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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 1994 Volume 1 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1994 Volume 1 Issue 2

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Review

THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW)

  • Authors:
    • HW STURZBECHER
    • W DEPPERT

  • View Affiliations / Copyright

    Affiliations: UNIV HAMBURG,HEINRICH PETTE INST EXPTL VIROL & IMMUNOL,D-20251 HAMBURG,GERMANY.
  • Pages: 301-307
    |
    Published online on: March 1, 1994
       https://doi.org/10.3892/or.1.2.301
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Abstract

Point mutations and/or rearrangements in the tumor suppressor gene p53 are the most common genetic alterations in human cancers. Recent observations indicate that the sum and substance of p53 protein function is the prevention of tumor formation by preservation of genetic stability. This review summarizes and critically discusses various biochemical activities of p53 in relation to the known structural properties of this molecule. It will become apparent that several of the well-accepted biochemical activities of p53 such as p53 oligomerization, p53-protein interactions, and its association with nucleic acids are difficult to reconcile with the known structural features of the p53 polypeptide. More knowledge about the structure-function relationship is thus a critical issue for understanding the biological function of p53 at the molecular level.

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Copy and paste a formatted citation
Spandidos Publications style
STURZBECHER H and DEPPERT W: THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW). Oncol Rep 1: 301-307, 1994.
APA
STURZBECHER, H., & DEPPERT, W. (1994). THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW). Oncology Reports, 1, 301-307. https://doi.org/10.3892/or.1.2.301
MLA
STURZBECHER, H., DEPPERT, W."THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW)". Oncology Reports 1.2 (1994): 301-307.
Chicago
STURZBECHER, H., DEPPERT, W."THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW)". Oncology Reports 1, no. 2 (1994): 301-307. https://doi.org/10.3892/or.1.2.301
Copy and paste a formatted citation
x
Spandidos Publications style
STURZBECHER H and DEPPERT W: THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW). Oncol Rep 1: 301-307, 1994.
APA
STURZBECHER, H., & DEPPERT, W. (1994). THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW). Oncology Reports, 1, 301-307. https://doi.org/10.3892/or.1.2.301
MLA
STURZBECHER, H., DEPPERT, W."THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW)". Oncology Reports 1.2 (1994): 301-307.
Chicago
STURZBECHER, H., DEPPERT, W."THE TUMOR-SUPPRESSOR PROTEIN P53 - RELATIONSHIP OF STRUCTURE TO FUNCTION (REVIEW)". Oncology Reports 1, no. 2 (1994): 301-307. https://doi.org/10.3892/or.1.2.301
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