNA-based drugs reach the clinic. Delivery of siRNA to the target tissues and stability in the serum remain a major challenge and are the main focus of current research and development efforts. This review focused primarily on the progress made in developing RNAi as therapeutics for cancer and the challenges associated with its clinical development. Use of ligands recognizing cell-specific receptors to achieve tumor-specific delivery of siRNA, methods for enhanced siRNA delivery, improving the bioavailability and pharmacokinetic properties of siRNA and reducing the off-target effects and non-specific gene silencing are discussed in the light of current evidence.

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Copy and paste a formatted citation
Spandidos Publications style
Bora RS, Gupta D, Mukkur TS and Saini KS: RNA interference therapeutics for cancer: Challenges and opportunities (Review). Mol Med Rep 6: 9-15, 2012.
APA
Bora, R.S., Gupta, D., Mukkur, T.S., & Saini, K.S. (2012). RNA interference therapeutics for cancer: Challenges and opportunities (Review). Molecular Medicine Reports, 6, 9-15. https://doi.org/10.3892/mmr.2012.871
MLA
Bora, R. S., Gupta, D., Mukkur, T. S., Saini, K. S."RNA interference therapeutics for cancer: Challenges and opportunities (Review)". Molecular Medicine Reports 6.1 (2012): 9-15.
Chicago
Bora, R. S., Gupta, D., Mukkur, T. S., Saini, K. S."RNA interference therapeutics for cancer: Challenges and opportunities (Review)". Molecular Medicine Reports 6, no. 1 (2012): 9-15. https://doi.org/10.3892/mmr.2012.871
Copy and paste a formatted citation
x
Spandidos Publications style
Bora RS, Gupta D, Mukkur TS and Saini KS: RNA interference therapeutics for cancer: Challenges and opportunities (Review). Mol Med Rep 6: 9-15, 2012.
APA
Bora, R.S., Gupta, D., Mukkur, T.S., & Saini, K.S. (2012). RNA interference therapeutics for cancer: Challenges and opportunities (Review). Molecular Medicine Reports, 6, 9-15. https://doi.org/10.3892/mmr.2012.871
MLA
Bora, R. S., Gupta, D., Mukkur, T. S., Saini, K. S."RNA interference therapeutics for cancer: Challenges and opportunities (Review)". Molecular Medicine Reports 6.1 (2012): 9-15.
Chicago
Bora, R. S., Gupta, D., Mukkur, T. S., Saini, K. S."RNA interference therapeutics for cancer: Challenges and opportunities (Review)". Molecular Medicine Reports 6, no. 1 (2012): 9-15. https://doi.org/10.3892/mmr.2012.871
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